GLT1_YEAST - dbPTM
GLT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLT1_YEAST
UniProt AC Q12680
Protein Name Glutamate synthase [NADH]
Gene Name GLT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 2145
Subcellular Localization
Protein Description Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate..
Protein Sequence MPVLKSDNFDPLEEAYEGGTIQNYNDEHHLHKSWANVIPDKRGLYDPDYEHDACGVGFVANKHGEQSHKIVTDARYLLVNMTHRGAVSSDGNGDGAGILLGIPHEFMKREFKLDLDLDIPEMGKYAVGNVFFKKNEKNNKKNLIKCQKIFEDLAASFNLSVLGWRNVPVDSTILGDVALSREPTILQPLLVPLYDEKQPEFNETKFRTQLYLLRKEASLQIGLENWFYVCSLNNTTIVYKGQLTPAQVYNYYPDLTNAHFKSHMALVHSRFSTNTFPSWDRAQPLRWLAHNGEINTLRGNKNWMRSREGVMNSATFKDELDKLYPIIEEGGSDSAALDNVLELLTINGTLSLPEAVMMMVPEAYHKDMDSDLKAWYDWAACLMEPWDGPALLTFTDGRYCGAILDRNGLRPCRYYITSDDRVICASEVGVIPIENSLVVQKGKLKPGDLFLVDTQLGEMVDTKKLKSQISKRQDFKSWLSKVIKLDDLLSKTANLVPKEFISQDSLSLKVQSDPRLLANGYTFEQVTFLLTPMALTGKEALGSMGNDAPLACLNENPVLLYDYFRQLFAQVTNPPIDPIREANVMSLECYVGPQGNLLEMHSSQCDRLLLKSPILHWNEFQALKNIEAAYPSWSVAEIDITFDKSEGLLGYTDTIDKITKLASEAIDDGKKILIITDRKMGANRVSISSLIAISCIHHHLIRNKQRSQVALILETGEAREIHHFCVLLGYGCDGVYPYLAMETLVRMNREGLLRNVNNDNDTLEEGQILENYKHAIDAGILKVMSKMGISTLASYKGAQIFEALGLDNSIVDLCFTGTSSRIRGVTFEYLAQDAFSLHERGYPSRQTISKSVNLPESGEYHFRDGGYKHVNEPTAIASLQDTVRNKNDVSWQLYVKKEMEAIRDCTLRGLLELDFENSVSIPLEQVEPWTEIARRFASGAMSYGSISMEAHSTLAIAMNRLGAKSNCGEGGEDAERSAVQENGDTMRSAIKQVASARFGVTSYYLSDADEIQIKIAQGAKPGEGGELPAHKVSKDIAKTRHSTPNVGLISPPPHHDIYSIEDLKQLIYDLKCANPRAGISVKLVSEVGVGIVASGVAKAKADHILVSGHDGGTGAARWTSVKYAGLPWELGLAETHQTLVLNDLRRNVVVQTDGQLRTGFDIAVAVLLGAESFTLATVPLIAMGCVMLRRCHLNSCAVGIATQDPYLRSKFKGQPEHVINFFYYLIQDLRQIMAKLGFRTIDEMVGHSEKLKKRDDVNAKAINIDLSPILTPAHVIRPGVPTKFTKKQDHKLHTRLDNKLIDEAEVTLDRGLPVNIDASIINTDRALGSTLSYRVSKKFGEDGLPKDTVVVNIEGSAGQSFGAFLASGITFILNGDANDYVGKGLSGGIIVIKPPKDSKFKSDENVIVGNTCFYGATSGTAFISGSAGERFGVRNSGATIVVERIKGNNAFEYMTGGRAIVLSQMESLNAFSGATGGIAYCLTSDYDDFVGKINKDTVELESLCDPVEIAFVKNLIQEHWNYTQSDLAARILGNFNHYLKDFVKVIPTDYKKVLLKEKAEAAKAKAKATSEYLKKFRSNQEVDDEVNTLLIANQKAKEQEKKKSITISNKATLKEPKVVDLEDAVPDSKQLEKNSERIEKTRGFMIHKRRHETHRDPRTRVNDWKEFTNPITKKDAKYQTARCMDCGTPFCLSDTGCPLSNIIPKFNELLFKNQWKLALDKLLETNNFPEFTGRVCPAPCEGACTLGIIEDPVGIKSVERIIIDNAFKEGWIKPCPPSTRTGFTVGVIGSGPAGLACADMLNRAGHTVTVYERSDRCGGLLMYGIPNMKLDKAIVQRRIDLLSAEGIDFVTNTEIGKTISMDELKNKHNAVVYAIGSTIPRDLPIKGRELKNIDFAMQLLESNTKALLNKDLEIIREKIQGKKVIVVGGGDTGNDCLGTSVRHGAASVLNFELLPEPPVERAKDNPWPQWPRVMRVDYGHAEVKEHYGRDPREYCILSKEFIGNDEGEVTAIRTVRVEWKKSQSGVWQMVEIPNSEEIFEADIILLSMGFVGPELINGNDNEVKKTRRGTIATLDDSSYSIDGGKTFACGDCRRGQSLIVWAIQEGRKCAASVDKFLMDGTTYLPSNGGIVQRDYKLLKELASQV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
