| UniProt ID | SLI15_YEAST | |
|---|---|---|
| UniProt AC | P38283 | |
| Protein Name | Inner centromere protein-related protein SLI15 | |
| Gene Name | SLI15 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 698 | |
| Subcellular Localization | Nucleus . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Associates with the mitotic spindle and the kinetochore (PubMed:11724818). | |
| Protein Description | Required for high-fidelity chromosome segregation during the later part of each cell cycle in association with the protein kinase IPL1. Stimulates IPL1 kinase activity and facilitates its association with the mitotic spindle. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles.. | |
| Protein Sequence | MDWAIKAARKKTQRKPGSTRSIIETLDDLNNLTTDAHSEINQRLYESSEWLRNNVYMNTLKYEDKKMEESLISPENTHNKMDVEFPKMKGEYELSNSQNDAAKDVTKTPRNGLHNDKSITPKSLRRKEVTEGMNRFSIHDTNKSPVEPLNSVKVDANESEKSSPWSPYKVEKVLRESSKTSESPINTKRFDNQTWAAKEEMENEPILQALKKAESVKVKPPPNSGIARSQRRSNMFVPLPNKDPLIIQHIPPTKSSGSIPKVRTVKESPIAFKKKSTINSPAIRAVENSDTAGSTKASSVFDRLSSIPTKSFENKISRGNVGHKYSSSSIDLTGSPMKKVSQKFKSINSTDTDMQEALRDIFSVKNKITKNNSPKGKNSRKSSIPRFDKTSLKLTTHKKLAIIAEQKKKSKHSSDVHKTGSRPHSISPTKISVDSSSPSKEVKNYYQSPVRGYLRPTKASISPNKNKNLTTSQTPHRLKIKEKTLRKLSPNIADISKPESRKSKNYRLTNLQLLPPAEAERDDLKKKFDKRLSGIMRSQQEHHRRKQEKQKRMSHLEQDLKKQTSFSNDYKDIRLKESLAPFDNHVRDTINKNTAFSTDNILATINTVDHREIIGNVTPKIASVNDSLPEINTDSEDEASVTLAAWAKSPYLQEQLIRQQDINPQTIFGPIPPLHTDEIFPNPRLNRLKPRQIVPKRS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 70 | Phosphorylation | EDKKMEESLISPENT CCHHHHHHCCCCCCC | 20.07 | 19823750 | |
| 73 | Phosphorylation | KMEESLISPENTHNK HHHHHCCCCCCCCCC | 31.30 | 20377248 | |
| 77 | Phosphorylation | SLISPENTHNKMDVE HCCCCCCCCCCCCCC | 25.76 | 21440633 | |
| 87 | Ubiquitination | KMDVEFPKMKGEYEL CCCCCCCCCCCEEEC | 59.57 | 22817900 | |
| 89 | Ubiquitination | DVEFPKMKGEYELSN CCCCCCCCCEEECCC | 55.50 | 23749301 | |
| 95 | Phosphorylation | MKGEYELSNSQNDAA CCCEEECCCCCCHHH | 23.61 | 22369663 | |
| 97 | Phosphorylation | GEYELSNSQNDAAKD CEEECCCCCCHHHHH | 27.30 | 22369663 | |
| 106 | Phosphorylation | NDAAKDVTKTPRNGL CHHHHHCCCCCCCCC | 39.06 | 21440633 | |
| 108 | Phosphorylation | AAKDVTKTPRNGLHN HHHHCCCCCCCCCCC | 20.36 | 19823750 | |
| 118 | Phosphorylation | NGLHNDKSITPKSLR CCCCCCCCCCHHHHC | 34.26 | 20377248 | |
| 120 | Phosphorylation | LHNDKSITPKSLRRK CCCCCCCCHHHHCHH | 31.58 | 20377248 | |
| 123 | Phosphorylation | DKSITPKSLRRKEVT CCCCCHHHHCHHHHC | 28.45 | 23749301 | |
