| UniProt ID | IMB4_YEAST | |
|---|---|---|
| UniProt AC | P40069 | |
| Protein Name | Importin subunit beta-4 {ECO:0000305} | |
| Gene Name | KAP123 {ECO:0000303|PubMed:8849456} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1113 | |
| Subcellular Localization | Cytoplasm . Nucleus . Nucleus, nuclear pore complex . | |
| Protein Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Its predominant cargo substrate seems to be ribosomal proteins. [PubMed: 9321403 Required for import of the ribbosomal assembly factor NMD3] | |
| Protein Sequence | MDQQFLSQLEQTLHAITSGVGLKEATKTLQTQFYTQPTTLPALIHILQNGSDDSLKQLAGVEARKLVSKHWNAIDESTRASIKTSLLQTAFSEPKENVRHSNARVIASIGTEELDGNKWPDLVPNLIQTASGEDVQTRQTAIFILFSLLEDFTSSLSGHIDDFLALFSQTINDPSSLEIRSLSAQALNHVSALIEEQETINPVQAQKFAASIPSVVNVLDAVIKADDTMNAKLIFNCLNDFLLLDSQLTGNFIVDLIKLSLQIAVNSEIDEDVRVFALQFIISSLSYRKSKVSQSKLGPEITVAALKVACEEIDVDDELNNEDETGENEENTPSSSAIRLLAFASSELPPSQVASVIVEHIPAMLQSANVFERRAILLAISVAVTGSPDYILSQFDKIIPATINGLKDTEPIVKLAALKCIHQLTTDLQDEVAKFHEEYLPLIIDIIDSAKNIVIYNYATVALDGLLEFIAYDAIAKYLDPLMNKLFYMLESNESSKLRCAVVSAIGSAAFAAGSAFIPYFKTSVHYLEKFIQNCSQIEGMSEDDIELRANTFENISTMARAVRSDAFAEFAEPLVNSAYEAIKTDSARLRESGYAFIANLAKVYGENFAPFLKTILPEIFKTLELDEYQFNFDGDAEDLAAFADSANEEELQNKFTVNTGISYEKEVASAALSELALGTKEHFLPYVEQSLKVLNEQVDESYGLRETALNTIWNVVKSVLLASKVEPESYPKGIPASSYVNADVLAVIQAARETSMGNLSDEFETSMVITVMEDFANMIKQFGAIIIMDNGDSSMLEALCMQVLSVLKGTHTCQTIDIEEDVPRDEELDASETEATLQDVALEVLVSLSQALAGDFAKVFDNFRPVVFGLFQSKSKNKRSSAVGAASELALGMKEQNPFVHEMLEALVIRLTSDKSLEVRGNAAYGVGLLCEYASMDISAVYEPVLKALYELLSAADQKALAAEDDEATREIIDRAYANASGCVARMALKNSALVPLEQTVPALLAHLPLNTGFEEYNPIFELIMKLYQENSPVITNETPRIIEIFSAVFTKENDRIKLEKESTLGREENMERLKQFQTEEMKHKVIELLKYLNTTYNGIVAQNPVLAAVIA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MDQQFLSQLEQTLH -CCHHHHHHHHHHHH | 33.73 | 30377154 | |
| 18 | Phosphorylation | QTLHAITSGVGLKEA HHHHHHHHCCCHHHH | 25.93 | 30377154 | |
| 27 | Ubiquitination | VGLKEATKTLQTQFY CCHHHHHHHHHHHCC | 55.04 | 17644757 | |
| 56 | Ubiquitination | NGSDDSLKQLAGVEA HCCCHHHHHHHHHHH | 47.41 | 17644757 | |
| 65 | Acetylation | LAGVEARKLVSKHWN HHHHHHHHHHHHHHH | 61.36 | 24489116 | |
| 69 | Acetylation | EARKLVSKHWNAIDE HHHHHHHHHHHHCCH | 45.20 | 24489116 | |
| 69 | Ubiquitination | EARKLVSKHWNAIDE HHHHHHHHHHHHCCH | 45.20 | 17644757 | |
| 83 | Ubiquitination | ESTRASIKTSLLQTA HHHHHHHHHHHHHHH | 29.57 | 15699485 | |
| 84 | Phosphorylation | STRASIKTSLLQTAF HHHHHHHHHHHHHHC | 23.96 | 24909858 | |
| 95 | Acetylation | QTAFSEPKENVRHSN HHHCCCCHHHCCCCC | 58.85 | 24489116 | |
| 95 | Ubiquitination | QTAFSEPKENVRHSN HHHCCCCHHHCCCCC | 58.85 | 24961812 | |
| 118 | Ubiquitination | TEELDGNKWPDLVPN CCCCCCCCCCCCCCH | 66.68 | 22106047 | |
| 228 | Phosphorylation | AVIKADDTMNAKLIF HHHHCCCCCCHHHHH | 16.93 | 19795423 | |
| 293 | Phosphorylation | SYRKSKVSQSKLGPE HHCCCCCCHHHCCCH | 32.26 | 28889911 | |
| 296 | Acetylation | KSKVSQSKLGPEITV CCCCCHHHCCCHHHH | 50.23 | 24489116 | |
