CWC22_YEAST - dbPTM
CWC22_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CWC22_YEAST
UniProt AC P53333
Protein Name Pre-mRNA-splicing factor CWC22
Gene Name CWC22
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 577
Subcellular Localization Cytoplasm . Nucleus .
Protein Description May be involved in pre-mRNA splicing..
Protein Sequence MSTATIQDEDIKFQRENWEMIRSHVSPIISNLTMDNLQESHRDLFQVNILIGRNIICKNVVDFTLNKQNGRLIPALSALIALLNSDIPDIGETLAKELMLMFVQQFNRKDYVSCGNILQCLSILFLYDVIHEIVILQILLLLLEKNSLRLVIAVMKICGWKLALVSKKTHDMIWEKLRYILQTQELSSTLRESLETLFEIRQKDYKSGSQGLFILDPTSYTVHTHSYIVSDEDEANKELGNFEKCENFNELTMAFDTLRQKLLINNTSDTNEGSNSQLQIYDMTSTNDVEFKKKIYLVLKSSLSGDEAAHKLLKLKIANNLKKSVVDIIIKSSLQESTFSKFYSILSERMITFHRSWQTAYNETFEQNYTQDIEDYETDQLRILGKFWGHLISYEFLPMDCLKIIKLTEEESCPQGRIFIKFLFQELVNELGLDELQLRLNSSKLDGMFPLEGDAEHIRYSINFFTAIGLGLLTEDMRSRLTIIQEVEDAEEEEKKLREEEELEKLRKKARESQPTQGPKIHESRLFLQKDTRENSRSRSPFTVETRKRARSRTPPRGSRNHRNRSRTPPARRQRHR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
296PhosphorylationVEFKKKIYLVLKSSL
CCHHHEEEEEEHHCC		10.3125533186
516PhosphorylationKARESQPTQGPKIHE
HHHHHCCCCCCCHHH		38.2219779198
524PhosphorylationQGPKIHESRLFLQKD
CCCCHHHHHHEEECC		21.8119779198
538PhosphorylationDTRENSRSRSPFTVE
CCCCCCCCCCCCCHH		36.6129136822
540PhosphorylationRENSRSRSPFTVETR
CCCCCCCCCCCHHHH		26.1321082442
543PhosphorylationSRSRSPFTVETRKRA
CCCCCCCCHHHHHHH		22.3319779198
568PhosphorylationNHRNRSRTPPARRQR
CCCCCCCCCCHHHHH		34.5728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CWC22_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CWC22_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CWC22_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SCM4_YEASTSCM4physical
10688190
SN114_YEASTSNU114physical
16554755
PRP19_YEASTPRP19physical
16554755
CLF1_YEASTCLF1physical
16554755
EIF3B_YEASTPRT1physical
16554755
BRR2_YEASTBRR2physical
16429126
CEF1_YEASTCEF1physical
16429126
CLF1_YEASTCLF1physical
16429126
SF3B1_YEASTHSH155physical
16429126
PRP46_YEASTPRP46physical
16429126
PRP8_YEASTPRP8physical
16429126
SN114_YEASTSNU114physical
16429126
SYF1_YEASTSYF1physical
16429126
PRP19_YEASTPRP19physical
16429126
RRP8_YEASTRRP8genetic
19061648
SAC3_YEASTSAC3genetic
19061648
MRT4_YEASTMRT4genetic
19061648
SSB1_YEASTSSB1physical
19536198
VAB2_YEASTVAB2physical
22875988
RPB7_YEASTRPB7genetic
27708008
SGF11_YEASTSGF11genetic
27708008
DPOA2_YEASTPOL12genetic
27708008
AAR2_YEASTAAR2genetic
27708008
POP7_YEASTPOP7genetic
27708008
SLU7_YEASTSLU7genetic
27708008
SYF1_YEASTSYF1genetic
27708008
GPI19_YEASTGPI19genetic
27708008
MOB2_YEASTMOB2genetic
27708008
ACT_YEASTACT1genetic
27708008
PRP43_YEASTPRP43genetic
27708008
PRP18_YEASTPRP18genetic
27708008
PRI1_YEASTPRI1genetic
27708008
PRI2_YEASTPRI2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
SN114_YEASTSNU114genetic
27708008
COFI_YEASTCOF1genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CDC45_YEASTCDC45genetic
27708008
CLF1_YEASTCLF1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
RSE1_YEASTRSE1genetic
27708008
CEF1_YEASTCEF1genetic
27708008
PRP24_YEASTPRP24genetic
27708008
NOG2_YEASTNOG2genetic
27708008
PROF_YEASTPFY1genetic
27708008
SYA_YEASTALA1genetic
27708008
IF6_YEASTTIF6genetic
27708008
RDS3_YEASTRDS3genetic
27708008
PRP4_YEASTPRP4genetic
27708008
SEC23_YEASTSEC23genetic
27708008
SHE1_YEASTSHE1genetic
27708008
URA7_YEASTURA7genetic
27708008
PIN4_YEASTPIN4genetic
27708008
MRC1_YEASTMRC1genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
BUD31_YEASTBUD31genetic
27708008
PAT1_YEASTPAT1genetic
27708008
DLD1_YEASTDLD1genetic
27708008
UGA4_YEASTUGA4genetic
27708008
VPS41_YEASTVPS41genetic
27708008
XRN1_YEASTXRN1genetic
27708008
CWC26_YEASTBUD13genetic
27708008
TAD1_YEASTTAD1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
IST3_YEASTIST3genetic
27708008
LSM1_YEASTLSM1genetic
27708008
SWE1_YEASTSWE1genetic
27708008
ISY1_YEASTISY1genetic
27708008
RL14A_YEASTRPL14Agenetic
27708008
FABG_YEASTOAR1genetic
27708008
PIR3_YEASTPIR3genetic
27708008
YRA2_YEASTYRA2genetic
27708008
PML1_YEASTPML1genetic
27708008
RAX2_YEASTRAX2genetic
27708008
ACE2_YEASTACE2genetic
27708008
SPSY_YEASTSPE4genetic
27708008
PFD6_YEASTYKE2genetic
27708008
OST6_YEASTOST6genetic
27708008
CSM3_YEASTCSM3genetic
27708008
CTL1_YEASTCTL1genetic
27708008
SKY1_YEASTSKY1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
EOS1_YEASTEOS1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
HUB1_YEASTHUB1genetic
27708008
HST3_YEASTHST3genetic
27708008
FYV12_YEASTFYV12genetic
27708008
VPH1_YEASTVPH1genetic
27708008
SNU66_YEASTSNU66genetic
27708008
YP014_YEASTYPL014Wgenetic
27708008
CWC27_YEASTCWC27genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
RU2A_YEASTLEA1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CWC22_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-538 AND SER-540, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-540, AND MASSSPECTROMETRY.

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