TBB5_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TBB5_BOVIN
• UniProt AC: Q2KJD0
• Protein Name: Tubulin beta-5 chain
• Gene Name: TUBB5
• Organism: Bos taurus (Bovine).
• Sequence Length: 444
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)..
• Protein Sequence: MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEEDFGEEAEEEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	TGTYHGDSDLQLDRI CCCCCCCCCCEEEEE	44.83	-
55	Phosphorylation	SVYYNEATGGKYVPR EEEEECCCCCCCCCE	40.04	-
58	Acetylation	YNEATGGKYVPRAIL EECCCCCCCCCEEEE	44.40	-
58	Succinylation	YNEATGGKYVPRAIL EECCCCCCCCCEEEE	44.40	-
58	Succinylation	YNEATGGKYVPRAIL EECCCCCCCCCEEEE	44.40	-
107	Phosphorylation	NWAKGHYTEGAELVD CCCCCCCCCHHHHHH	23.44	-
172	Phosphorylation	NTFSVVPSPKVSDTV CCEECCCCCCCCCCE	26.24	-
285	Phosphorylation	SQQYRALTVPELTQQ CHHEEEEEHHHHHHH	32.79	-
290	Phosphorylation	ALTVPELTQQVFDAK EEEHHHHHHHHHHHH	18.46	-
318	Methylation	LTVAAVFRGRMSMKE EHHHHHHCCCCCHHH	25.80	-
438	5-glutamyl polyglutamate	EEEEDFGEEAEEEA- HHHHHHHHHHHHHC-	54.77	-
438	Formation of an isopeptide bond	EEEEDFGEEAEEEA- HHHHHHHHHHHHHC-	54.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
107	T	Phosphorylation	Kinase	LRRK2	Q5S007	PSP
172	S	Phosphorylation	Kinase	CDK1	P48734	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TBB5_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TBB5_BOVIN !!

Protein-Protein Interaction

Oops, there are no PPI records of TBB5_BOVIN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.