| 402 | Phosphorylation | FDKIIPATINGLKDT HHHHHHHHHCCCCCC | 15.04 | 28889911 | |
| 407 | Succinylation | PATINGLKDTEPIVK HHHHCCCCCCHHHHH | 65.09 | 23954790 | |
| 407 | Acetylation | PATINGLKDTEPIVK HHHHCCCCCCHHHHH | 65.09 | 24489116 | |
| 478 | Phosphorylation | AYDAIAKYLDPLMNK HHHHHHHHHHHHHHH | 13.81 | 19795423 | |
| 488 | Phosphorylation | PLMNKLFYMLESNES HHHHHHHHHHHCCCC | 15.95 | 19795423 | |
| 492 | Phosphorylation | KLFYMLESNESSKLR HHHHHHHCCCCCHHH | 41.77 | 19795423 | |
| 495 | Phosphorylation | YMLESNESSKLRCAV HHHHCCCCCHHHHHH | 36.70 | 19823750 | |
| 496 | Phosphorylation | MLESNESSKLRCAVV HHHCCCCCHHHHHHH | 29.54 | 19823750 | |
| 497 | Acetylation | LESNESSKLRCAVVS HHCCCCCHHHHHHHH | 49.59 | 24489116 | |
| 584 | Ubiquitination | NSAYEAIKTDSARLR HHHHHHHHCCCHHHH | 54.01 | 17644757 | |
| 603 | Ubiquitination | AFIANLAKVYGENFA HHHHHHHHHHCCCHH | 38.87 | 17644757 | |
| 614 | Ubiquitination | ENFAPFLKTILPEIF CCHHHHHHHHHHHHH | 33.62 | 23749301 | |
| 623 | Phosphorylation | ILPEIFKTLELDEYQ HHHHHHHHCCCCEEE | 18.08 | 19823750 | |
| 629 | Phosphorylation | KTLELDEYQFNFDGD HHCCCCEEEECCCCC | 20.33 | 19823750 | |
| 646 | Phosphorylation | DLAAFADSANEEELQ HHHHHHHCCCHHHHH | 29.57 | 27821475 | |
| 666 | Ubiquitination | NTGISYEKEVASAAL CCCCCCHHHHHHHHH | 49.62 | 24961812 | |
| 681 | Ubiquitination | SELALGTKEHFLPYV HHHHHCCCHHCHHHH | 47.60 | 24961812 | |
| 693 | Ubiquitination | PYVEQSLKVLNEQVD HHHHHHHHHHHHHCC | 50.34 | 15699485 | |
| 702 | Phosphorylation | LNEQVDESYGLRETA HHHHCCHHHCCHHHH | 21.75 | 21126336 | |
| 718 | Ubiquitination | NTIWNVVKSVLLASK HHHHHHHHHHHHHCC | 30.48 | 17644757 | |
| 725 | Ubiquitination | KSVLLASKVEPESYP HHHHHHCCCCCCCCC | 45.04 | 23749301 | |
| 725 | Acetylation | KSVLLASKVEPESYP HHHHHHCCCCCCCCC | 45.04 | 24489116 | |
| 733 | Ubiquitination | VEPESYPKGIPASSY CCCCCCCCCCCHHHC | 62.33 | 17644757 | |
| 875 | Acetylation | VFGLFQSKSKNKRSS HHHHHCCCCCCCCHH | 55.45 | 24489116 | |
| 882 | Phosphorylation | KSKNKRSSAVGAASE CCCCCCHHHHHHHHH | 30.89 | 21440633 | |
| 913 | Phosphorylation | EALVIRLTSDKSLEV HHHHHHHHCCCCEEE | 25.65 | 28889911 | |
| 916 | Acetylation | VIRLTSDKSLEVRGN HHHHHCCCCEEECCC | 57.62 | 24489116 | |
| 916 | 2-Hydroxyisobutyrylation | VIRLTSDKSLEVRGN HHHHHCCCCEEECCC | 57.62 | - | |
| 948 | Ubiquitination | AVYEPVLKALYELLS HHHHHHHHHHHHHHH | 36.26 | 15699485 | |
| 960 | Ubiquitination | LLSAADQKALAAEDD HHHHHHHHHHHCCCH | 46.01 | 15699485 | |
| 1027 | Ubiquitination | PIFELIMKLYQENSP HHHHHHHHHHHHCCC | 36.73 | 17644757 | |
| 1053 | Ubiquitination | IFSAVFTKENDRIKL HHHHHHCCCCCCEEC | 42.95 | 17644757 | |
| 1086 | Acetylation | QTEEMKHKVIELLKY CHHHHHHHHHHHHHH | 39.11 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of IMB4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of IMB4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of IMB4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-646, AND MASSSPECTROMETRY. | |