| 130 | Phosphorylation | SLRRKEVTEGMNRFS HHCHHHHCCCCCCCC | 28.10 | 28889911 | |
| 137 | Phosphorylation | TEGMNRFSIHDTNKS CCCCCCCCCCCCCCC | 18.77 | 20377248 | |
| 141 | Phosphorylation | NRFSIHDTNKSPVEP CCCCCCCCCCCCCCC | 30.31 | 21440633 | |
| 144 | Phosphorylation | SIHDTNKSPVEPLNS CCCCCCCCCCCCCCC | 35.93 | 21082442 | |
| 151 | Phosphorylation | SPVEPLNSVKVDANE CCCCCCCCEECCCCC | 30.88 | 24961812 | |
| 159 | Phosphorylation | VKVDANESEKSSPWS EECCCCCCCCCCCCC | 50.56 | 28889911 | |
| 162 | Phosphorylation | DANESEKSSPWSPYK CCCCCCCCCCCCHHH | 37.27 | 21440633 | |
| 163 | Phosphorylation | ANESEKSSPWSPYKV CCCCCCCCCCCHHHH | 41.26 | 21440633 | |
| 166 | Phosphorylation | SEKSSPWSPYKVEKV CCCCCCCCHHHHHHH | 23.03 | 21440633 | |
| 168 | Phosphorylation | KSSPWSPYKVEKVLR CCCCCCHHHHHHHHH | 23.34 | 19779198 | |
| 177 | Phosphorylation | VEKVLRESSKTSESP HHHHHHHCCCCCCCC | 30.60 | 22369663 | |
| 178 | Phosphorylation | EKVLRESSKTSESPI HHHHHHCCCCCCCCC | 34.89 | 20377248 | |
| 180 | Phosphorylation | VLRESSKTSESPINT HHHHCCCCCCCCCCC | 39.41 | 20377248 | |
| 181 | Phosphorylation | LRESSKTSESPINTK HHHCCCCCCCCCCCH | 39.55 | 22369663 | |
| 183 | Phosphorylation | ESSKTSESPINTKRF HCCCCCCCCCCCHHC | 30.74 | 22369663 | |
| 187 | Phosphorylation | TSESPINTKRFDNQT CCCCCCCCHHCCCCC | 25.06 | 22369663 | |
| 224 | Phosphorylation | KVKPPPNSGIARSQR CCCCCCCCCCCCCCC | 37.03 | 19779198 | |
| 233 | Phosphorylation | IARSQRRSNMFVPLP CCCCCCCCCCEEECC | 34.53 | 17287358 | |
| 264 | Phosphorylation | GSIPKVRTVKESPIA CCCCCEEECCCCCCC | 38.63 | 19823750 | |
| 268 | Phosphorylation | KVRTVKESPIAFKKK CEEECCCCCCCCCCC | 18.85 | 19823750 | |
| 280 | Phosphorylation | KKKSTINSPAIRAVE CCCCCCCCHHHHHHH | 16.32 | 21440633 | |
| 289 | Phosphorylation | AIRAVENSDTAGSTK HHHHHHCCCCCCCCH | 23.88 | 28889911 | |
| 294 | Phosphorylation | ENSDTAGSTKASSVF HCCCCCCCCHHHHHH | 25.03 | 28889911 | |
| 298 | Phosphorylation | TAGSTKASSVFDRLS CCCCCHHHHHHHHHH | 28.70 | 19684113 | |
| 299 | Phosphorylation | AGSTKASSVFDRLSS CCCCHHHHHHHHHHC | 31.50 | 28889911 | |
| 305 | Phosphorylation | SSVFDRLSSIPTKSF HHHHHHHHCCCCHHH | 27.41 | 23749301 | |
| 306 | Phosphorylation | SVFDRLSSIPTKSFE HHHHHHHCCCCHHHC | 36.86 | 24961812 | |
| 309 | Phosphorylation | DRLSSIPTKSFENKI HHHHCCCCHHHCCCC | 37.34 | 23749301 | |
| 311 | Phosphorylation | LSSIPTKSFENKISR HHCCCCHHHCCCCCC | 40.03 | 27017623 | |
| 317 | Phosphorylation | KSFENKISRGNVGHK HHHCCCCCCCCCCCC | 35.43 | 24961812 | |
