| UniProt ID | ARO1_YEAST | |
|---|---|---|
| UniProt AC | P08566 | |
| Protein Name | Pentafunctional AROM polypeptide {ECO:0000255|HAMAP-Rule:MF_03143} | |
| Gene Name | ARO1 {ECO:0000255|HAMAP-Rule:MF_03143} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1588 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.. | |
| Protein Sequence | MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTSSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVANPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAEAEFQALRRSFSKYIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTMKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKVIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKGPFKAIFDAVTKE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Ubiquitination | --MVQLAKVPILGND --CCCCEECCCCCCE | 58.07 | 17644757 | |
| 31 | Ubiquitination | HLVETIIKHCPSSTY HHHHHHHHHCCCCCE | 34.99 | 17644757 | |
| 48 | Ubiquitination | CNDTNLSKVPYYQQL ECCCCCCCCCCCCHH | 50.85 | 17644757 | |
| 60 | Ubiquitination | QQLVLEFKASLPEGS CHHHHHHHHCCCCCC | 27.91 | 17644757 | |
| 75 | Acetylation | RLLTYVVKPGETSKS EEEEEEECCCCCCCC | 36.94 | 24489116 | |
| 75 | Ubiquitination | RLLTYVVKPGETSKS EEEEEEECCCCCCCC | 36.94 | 23749301 | |
| 81 | Ubiquitination | VKPGETSKSRETKAQ ECCCCCCCCHHHHHH | 62.04 | 17644757 | |
| 148 | Phosphorylation | DSSIGGKTAIDTPLG CCCCCCCCCCCCCCC | 31.92 | 19795423 | |
| 152 | Phosphorylation | GGKTAIDTPLGKNFI CCCCCCCCCCCCCCC | 17.82 | 27214570 | |
| 180 | Ubiquitination | KWLETLAKREFINGM HHHHHHHHHHHHHHH | 56.42 | 23749301 | |
| 192 | Ubiquitination | NGMAEVIKTACIWNA HHHHHHHHHHHCCCH | 34.93 | 17644757 | |
| 207 | Phosphorylation | DEFTRLESNASLFLN HHCHHHHCCHHHEEE | 42.14 | 24909858 | |
| 210 | Phosphorylation | TRLESNASLFLNVVN HHHHCCHHHEEEECC | 24.73 | 24909858 | |
| 258 | 2-Hydroxyisobutyrylation | VLESIKVKAEVVSSD HHHHCEEEEEECCCC | 33.55 | - | |
| 258 | Ubiquitination | VLESIKVKAEVVSSD HHHHCEEEEEECCCC | 33.55 | 23749301 | |
| 305 | Ubiquitination | CVSIGMVKEAELSRY ECEECEECHHHHHHH | 42.17 | 23749301 | |
| 326 | Acetylation | TQVARLSKILVAYGL HHHHHHHHHHHHCCC | 44.65 | 24489116 | |
| 326 | Ubiquitination | TQVARLSKILVAYGL HHHHHHHHHHHHCCC | 44.65 | 17644757 | |
| 340 | Acetylation | LPVSPDEKWFKELTL CCCCCCHHHHHHHHC | 66.37 | 24489116 | |
| 340 | Ubiquitination | LPVSPDEKWFKELTL CCCCCCHHHHHHHHC | 66.37 | 17644757 | |
| 343 | Acetylation | SPDEKWFKELTLHKK CCCHHHHHHHHCCCC | 51.18 | 24489116 | |
| 343 | Ubiquitination | SPDEKWFKELTLHKK CCCHHHHHHHHCCCC | 51.18 | 17644757 | |