108AcetylationGIPHEFMKREFKLDL
ECCHHHHCCHHCCCC		54.8424489116
124UbiquitinationLDIPEMGKYAVGNVF
CCCCHHCCEEHHHEE		28.8217644757
133AcetylationAVGNVFFKKNEKNNK
EHHHEEEECCCCCCC		43.1324489116
133UbiquitinationAVGNVFFKKNEKNNK
EHHHEEEECCCCCCC		43.1317644757
134UbiquitinationVGNVFFKKNEKNNKK
HHHEEEECCCCCCCC		66.2417644757
148UbiquitinationKNLIKCQKIFEDLAA
CCEEHHHHHHHHHHH		59.8517644757
197AcetylationLVPLYDEKQPEFNET
EEECCCCCCCCCCCC		69.1524489116
197UbiquitinationLVPLYDEKQPEFNET
EEECCCCCCCCCCCC		69.1523749301
240UbiquitinationNNTTIVYKGQLTPAQ
CCCEEEECCEECHHH		29.3217644757
261AcetylationDLTNAHFKSHMALVH
CCCHHHHHHCHHHHH		29.5924489116
261UbiquitinationDLTNAHFKSHMALVH
CCCHHHHHHCHHHHH		29.5917644757
366UbiquitinationMVPEAYHKDMDSDLK
HCCHHHHCCCCCHHH		41.9117644757
373UbiquitinationKDMDSDLKAWYDWAA
CCCCCHHHHHHHHHH		41.6917644757
476AcetylationISKRQDFKSWLSKVI
HHHHHCHHHHHHHHH		49.3524489116
484AcetylationSWLSKVIKLDDLLSK
HHHHHHHCHHHHHHH		49.1824489116
491AcetylationKLDDLLSKTANLVPK
CHHHHHHHHCCCCCH		52.1824489116
498AcetylationKTANLVPKEFISQDS
HHCCCCCHHHCCCCC		58.7524489116
611AcetylationQCDRLLLKSPILHWN
HHCHHHHHCCCCCHH		54.9024489116
611UbiquitinationQCDRLLLKSPILHWN
HHCHHHHHCCCCCHH		54.9017644757
612PhosphorylationCDRLLLKSPILHWNE
HCHHHHHCCCCCHHH		19.6922369663
624UbiquitinationWNEFQALKNIEAAYP
HHHHHHHCCHHHHCC		59.9217644757
644UbiquitinationEIDITFDKSEGLLGY
EEEEEEECCCCCCCC		46.3317644757
657UbiquitinationGYTDTIDKITKLASE
CCCHHHHHHHHHHHH		48.7217644757
671UbiquitinationEAIDDGKKILIITDR
HHCCCCCEEEEEECC		48.5517644757
679UbiquitinationILIITDRKMGANRVS
EEEEECCCCCCCCCC		44.4917644757
773UbiquitinationGQILENYKHAIDAGI
CHHHHHHHHHHHHHH		37.8417644757
782UbiquitinationAIDAGILKVMSKMGI
HHHHHHHHHHHHCCC		33.6917644757
796UbiquitinationISTLASYKGAQIFEA
CHHHHHHCHHHHHHH		45.3217644757
850UbiquitinationPSRQTISKSVNLPES
CCCCCCCCCCCCCCC		55.3517644757
857PhosphorylationKSVNLPESGEYHFRD
CCCCCCCCCCEEECC		34.6821440633
868AcetylationHFRDGGYKHVNEPTA
EECCCCCCCCCCCCE		44.3324489116
868UbiquitinationHFRDGGYKHVNEPTA
EECCCCCCCCCCCCE		44.3317644757
886UbiquitinationLQDTVRNKNDVSWQL
CHHHHCCCCCCCEEE		43.9117644757
896UbiquitinationVSWQLYVKKEMEAIR
CCEEEEEHHHHHHHH		29.4717644757
897UbiquitinationSWQLYVKKEMEAIRD
CEEEEEHHHHHHHHC		52.8517644757
938PhosphorylationEIARRFASGAMSYGS
HHHHHHHHCCCCCCC		25.1127017623
942PhosphorylationRFASGAMSYGSISME
HHHHCCCCCCCEEHH		26.3027017623
943PhosphorylationFASGAMSYGSISMEA