| 324 | Acetylation | SRGNVGHKYSSSSID CCCCCCCCCCCCCCC | 40.68 | 25381059 | |
| 325 | Phosphorylation | RGNVGHKYSSSSIDL CCCCCCCCCCCCCCC | 14.22 | 21440633 | |
| 326 | Phosphorylation | GNVGHKYSSSSIDLT CCCCCCCCCCCCCCC | 28.66 | 28889911 | |
| 327 | Phosphorylation | NVGHKYSSSSIDLTG CCCCCCCCCCCCCCC | 25.64 | 24961812 | |
| 328 | Phosphorylation | VGHKYSSSSIDLTGS CCCCCCCCCCCCCCC | 25.93 | 24961812 | |
| 329 | Phosphorylation | GHKYSSSSIDLTGSP CCCCCCCCCCCCCCC | 23.28 | 28889911 | |
| 333 | Phosphorylation | SSSSIDLTGSPMKKV CCCCCCCCCCCCHHH | 31.68 | 28132839 | |
| 335 | Phosphorylation | SSIDLTGSPMKKVSQ CCCCCCCCCCHHHHH | 19.31 | 21440633 | |
| 341 | Phosphorylation | GSPMKKVSQKFKSIN CCCCHHHHHHHHHCC | 36.21 | 26447709 | |
| 379 | Phosphorylation | NSPKGKNSRKSSIPR CCCCCCCCCCCCCCC | 44.57 | 19823750 | |
| 382 | Phosphorylation | KGKNSRKSSIPRFDK CCCCCCCCCCCCCCC | 32.18 | 21440633 | |
| 383 | Phosphorylation | GKNSRKSSIPRFDKT CCCCCCCCCCCCCCC | 39.38 | 21440633 | |
| 419 | Phosphorylation | HSSDVHKTGSRPHSI CCCCCHHCCCCCCCC | 26.05 | 20377248 | |
| 421 | Phosphorylation | SDVHKTGSRPHSISP CCCHHCCCCCCCCCC | 48.12 | 20377248 | |
| 425 | Phosphorylation | KTGSRPHSISPTKIS HCCCCCCCCCCCEEE | 27.69 | 20377248 | |
| 427 | Phosphorylation | GSRPHSISPTKISVD CCCCCCCCCCEEEEC | 29.54 | 20377248 | |
| 429 | Phosphorylation | RPHSISPTKISVDSS CCCCCCCCEEEECCC | 33.93 | 19823750 | |
| 432 | Phosphorylation | SISPTKISVDSSSPS CCCCCEEEECCCCCC | 22.79 | 28889911 | |
| 435 | Phosphorylation | PTKISVDSSSPSKEV CCEEEECCCCCCHHH | 30.47 | 19823750 | |
| 436 | Phosphorylation | TKISVDSSSPSKEVK CEEEECCCCCCHHHH | 41.63 | 27214570 | |
| 437 | Phosphorylation | KISVDSSSPSKEVKN EEEECCCCCCHHHHH | 36.83 | 25521595 | |
| 439 | Phosphorylation | SVDSSSPSKEVKNYY EECCCCCCHHHHHHH | 43.31 | 24909858 | |
| 445 | Phosphorylation | PSKEVKNYYQSPVRG CCHHHHHHHCCCCCC | 9.36 | 28132839 | |
| 446 | Phosphorylation | SKEVKNYYQSPVRGY CHHHHHHHCCCCCCC | 16.35 | 28132839 | |
| 448 | Phosphorylation | EVKNYYQSPVRGYLR HHHHHHCCCCCCCCC | 14.83 | 22369663 | |
| 453 | Phosphorylation | YQSPVRGYLRPTKAS HCCCCCCCCCCCCCC | 6.75 | 19823750 | |
| 457 | Phosphorylation | VRGYLRPTKASISPN CCCCCCCCCCCCCCC | 32.58 | 21440633 | |
| 458 | Acetylation | RGYLRPTKASISPNK CCCCCCCCCCCCCCC | 42.70 | 24489116 | |
| 460 | Phosphorylation | YLRPTKASISPNKNK CCCCCCCCCCCCCCC | 25.75 | 23749301 | |
| 462 | Phosphorylation | RPTKASISPNKNKNL CCCCCCCCCCCCCCC | 21.67 | 21440633 | |