| 358 | Acetylation | TPLDILLKKMSIDKK CHHHHHHHHHCCCCC | 42.88 | 24489116 | |
| 381 | Ubiquitination | VILESIGKCYGDSAQ EEEEECHHHHCCCCC | 23.71 | 17644757 | |
| 425 | Ubiquitination | VVIPPGSKSISNRAL EEECCCCCCCCHHHH | 58.69 | 23749301 | |
| 428 | Phosphorylation | PPGSKSISNRALILA CCCCCCCCHHHHHHH | 27.62 | 21440633 | |
| 443 | Ubiquitination | ALGEGQCKIKNLLHS HHCCCCCEEECCCCC | 49.15 | 17644757 | |
| 454 | Acetylation | LLHSDDTKHMLTAVH CCCCCCHHHHHHHHH | 33.73 | 24489116 | |
| 454 | Ubiquitination | LLHSDDTKHMLTAVH CCCCCCHHHHHHHHH | 33.73 | 24961812 | |
| 464 | Ubiquitination | LTAVHELKGATISWE HHHHHHHCCCEEEEE | 43.44 | 17644757 | |
| 501 | Phosphorylation | LYLGNAGTASRFLTS EECCCHHHHHHHHHH | 21.03 | 27214570 | |
| 507 | Phosphorylation | GTASRFLTSLAALVN HHHHHHHHHHHHHHC | 20.98 | 28747907 | |
| 508 | Phosphorylation | TASRFLTSLAALVNS HHHHHHHHHHHHHCC | 20.39 | 28747907 | |
| 515 | Phosphorylation | SLAALVNSTSSQKYI HHHHHHCCCCCCCEE | 23.37 | 28747907 | |
| 520 | Ubiquitination | VNSTSSQKYIVLTGN HCCCCCCCEEEEECC | 38.60 | 17644757 | |
| 541 | Phosphorylation | PIAPLVDSLRANGTK CCHHHHHHHHHCCCE | 16.57 | 28747907 | |
| 547 | Phosphorylation | DSLRANGTKIEYLNN HHHHHCCCEEEEECC | 28.76 | 28747907 | |
| 548 | Acetylation | SLRANGTKIEYLNNE HHHHCCCEEEEECCC | 34.63 | 24489116 | |
| 610 | Acetylation | VGGKPISKLYVDMTI ECCEECHHHHHHHHH | 44.55 | 25381059 | |
| 612 | Phosphorylation | GKPISKLYVDMTIKM CEECHHHHHHHHHHH | 9.72 | 19823750 | |
| 616 | Phosphorylation | SKLYVDMTIKMMEKF HHHHHHHHHHHHHHH | 17.00 | 19823750 | |
| 618 | Acetylation | LYVDMTIKMMEKFGI HHHHHHHHHHHHHCC | 24.03 | 25381059 | |
| 695 | Ubiquitination | RFARDVLKPMGCKIT HHHHHHHHHCCCEEE | 32.57 | 23749301 | |
| 700 | Ubiquitination | VLKPMGCKITQTATS HHHHCCCEEEEEECE | 42.96 | 17644757 | |
| 719 | Acetylation | GPPVGTLKPLKHVDM CCCCCCCCCCCCCCC | 48.41 | 24489116 | |
| 719 | Ubiquitination | GPPVGTLKPLKHVDM CCCCCCCCCCCCCCC | 48.41 | 17644757 | |
| 722 | Ubiquitination | VGTLKPLKHVDMEPM CCCCCCCCCCCCCCC | 50.54 | 17644757 | |
| 779 | Ubiquitination | AMATELAKFGVKTTE HHHHHHHHHCCCCCC | 56.10 | 23749301 | |
| 783 | Ubiquitination | ELAKFGVKTTELPDG HHHHHCCCCCCCCCC | 50.54 | 17644757 | |
| 800 | Acetylation | VHGLNSIKDLKVPSD EECCCCCCCCCCCCC | 57.75 | 24489116 | |
| 800 | Ubiquitination | VHGLNSIKDLKVPSD EECCCCCCCCCCCCC | 57.75 | 17644757 | |
| 803 | Ubiquitination | LNSIKDLKVPSDSSG CCCCCCCCCCCCCCC | 63.33 | 23749301 | |
| 856 | Acetylation | LERHCTGKTWPGWWD HHHHCCCCCCCCHHH | 29.30 | 24489116 | |
| 856 | Ubiquitination | LERHCTGKTWPGWWD HHHHCCCCCCCCHHH | 29.30 | 17644757 | |