HHHCCCCCCCEEHHH		11.2127017623
947PhosphorylationAMSYGSISMEAHSTL
CCCCCCEEHHHHHHH		16.5627017623
964UbiquitinationAMNRLGAKSNCGEGG
HHHHHCCCCCCCCCC		40.1623749301
977PhosphorylationGGEDAERSAVQENGD
CCHHHHHHHHHHCHH		25.0523749301
1014UbiquitinationDADEIQIKIAQGAKP
CHHHEEEEEECCCCC		18.6617644757
1020UbiquitinationIKIAQGAKPGEGGEL
EEEECCCCCCCCCCC		61.4517644757
1031UbiquitinationGGELPAHKVSKDIAK
CCCCCCCCCCHHHHH		50.7617644757
1034UbiquitinationLPAHKVSKDIAKTRH
CCCCCCCHHHHHCCC		57.0217644757
1038UbiquitinationKVSKDIAKTRHSTPN
CCCHHHHHCCCCCCC		46.5617644757
1064UbiquitinationIYSIEDLKQLIYDLK
CCCHHHHHHHHHHCC		56.2117644757
1098UbiquitinationIVASGVAKAKADHIL
CHHHHCHHHCCCEEE		48.2717644757
1100UbiquitinationASGVAKAKADHILVS
HHHCHHHCCCEEEEE		54.3523749301
1107PhosphorylationKADHILVSGHDGGTG
CCCEEEEECCCCCCC		27.2822369663
1113PhosphorylationVSGHDGGTGAARWTS
EECCCCCCCCCCCEE		29.2222369663
1210UbiquitinationQDPYLRSKFKGQPEH
CCHHHHHHCCCCCHH		44.6617644757
1212UbiquitinationPYLRSKFKGQPEHVI
HHHHHHCCCCCHHHH		61.4417644757
1250AcetylationEMVGHSEKLKKRDDV
HHHCCHHHHCCCCCC		69.4924489116
1267PhosphorylationKAINIDLSPILTPAH
CEECCCCCCCCCCHH		13.2222369663
1271PhosphorylationIDLSPILTPAHVIRP
CCCCCCCCCHHHCCC		21.1022369663
1282PhosphorylationVIRPGVPTKFTKKQD
HCCCCCCCCCCCCCC		36.0622369663
1283AcetylationIRPGVPTKFTKKQDH
CCCCCCCCCCCCCCC		44.9924489116
1299AcetylationLHTRLDNKLIDEAEV
HHHHHCCCCCCCEEE		46.6224489116
1436PhosphorylationERFGVRNSGATIVVE
CCCCCCCCCCEEEEE		21.1724909858
1446UbiquitinationTIVVERIKGNNAFEY
EEEEEEECCCCCEEE		62.9024961812
1495UbiquitinationDFVGKINKDTVELES
HHCCCCCCCCEEHHH		59.2417644757
1502PhosphorylationKDTVELESLCDPVEI
CCCEEHHHHCCHHHH		47.0927017623
1513UbiquitinationPVEIAFVKNLIQEHW
HHHHHHHHHHHHHHC		39.3117644757
1540AcetylationGNFNHYLKDFVKVIP
HCCHHHHHHHHHHCC		41.7924489116
1540UbiquitinationGNFNHYLKDFVKVIP
HCCHHHHHHHHHHCC		41.7917644757
1544AcetylationHYLKDFVKVIPTDYK
HHHHHHHHHCCCCHH		34.1524489116
1575UbiquitinationATSEYLKKFRSNQEV
HHHHHHHHHHCCCCC		43.3317644757
1578PhosphorylationEYLKKFRSNQEVDDE
HHHHHHHCCCCCCHH		46.1024909858
1588PhosphorylationEVDDEVNTLLIANQK
CCCHHHHHHHHHCHH		28.2828889911
1595UbiquitinationTLLIANQKAKEQEKK
HHHHHCHHHHHHHHH		62.3217644757
1604PhosphorylationKEQEKKKSITISNKA
HHHHHHHCCEECCCC		33.5721440633
1606PhosphorylationQEKKKSITISNKATL
HHHHHCCEECCCCCC		25.9919823750
1608PhosphorylationKKKSITISNKATLKE
HHHCCEECCCCCCCC		24.5119823750
1617AcetylationKATLKEPKVVDLEDA
CCCCCCCEEECHHHC		56.8524489116
1617UbiquitinationKATLKEPKVVDLEDA
