CG21_YEAST - dbPTM
CG21_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CG21_YEAST
UniProt AC P24868
Protein Name G2/mitotic-specific cyclin-1
Gene Name CLB1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 471
Subcellular Localization
Protein Description Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis..
Protein Sequence MSRSLLVENSRTINSNEEKGVNESQYILQKRNVPRTILGNVTNNANILQEISMNRKIGMKNFSKLNNFFPLKDDVSRADDFTSSFNDSRQGVKQEVLNNKENIPEYGYSEQEKQQCSNDDSFHTNSTALSCNRLIYSENKSISTQMEWQKKIMREDSKKKRPISTLVEQDDQKKFKLHELTTEEEVLEEYEWDDLDEEDCDDPLMVSEEVNDIFDYLHHLEIITLPNKANLYKHKNIKQNRDILVNWIIKIHNKFGLLPETLYLAINIMDRFLCEEVVQLNRLQLVGTSCLFIASKYEEIYSPSIKHFAYETDGACSVEDIKEGERFILEKLDFQISFANPMNFLRRISKADDYDIQSRTLAKFLMEISIVDFKFIGILPSLCASAAMFLSRKMLGKGTWDGNLIHYSGGYTKAKLYPVCQLLMDYLVGSTIHDEFLKKYQSRRFLKASIISIEWALKVRKNGYDIMTLHE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationEEKGVNESQYILQKR
CCCCCCHHHHHHHHC		24.0729136822
26PhosphorylationKGVNESQYILQKRNV
CCCCHHHHHHHHCCC		16.9329136822
121PhosphorylationQQCSNDDSFHTNSTA
HHCCCCCCCCCCHHH		23.0723749301
164PhosphorylationSKKKRPISTLVEQDD
HCCCCCCHHHCCCCC		20.5521440633
297PhosphorylationCLFIASKYEEIYSPS
HHHHHHCCHHHHCCC		19.1228889911
301PhosphorylationASKYEEIYSPSIKHF
HHCCHHHHCCCHHHH		20.1530377154
304PhosphorylationYEEIYSPSIKHFAYE
CHHHHCCCHHHHEEE		38.0330377154
310PhosphorylationPSIKHFAYETDGACS
CCHHHHEEECCCCCC		20.5828889911
312PhosphorylationIKHFAYETDGACSVE
HHHHEEECCCCCCHH		27.3628889911
317PhosphorylationYETDGACSVEDIKEG
EECCCCCCHHHHHCC		28.1828889911
381PhosphorylationKFIGILPSLCASAAM
HHCCHHHHHHHHHHH		32.4126447709
385PhosphorylationILPSLCASAAMFLSR
HHHHHHHHHHHHHHH		18.6326447709
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseAMA1P50082
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CG21_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CG21_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CKS1_YEASTCKS1physical
10688190
CG22_YEASTCLB2genetic
10445023
CG22_YEASTCLB2genetic
1849457
CG22_YEASTCLB2genetic
1427070
STE11_YEASTSTE11genetic
10512868
RAS2_YEASTRAS2genetic
10512868
PFD3_YEASTPAC10genetic
17314980
ENV11_YEASTENV11genetic
17314980
TAF12_YEASTTAF12genetic
17314980
SPT3_YEASTSPT3genetic
17314980
XRN1_YEASTXRN1genetic
17314980
CG24_YEASTCLB4genetic
18094053
CHK1_YEASTCHK1genetic
20093466
THRC_YEASTTHR4genetic
20093466
VAM7_YEASTVAM7genetic
20093466
SGF73_YEASTSGF73genetic
20093466
YIT6_YEASTYIR016Wgenetic
20093466
SAC1_YEASTSAC1genetic
20093466
SWI6_YEASTSWI6genetic
20093466
MCP1_YEASTMCP1genetic
20093466
CG22_YEASTCLB2genetic
20093466
CDK1_YEASTCDC28physical
20489023
CKS1_YEASTCKS1physical
20489023
LCB4_YEASTLCB4physical
20489023
SIC1_YEASTSIC1physical
20489023
TWF1_YEASTTWF1genetic
21127252
RAD51_YEASTRAD51genetic
21127252
PP2C1_YEASTPTC1genetic
21127252
DCC1_YEASTDCC1genetic
21127252
SPT2_YEASTSPT2genetic
21127252
SWE1_YEASTSWE1genetic
21795394
CG22_YEASTCLB2genetic
21978826
HIR1_YEASTHIR1genetic
21978826
SIC1_YEASTSIC1physical
21963604
RMRP_YEASTSNM1genetic
12136008
CHK1_YEASTCHK1genetic
22282571
CG22_YEASTCLB2genetic
27794027
SWI6_YEASTSWI6genetic
27708008
AGP1_YEASTAGP1genetic
27708008
THRC_YEASTTHR4genetic
27708008
ODO2_YEASTKGD2genetic
27708008
ATG1_YEASTATG1genetic
27708008
MDM34_YEASTMDM34genetic
27708008
SNF6_YEASTSNF6genetic
27708008
PMA2_YEASTPMA2genetic
27708008
CG22_YEASTCLB2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CG21_YEAST

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Related Literatures of Post-Translational Modification

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