| 471 | Phosphorylation | NKNKNLTTSQTPHRL CCCCCCCCCCCCCHH | 23.23 | 28132839 | |
| 472 | Phosphorylation | KNKNLTTSQTPHRLK CCCCCCCCCCCCHHH | 27.16 | 28132839 | |
| 474 | Phosphorylation | KNLTTSQTPHRLKIK CCCCCCCCCCHHHCC | 22.34 | 23749301 | |
| 484 | Phosphorylation | RLKIKEKTLRKLSPN HHHCCHHHHHHHCCC | 32.65 | 21440633 | |
| 489 | Phosphorylation | EKTLRKLSPNIADIS HHHHHHHCCCHHHCC | 20.95 | 21082442 | |
| 509 | Phosphorylation | KSKNYRLTNLQLLPP CCCCCCCCCCEECCH | 25.53 | 21440633 | |
| 533 | Phosphorylation | KKFDKRLSGIMRSQQ HHHHHHHHHHHHHHH | 30.24 | 21440633 | |
| 546 | Ubiquitination | QQEHHRRKQEKQKRM HHHHHHHHHHHHHHH | 63.87 | 17644757 | |
| 549 | Ubiquitination | HHRRKQEKQKRMSHL HHHHHHHHHHHHHHH | 59.64 | 17644757 | |
| 551 | Ubiquitination | RRKQEKQKRMSHLEQ HHHHHHHHHHHHHHH | 62.22 | 17644757 | |
| 554 | Phosphorylation | QEKQKRMSHLEQDLK HHHHHHHHHHHHHHH | 29.02 | 19823750 | |
| 564 | Phosphorylation | EQDLKKQTSFSNDYK HHHHHHHHCCCCCHH | 40.39 | 21440633 | |
| 565 | Phosphorylation | QDLKKQTSFSNDYKD HHHHHHHCCCCCHHH | 24.96 | 21440633 | |
| 567 | Phosphorylation | LKKQTSFSNDYKDIR HHHHHCCCCCHHHHH | 28.67 | 28889911 | |
| 578 | Phosphorylation | KDIRLKESLAPFDNH HHHHHHHHHCCCCHH | 28.39 | 25704821 | |
| 589 | Phosphorylation | FDNHVRDTINKNTAF CCHHHHHHCCCCCCC | 18.84 | 21440633 | |
| 594 | Phosphorylation | RDTINKNTAFSTDNI HHHCCCCCCCCCCCE | 30.59 | 29688323 | |
| 597 | Phosphorylation | INKNTAFSTDNILAT CCCCCCCCCCCEEEE | 32.18 | 22369663 | |
| 598 | Phosphorylation | NKNTAFSTDNILATI CCCCCCCCCCEEEEE | 26.98 | 22369663 | |
| 604 | Phosphorylation | STDNILATINTVDHR CCCCEEEEEEECCHH | 16.00 | 29688323 | |
| 607 | Phosphorylation | NILATINTVDHREII CEEEEEEECCHHHHH | 24.38 | 29688323 | |
| 618 | Phosphorylation | REIIGNVTPKIASVN HHHHCCCCCCCCCCC | 23.90 | 27214570 | |
| 649 | Phosphorylation | TLAAWAKSPYLQEQL HHHHHHCCHHHHHHH | 15.84 | 24930733 | |
| 651 | Phosphorylation | AAWAKSPYLQEQLIR HHHHCCHHHHHHHHH | 28.27 | 19779198 | |
| 698 | Phosphorylation | RQIVPKRS------- HHCCCCCC------- | 51.18 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLI15_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLI15_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLI15_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97; SER-144; THR-309;SER-329; SER-489 AND SER-649, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233; SER-268 ANDSER-554, AND MASS SPECTROMETRY. | |