CCCCCCCEEECHHHC		56.8517644757
1628PhosphorylationLEDAVPDSKQLEKNS
HHHCCCCHHHHHHHH		19.0723749301
1629UbiquitinationEDAVPDSKQLEKNSE
HHCCCCHHHHHHHHH		67.3017644757
1665AcetylationRTRVNDWKEFTNPIT
CCCCCCHHHHCCCCC		45.9024489116
1665UbiquitinationRTRVNDWKEFTNPIT
CCCCCCHHHHCCCCC		45.9017644757
1673UbiquitinationEFTNPITKKDAKYQT
HHCCCCCHHHHCCCC		49.7517644757
1674UbiquitinationFTNPITKKDAKYQTA
HCCCCCHHHHCCCCE		55.0217644757
1705UbiquitinationPLSNIIPKFNELLFK
CHHHHHHHHHHHHCC		50.8717644757
1712AcetylationKFNELLFKNQWKLAL
HHHHHHCCCHHHHHH		48.4724489116
1716UbiquitinationLLFKNQWKLALDKLL
HHCCCHHHHHHHHHH		17.7017644757
1721UbiquitinationQWKLALDKLLETNNF
HHHHHHHHHHHHCCC		56.6823749301
1756UbiquitinationIEDPVGIKSVERIII
ECCCCCCCCEEEEEE		42.3917644757
1768AcetylationIIIDNAFKEGWIKPC
EEECCHHHCCCCCCC		53.5624489116
1768UbiquitinationIIIDNAFKEGWIKPC
EEECCHHHCCCCCCC		53.5617644757
1773UbiquitinationAFKEGWIKPCPPSTR
HHHCCCCCCCCCCCC		33.7717644757
1809PhosphorylationNRAGHTVTVYERSDR
HHCCCEEEEEECCCC		20.6519779198
1814PhosphorylationTVTVYERSDRCGGLL
EEEEEECCCCCCCCE		19.9119779198
1858PhosphorylationTNTEIGKTISMDELK
ECCCCCCEECHHHHH		17.0519823750
1860PhosphorylationTEIGKTISMDELKNK
CCCCCEECHHHHHHC		25.9719823750
1865AcetylationTISMDELKNKHNAVV
EECHHHHHHCCCEEE		63.0024489116
1865UbiquitinationTISMDELKNKHNAVV
EECHHHHHHCCCEEE		63.0017644757
1867UbiquitinationSMDELKNKHNAVVYA
CHHHHHHCCCEEEEE		36.3317644757
1891UbiquitinationPIKGRELKNIDFAMQ
CCCCCCCCCHHHHHH		47.2917644757
1905UbiquitinationQLLESNTKALLNKDL
HHHHHCHHHHHCCCH		41.0924961812
1910AcetylationNTKALLNKDLEIIRE
CHHHHHCCCHHHHHH		64.7524489116
1910UbiquitinationNTKALLNKDLEIIRE
CHHHHHCCCHHHHHH		64.7524961812
1922UbiquitinationIREKIQGKKVIVVGG
HHHHHCCCEEEEECC		27.7317644757
1923UbiquitinationREKIQGKKVIVVGGG
HHHHCCCEEEEECCC		43.9823749301
1947PhosphorylationSVRHGAASVLNFELL
HHHCCCCCCCCCEEC		26.9722369663
1963UbiquitinationEPPVERAKDNPWPQW
CCCCHHCCCCCCCCC		65.3517644757
1987PhosphorylationHAEVKEHYGRDPREY
CHHHHHHHCCCHHHE		18.2327017623
1999UbiquitinationREYCILSKEFIGNDE
HHEEEEECEECCCCC		53.8817644757
2070PhosphorylationVKKTRRGTIATLDDS
CCCCCCCCEEECCCC		12.9628889911
2085UbiquitinationSYSIDGGKTFACGDC
CEEECCCCEEECCCC		46.1017644757
2108UbiquitinationWAIQEGRKCAASVDK
EEECCCCCCEEECCC		38.8017644757
2115UbiquitinationKCAASVDKFLMDGTT
CCEEECCCHHCCCCC		37.9423749301
2139UbiquitinationQRDYKLLKELASQV-
HHHHHHHHHHHHCC-		62.2023749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GFA1_YEASTGFA1physical
16429126
IMB4_YEASTKAP123physical
