| UniProt ID | CG22_YEAST | |
|---|---|---|
| UniProt AC | P24869 | |
| Protein Name | G2/mitotic-specific cyclin-2 | |
| Gene Name | CLB2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 491 | |
| Subcellular Localization | ||
| Protein Description | Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the CDC2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.. | |
| Protein Sequence | MSNPIENTENSQNTSSSRFLRNVQRLALNNVTNTTFQKSNANNPALTNFKSTLNSVKKEGSRIPQFTRESVSRSTAAQEEKRTLKENGIQLPKNNLLDDKENQDPSSQQFGALTSIKEGRAELPANISLQESSSAKEIIQHDPLKGVGSSTEVVHNSVENEKLHPARSQLQVRNTESETDSGKKRPISTIVEQELPKKFKVCDENGKEEYEWEDLDAEDVNDPFMVSEYVNDIFEYLHQLEVITLPKKEDLYQHRNIHQNRDILVNWLVKIHNKFGLLPETLYLAINIMDRFLGKELVQLDKLQLVGTSCLFIASKYEEVYSPSIKHFASETDGACTEDEIKEGEKFILKTLKFNLNYPNPMNFLRRISKADDYDIQSRTLAKFLLEISLVDFRFIGILPSLCAAAAMFMSRKMLGKGKWDGNLIHYSGGYTKEELAPVCHMIMDYLVSPIVHDEFHRKYQSRRFMKASIISVQWALKVRKNGYDIMTLHE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSNPIENTE ------CCCCCCCCC | 51.84 | 22814378 | |
| 128 | Phosphorylation | AELPANISLQESSSA CCCCCCCEECCCCCH | 24.65 | 21440633 | |
| 132 | Phosphorylation | ANISLQESSSAKEII CCCEECCCCCHHHHH | 19.34 | 29688323 | |
| 134 | Phosphorylation | ISLQESSSAKEIIQH CEECCCCCHHHHHHC | 53.27 | 21551504 | |
| 136 | Ubiquitination | LQESSSAKEIIQHDP ECCCCCHHHHHHCCC | 51.93 | 17644757 | |
| 145 | Ubiquitination | IIQHDPLKGVGSSTE HHHCCCCCCCCCCCC | 57.87 | 17644757 | |
| 149 | Phosphorylation | DPLKGVGSSTEVVHN CCCCCCCCCCCEEEC | 31.51 | 21551504 | |
| 162 | Ubiquitination | HNSVENEKLHPARSQ ECCCCCCCCCCCHHH | 64.77 | 17644757 | |
| 179 | Phosphorylation | VRNTESETDSGKKRP ECCCCCCCCCCCCCC | 44.75 | 24961812 | |
| 181 | Phosphorylation | NTESETDSGKKRPIS CCCCCCCCCCCCCCH | 60.99 | 24961812 | |
| 188 | Phosphorylation | SGKKRPISTIVEQEL CCCCCCCHHHHHCCC | 18.11 | 21440633 | |
| 189 | Phosphorylation | GKKRPISTIVEQELP CCCCCCHHHHHCCCC | 29.75 | 28889911 | |
| 411 | Phosphorylation | AAAAMFMSRKMLGKG HHHHHHHHHHHHCCC | 19.93 | 27017623 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CG22_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CG22_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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