| UniProt ID | CDC45_YEAST | |
|---|---|---|
| UniProt AC | Q08032 | |
| Protein Name | Cell division control protein 45 | |
| Gene Name | CDC45 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 650 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for initiation of chromosomal DNA replication. Acts at the origin of replication. Also has a role in minichromosome maintenance.. | |
| Protein Sequence | MYYGISQFSEAYNKILRNSSSHSSCQLVIFVSCLNIDALCATKMLSLLFKKQLVQSQIVPIFGYSELRRHYSQLDDNINSLLLVGFGGVIDLEAFLEIDPQEYVIDTDEKSGEQSFRRDIYVLDAHRPWNLDNIFGSQIIQCFDDGTVDDTLGEQKEAYYKLLELDEESGDDELSGDENDNNGGDDEATDADEVTDEDEEDEDETISNKRGNSSIGPNDLSKRKQRKKQIHEYEGVLEEYYSQGTTVVNSISAQIYSLLSAIGETNLSNLWLNILGTTSLDIAYAQVYNRLYPLLQDEVKRLTPSSRNSVKTPDTLTLNIQPDYYLFLLRHSSLYDSFYYSNYVNAKLSLWNENGKKRLHKMFARMGIPLSTAQETWLYMDHSIKRELGIIFDKNLDRYGLQDIIRDGFVRTLGYRGSISASEFVEALTALLEVGNSTDKDSVKINNDNNDDTDGEEEEDNSAQKLTNLRKRWVSNFWLSWDALDDRKVELLNRGIQLAQDLQRAIFNTGVAILEKKLIKHLRIYRLCVLQDGPDLDLYRNPLTLLRLGNWLIECCAESEDKQLLPMVLASIDENTDTYLVAGLTPRYPRGLDTIHTKKPILNNFSMAFQQITAETDAKVRIDNFESSIIEIRREDLSPFLEKLTLSGLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MYYGISQFSE -----CCCCHHHHHH | 13.49 | 28889911 | |
| 46 | Phosphorylation | LCATKMLSLLFKKQL HHHHHHHHHHHHHHH | 21.37 | 27017623 | |
| 213 | Phosphorylation | ISNKRGNSSIGPNDL CCCCCCCCCCCCCHH | 26.59 | 28889911 | |
| 214 | Phosphorylation | SNKRGNSSIGPNDLS CCCCCCCCCCCCHHH | 35.25 | 25752575 | |
| 221 | Phosphorylation | SIGPNDLSKRKQRKK CCCCCHHHHHHHHHH | 33.02 | 29688323 | |
| 394 | Ubiquitination | ELGIIFDKNLDRYGL HHCEEECCCHHHHCH | 48.97 | 24961812 | |
| 453 | Phosphorylation | NNDNNDDTDGEEEED CCCCCCCCCCCHHHC | 49.09 | 25521595 | |
| 571 | Phosphorylation | LLPMVLASIDENTDT HHHHHHHHCCCCCCC | 26.81 | 29688323 | |
| 576 | Phosphorylation | LASIDENTDTYLVAG HHHCCCCCCCEEEEC | 27.89 | 29688323 | |
| 578 | Phosphorylation | SIDENTDTYLVAGLT HCCCCCCCEEEECCC | 19.40 | 29688323 | |
| 579 | Phosphorylation | IDENTDTYLVAGLTP CCCCCCCEEEECCCC | 11.29 | 29688323 | |
| 585 | Phosphorylation | TYLVAGLTPRYPRGL CEEEECCCCCCCCCC | 12.56 | 29688323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CDC45_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CDC45_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CDC45_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213; SER-214 ANDTHR-453, AND MASS SPECTROMETRY. | |