16429126
RS5_YEASTRPS5physical
16429126
RL10_YEASTRPL10physical
16429126
RSSA1_YEASTRPS0Aphysical
16429126
ADH3_YEASTADH3genetic
21623372
ALAM_YEASTALT1genetic
21623372
GPD2_YEASTGPD2genetic
23801122
STL1_YEASTSTL1genetic
23801122
GLT1_YEASTGLT1physical
24771766
ASK10_YEASTASK10genetic
27708008
PTH_YEASTPTH1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
JLP1_YEASTJLP1genetic
27708008
PO152_YEASTPOM152genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
YO378_YEASTAMF1genetic
27708008
GPI10_YEASTGPI10genetic
27708008
SWC4_YEASTSWC4genetic
27708008
TEL2_YEASTTEL2genetic
27708008
MED6_YEASTMED6genetic
27708008
SEC22_YEASTSEC22genetic
27708008
CLP1_YEASTCLP1genetic
27708008
MDM10_YEASTMDM10genetic
27708008
ETR1_YEASTETR1genetic
27708008
NRG2_YEASTNRG2genetic
27708008
RV161_YEASTRVS161genetic
27708008
RIM1_YEASTRIM1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
XRS2_YEASTXRS2genetic
27708008
BCS1_YEASTBCS1genetic
27708008
GMC1_YEASTGMC1genetic
27708008
BEM2_YEASTBEM2genetic
27708008
WWM1_YEASTWWM1genetic
27708008
LEUC_YEASTLEU1genetic
27708008
MMS2_YEASTMMS2genetic
27708008
MUP1_YEASTMUP1genetic
27708008
MED20_YEASTSRB2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
NSG1_YEASTNSG1genetic
27708008
STB5_YEASTSTB5genetic
27708008
FLX1_YEASTFLX1genetic
27708008
YJE9_YEASTYJL049Wgenetic
27708008
BCK1_YEASTBCK1genetic
27708008
RPE_YEASTRPE1genetic
27708008
YAK1_YEASTYAK1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
SFC1_YEASTSFC1genetic
27708008
UTH1_YEASTUTH1genetic
27708008
HMX1_YEASTHMX1genetic
27708008
LIPB_YEASTLIP2genetic
27708008
CDA2_YEASTCDA2genetic
27708008
NMD4_YEASTNMD4genetic
27708008
DUS3_YEASTDUS3genetic
27708008
BUL2_YEASTBUL2genetic
27708008
YMY9_YEASTYMR099Cgenetic
27708008
GAS4_YEASTGAS4genetic
27708008
DIA2_YEASTDIA2genetic
27708008
YVC1_YEASTYVC1genetic
27708008
VPS21_YEASTVPS21genetic
27708008
UBP2_YEASTUBP2genetic
27708008
YOR31_YEASTYOR131Cgenetic
27708008
LIPA_YEASTLIP5genetic
27708008
FRE3_YEASTFRE3genetic
27708008
VTC3_YEASTVTC3genetic
27708008
YP071_YEASTYPL071Cgenetic
27708008
FMP30_YEASTFMP30genetic
27708008
COX10_YEASTCOX10genetic
27708008
DDC1_YEASTDDC1genetic
27708008
PCL8_YEASTPCL8genetic
27708008
GAL4_YEASTGAL4genetic
27708008
PPAL_YEASTLTP1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLT1_YEAST

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Related Literatures of Post-Translational Modification

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