| 872 | Ubiquitination | LHSELGAKLDGAEPL HHHHHCCCCCCCCCC | 45.36 | 17644757 | |
| 906 | Acetylation | AGKTTISKWCASALG CCCCHHHHHHHHHHC | 42.30 | 24489116 | |
| 915 | Ubiquitination | CASALGYKLVDLDEL HHHHHCCEECCHHHH | 39.99 | 17644757 | |
| 933 | Ubiquitination | QHNNQSVKQFVVENG HHCCCCHHHHHHHCC | 43.18 | 23749301 | |
| 943 | Acetylation | VVENGWEKFREEETR HHHCCHHHHHHHHHH | 43.12 | 24489116 | |
| 959 | Phosphorylation | FKEVIQNYGDDGYVF HHHHHHHHCCCCEEE | 12.93 | 22369663 | |
| 964 | Phosphorylation | QNYGDDGYVFSTGGG HHHCCCCEEEECCCC | 12.81 | 22369663 | |
| 967 | Phosphorylation | GDDGYVFSTGGGIVE CCCCEEEECCCCHHC | 18.99 | 22369663 | |
| 968 | Phosphorylation | DDGYVFSTGGGIVES CCCEEEECCCCHHCC | 28.51 | 22369663 | |
| 975 | Phosphorylation | TGGGIVESAESRKAL CCCCHHCCHHHHHHH | 26.83 | 22369663 | |
| 978 | Phosphorylation | GIVESAESRKALKDF CHHCCHHHHHHHHHH | 38.51 | 22369663 | |
| 983 | Ubiquitination | AESRKALKDFASSGG HHHHHHHHHHHHCCC | 56.51 | 17644757 | |
| 1011 | Phosphorylation | VFLQSDPSRPAYVEE EEEECCCCCCHHHHH | 56.75 | 27017623 | |
| 1031 | Ubiquitination | NRREGWYKECSNFSF HHCCCCHHHCCCCCE | 45.82 | 17644757 | |
| 1058 | Acetylation | ALRRSFSKYIATITG HHHHHHHHHCHHHHC | 38.37 | 24489116 | |
| 1058 | Ubiquitination | ALRRSFSKYIATITG HHHHHHHHHCHHHHC | 38.37 | 23749301 | |
| 1120 | Acetylation | YSADFVSKQLSILRK CCHHHHHHHHHHHHH | 50.37 | 24489116 | |
| 1120 | Ubiquitination | YSADFVSKQLSILRK CCHHHHHHHHHHHHH | 50.37 | 17644757 | |
| 1127 | Ubiquitination | KQLSILRKATDSIPI HHHHHHHHHCCCCCE | 52.79 | 23749301 | |
| 1140 | Phosphorylation | PIIFTVRTMKQGGNF CEEEEEECCCCCCCC | 25.12 | 28889911 | |
| 1153 | Acetylation | NFPDEEFKTLRELYD CCCHHHHHHHHHHHH | 50.35 | 24489116 | |
| 1154 | Phosphorylation | FPDEEFKTLRELYDI CCHHHHHHHHHHHHH | 36.05 | 28889911 | |
| 1249 | Ubiquitination | EHFRDTHKNKPLIAV HHHHCCCCCCCEEEE | 69.62 | 17644757 | |
| 1251 | Ubiquitination | FRDTHKNKPLIAVNM HHCCCCCCCEEEEEC | 46.10 | 17644757 | |
| 1261 | Ubiquitination | IAVNMTSKGSISRVL EEEECCCCCHHHHHH | 47.73 | 17644757 | |
| 1307 | Acetylation | SMGGIEPKELFVVGK HCCCCCCCEEEEECC | 55.01 | 24489116 | |
| 1307 | Ubiquitination | SMGGIEPKELFVVGK HCCCCCCCEEEEECC | 55.01 | 17644757 | |
| 1314 | Acetylation | KELFVVGKPIGHSRS CEEEEECCCCCCCCC | 23.11 | 24489116 | |
| 1314 | Ubiquitination | KELFVVGKPIGHSRS CEEEEECCCCCCCCC | 23.11 | 17644757 | |
| 1321 | Phosphorylation | KPIGHSRSPILHNTG CCCCCCCCCCCCCCC | 21.21 | 22369663 | |
| 1327 | Phosphorylation | RSPILHNTGYEILGL CCCCCCCCCCCCCCC | 30.32 | 22369663 | |
