SYG2_YEAST - dbPTM
SYG2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYG2_YEAST
UniProt AC Q06817
Protein Name Glycine--tRNA ligase 2
Gene Name GRS2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 618
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs (By similarity)..
Protein Sequence MPLMSNSERDKLESTLRRRFFYTPSFEIYGGVSGLFDLGPPGCQLQNNLIRLWREHFIMEENMLQVDGPMLTPYDVLKTSGHVDKFTDWMCRNPKTGEYYRADHLIEQTLKKRLLDKDVNPQDMKNMEKILTTIDGFSGPELNLVMQEYNINDPVTNDVLDALTSFNLMFETKIGASGQLKAFLRPETAQGQFLNFNKLLEINQGKIPFASASIGKSFRNEISPRSGLLRVREFLMAEIEHFVDPLNKSHAKFNEVLNEEIPLLSRRLQESGEVQLPVKMTIGEAVNSGMVENETLGYFMARVHQFLLNIGINKDKFRFRQHLKNEMAHYATDCWDGEILTSYGWIECVGCADRAAFDLTVHSKKTGRSLTVKQKLDTPKERTEWVVEVNKKFFGSKFKQKAKLIESVLSKFSQDELIRRHEELEKNGEFTCQVNGQIVKLDSSLVTIKMKTTLQHIREYIPNVIEPSFGLGRIIYCIFDHCFQVRVDSESRGFFSFPLQIAPIKVFVTTISNNDGFPAILKRISQALRKREIYFKIDDSNTSIGKKYARNDELGTPFGITIDFETIKDQTVTLRERNSMRQVRGTITDVISTIDKMLHNPDESDWDKSTFGLSPVKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
330PhosphorylationLKNEMAHYATDCWDG
HHHHHHHHHCCCCCC		11.1419779198
332PhosphorylationNEMAHYATDCWDGEI
HHHHHHHCCCCCCCE		25.2319779198
373AcetylationTGRSLTVKQKLDTPK
CCCCEEEEEECCCCH		36.1625381059
588PhosphorylationRQVRGTITDVISTID
HHHHHHHHHHHHHHH		24.8527017623
592PhosphorylationGTITDVISTIDKMLH
HHHHHHHHHHHHHHC		21.1128889911
593PhosphorylationTITDVISTIDKMLHN
HHHHHHHHHHHHHCC		23.2828889911
609PhosphorylationDESDWDKSTFGLSPV
CHHHCCCCCCCCCCC		26.8822369663
610PhosphorylationESDWDKSTFGLSPVK
HHHCCCCCCCCCCCC		27.7122369663
614PhosphorylationDKSTFGLSPVKI---
CCCCCCCCCCCC---		28.2022369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYG2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYG2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYG2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PFD5_YEASTGIM5genetic
19061648
DGAT2_YEASTDGA1genetic
21623372
THDH_YEASTILV1genetic
21623372
AK_YEASTHOM3genetic
21623372
URA7_YEASTURA7genetic
21623372
DHOM_YEASTHOM6genetic
21623372
GPT2_YEASTGPT2genetic
21623372
QCR7_YEASTQCR7genetic
21623372
UGPA2_YEASTYHL012Wgenetic
21623372
TNA1_YEASTTNA1genetic
21623372
KPR5_YEASTPRS5genetic
21623372
NDI1_YEASTNDI1genetic
21623372
TRX3_YEASTTRX3genetic
21623372
PGLR_YEASTPGU1genetic
21623372
CATA_YEASTCTA1genetic
21623372
COX9_YEASTCOX9genetic
21623372
PUR6_YEASTADE2genetic
21623372
DCE_YEASTGAD1genetic
21623372
ODO2_YEASTKGD2genetic
21623372
IPT1_YEASTIPT1genetic
21623372
ASPG1_YEASTASP1genetic
21623372
YPR1_YEASTYPR1genetic
21623372
MDHM_YEASTMDH1genetic
21623372
ARO1_YEASTARO1genetic
21623372
COQ3_YEASTCOQ3genetic
21623372
JLP1_YEASTJLP1genetic
21623372
CSG2_YEASTCSG2genetic
21623372
YPC1_YEASTYPC1genetic
21623372
SHE1_YEASTSHE1genetic
27708008
SWC5_YEASTSWC5genetic
27708008
MRM2_YEASTMRM2genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
EOS1_YEASTEOS1genetic
27708008
INO4_YEASTINO4genetic
27708008
TEL2_YEASTTEL2genetic
27708008
ESS1_YEASTESS1genetic
27708008
RIM1_YEASTRIM1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
COX23_YEASTCOX23genetic
27708008
CSF1_YEASTCSF1genetic
27708008
ACE2_YEASTACE2genetic
27708008
SWI6_YEASTSWI6genetic
27708008
RL37A_YEASTRPL37Agenetic
27708008
SWS2_YEASTSWS2genetic
27708008
LIPA_YEASTLIP5genetic
27708008
BEM4_YEASTBEM4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYG2_YEAST

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Related Literatures of Post-Translational Modification

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