| 1329 | Phosphorylation | PILHNTGYEILGLPH CCCCCCCCCCCCCCC | 9.58 | 22369663 | |
| 1337 | Acetylation | EILGLPHKFDKFETE CCCCCCCCCCCCCCH | 54.00 | 24489116 | |
| 1337 | Ubiquitination | EILGLPHKFDKFETE CCCCCCCCCCCCCCH | 54.00 | 17644757 | |
| 1340 | Acetylation | GLPHKFDKFETESAQ CCCCCCCCCCCHHHH | 48.51 | 24489116 | |
| 1340 | Ubiquitination | GLPHKFDKFETESAQ CCCCCCCCCCCHHHH | 48.51 | 23749301 | |
| 1345 | Phosphorylation | FDKFETESAQLVKEK CCCCCCHHHHHHHHH | 28.83 | 28889911 | |
| 1350 | Ubiquitination | TESAQLVKEKLLDGN CHHHHHHHHHHHCCC | 58.69 | 23749301 | |
| 1385 | Ubiquitination | DELTDAAKVIGAVNT HHHHHHHHHHHHCCE | 35.78 | 17644757 | |
| 1399 | Ubiquitination | TVIPLGNKKFKGDNT EEEECCCCCCCCCCC | 58.76 | 22817900 | |
| 1400 | Ubiquitination | VIPLGNKKFKGDNTD EEECCCCCCCCCCCC | 57.20 | 22817900 | |
| 1402 | Acetylation | PLGNKKFKGDNTDWL ECCCCCCCCCCCCCC | 74.39 | 24489116 | |
| 1402 | Ubiquitination | PLGNKKFKGDNTDWL ECCCCCCCCCCCCCC | 74.39 | 23749301 | |
| 1451 | Ubiquitination | ALHSLGCKKIFIINR HHHHCCCCEEEEEEC | 47.29 | 17644757 | |
| 1452 | Ubiquitination | LHSLGCKKIFIINRT HHHCCCCEEEEEECC | 47.10 | 17644757 | |
| 1459 | Phosphorylation | KIFIINRTTSKLKPL EEEEEECCCCCCHHH | 30.82 | 21126336 | |
| 1462 | Acetylation | IINRTTSKLKPLIES EEECCCCCCHHHHHH | 59.44 | 24489116 | |
| 1462 | Ubiquitination | IINRTTSKLKPLIES EEECCCCCCHHHHHH | 59.44 | 17644757 | |
| 1464 | Ubiquitination | NRTTSKLKPLIESLP ECCCCCCHHHHHHCC | 41.33 | 17644757 | |
| 1469 | Phosphorylation | KLKPLIESLPSEFNI CCHHHHHHCCCCCCE | 38.29 | 22369663 | |
| 1472 | Phosphorylation | PLIESLPSEFNIIGI HHHHHCCCCCCEEEE | 61.18 | 22369663 | |
| 1483 | Ubiquitination | IIGIESTKSIEEIKE EEEEECCCCHHHHHH | 59.73 | 17644757 | |
| 1497 | Phosphorylation | EHVGVAVSCVPADKP HHHCEEEEEEECCCC | 10.31 | 29688323 | |
| 1511 | Phosphorylation | PLDDELLSKLERFLV CCCHHHHHHHHHHHH | 48.06 | 29688323 | |
| 1519 | Ubiquitination | KLERFLVKGAHAAFV HHHHHHHHHHHHHHH | 53.15 | 17644757 | |
| 1535 | Acetylation | TLLEAAYKPSVTPVM HHHHHHHCCCCCCCE | 26.53 | 24489116 | |
| 1535 | Ubiquitination | TLLEAAYKPSVTPVM HHHHHHHCCCCCCCE | 26.53 | 17644757 | |
| 1548 | Ubiquitination | VMTISQDKYQWHVVP CEEECCCCCEEEECC | 31.53 | 17644757 | |
| 1570 | Ubiquitination | QGVAQFEKWTGFKGP CCCCCCCCHHCCCCC | 51.88 | 17644757 | |
| 1575 | Acetylation | FEKWTGFKGPFKAIF CCCHHCCCCCHHHHH | 68.00 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ARO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ARO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ARO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
