DPB2_YEAST - dbPTM
DPB2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DPB2_YEAST
UniProt AC P24482
Protein Name DNA polymerase epsilon subunit B
Gene Name DPB2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 689
Subcellular Localization Cytoplasm . Nucleus .
Protein Description DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair..
Protein Sequence MFGSGNVLPVKIQPPLLRPLAYRVLSRKYGLSIKSDGLSALAEFVGTNIGANWRQGPATIKFLEQFAAVWKQQERGLFIDQSGVKEVIQEMKEREKVEWSHEHPIQHEENILGRTDDDENNSDDEMPIAADSSLQNVSLSSPMRQPTERDEYKQPFKPESSKALDWRDYFKVINASQQQRFSYNPHKMQFIFVPNKKQNGLGGIAGFLPDIEDKVQMFLTRYYLTNDRVMRNENFQNSDMFNPLSSMVSLQNELSNTNRQQQSSSMSITPIKNLLGRDAQNFLLLGLLNKNFKGNWSLEDPSGSVEIDISQTIPTQGHYYVPGCMVLVEGIYYSVGNKFHVTSMTLPPGERREITLETIGNLDLLGIHGISNNNFIARLDKDLKIRLHLLEKELTDHKFVILGANLFLDDLKIMTALSKILQKLNDDPPTLLIWQGSFTSVPVFASMSSRNISSSTQFKNNFDALATLLSRFDNLTENTTMIFIPGPNDLWGSMVSLGASGTLPQDPIPSAFTKKINKVCKNVVWSSNPTRIAYLSQEIVIFRDDLSGRFKRHRLEFPFNESEDVYTENDNMMSKDTDIVPIDELVKEPDQLPQKVQETRKLVKTILDQGHLSPFLDSLRPISWDLDHTLTLCPIPSTMVLCDTTSAQFDLTYNGCKVINPGSFIHNRRARYMEYVPSSKKTIQEEIYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MFGSGNVLPVK
----CCCCCCEECCC		18.8730377154
115PhosphorylationEENILGRTDDDENNS
CHHCCCCCCCCCCCC		41.8228132839
122PhosphorylationTDDDENNSDDEMPIA
CCCCCCCCCCCCCCC		59.0023749301
138PhosphorylationDSSLQNVSLSSPMRQ
CCCCCCCCCCCCCCC		30.0427017623
141PhosphorylationLQNVSLSSPMRQPTE
CCCCCCCCCCCCCCC		28.1914747467
238PhosphorylationRNENFQNSDMFNPLS
CCCCCCCCCCCCHHH		21.4827017623
246PhosphorylationDMFNPLSSMVSLQNE
CCCCHHHHHHHHHHH		30.7727017623
255PhosphorylationVSLQNELSNTNRQQQ
HHHHHHHHCCCHHHH		35.1127017623
392AcetylationIRLHLLEKELTDHKF
HHHHHHHHHCCCCCE		58.9824489116
415PhosphorylationLDDLKIMTALSKILQ
HHHHHHHHHHHHHHH		28.1126447709
419UbiquitinationKIMTALSKILQKLND
HHHHHHHHHHHHHCC		48.5724961812
613PhosphorylationILDQGHLSPFLDSLR
HHHCCCCHHHHHHCC		14.1314747467
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
141SPhosphorylationKinaseCDC28P00546
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
141SPhosphorylation

14747467
613SPhosphorylation

14747467
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DPB2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DPB4_YEASTDPB4physical
11805826
DPOE_YEASTPOL2physical
11805826
PSF1_YEASTPSF1physical
12730134
DPB11_YEASTDPB11physical
12665575
DPB2_YEASTDPB2physical
12665575
DPOE_YEASTPOL2physical
12665575
TRF5_YEASTTRF5physical
12665575
DPB2_YEASTDPB2physical
10878005
DPOE_YEASTPOL2physical
10878005
DPOE_YEASTPOL2physical
9792727
DPB4_YEASTDPB4physical
10878005
DPB3_YEASTDPB3physical
10878005
DPOE_YEASTPOL2physical
15824130
CTF8_YEASTCTF8physical
15824130
DPB3_YEASTDPB3physical
15824130
DPB4_YEASTDPB4physical
15824130
DPB11_YEASTDPB11genetic
8524850
MBA1_YEASTMBA1physical
16554755
STE50_YEASTSTE50physical
16554755
RPN4_YEASTRPN4physical
16554755
PBP4_YEASTPBP4physical
16554755
CBS1_YEASTCBS1physical
16554755
DPB4_YEASTDPB4physical
16554755
HMO1_YEASTHMO1physical
16554755
LEUC_YEASTLEU1physical
16554755
IF4F2_YEASTTIF4632physical
16554755
UTP22_YEASTUTP22physical
16554755
YG36_YEASTYGR126Wphysical
16554755
LSM12_YEASTLSM12physical
16554755
DBP4_YEASTHCA4physical
16554755
DOA1_YEASTDOA1physical
16554755
STM1_YEASTSTM1physical
16554755
IMDH3_YEASTIMD3physical
16554755
ORC1_YEASTORC1physical
16554755
NOP12_YEASTNOP12physical
16554755
TMA46_YEASTTMA46physical
16554755
EIF3B_YEASTPRT1physical
16554755
RRP12_YEASTRRP12physical
16554755
NOP53_YEASTNOP53physical
16554755
ORC4_YEASTORC4physical
16554755
DPOE_YEASTPOL2physical
16429126
DED1_YEASTDED1physical
16429126
DPB4_YEASTDPB4physical
16429126
IMDH3_YEASTIMD3physical
16429126
PABP_YEASTPAB1physical
16429126
RS4A_YEASTRPS4Aphysical
16429126
RS4B_YEASTRPS4Aphysical
16429126
DPOE_YEASTPOL2genetic
18245343
MSH6_YEASTMSH6genetic
18245343
DPOE_YEASTPOL2physical
18245343
MRC1_YEASTMRC1physical
18851837
DPOE_YEASTPOL2physical
19463834
HOG1_YEASTHOG1physical
19477922
CDC45_YEASTCDC45physical
19496828
DPOZ_YEASTREV3genetic
22709919
DPOE_YEASTPOL2genetic
22709919
PCNA_YEASTPOL30genetic
22709919
DPOE_YEASTPOL2physical
23034803
DPB3_YEASTDPB3physical
23034803
DPB4_YEASTDPB4physical
23034803
PSF1_YEASTPSF1physical
23499531
PSF2_YEASTPSF2physical
23499531
PSF3_YEASTPSF3physical
23499531
SLD5_YEASTSLD5physical
23499531
DDC1_YEASTDDC1genetic
28107343
NRM1_YEASTNRM1genetic
28107343
CTF4_YEASTCTF4physical
27397685
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DPB2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Cell cycle-dependent phosphorylation of the DNA polymerase epsilonsubunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase.";
Kesti T., McDonald W.H., Yates J.R. III, Wittenberg C.;
J. Biol. Chem. 279:14245-14255(2004).
Cited for: PROTEIN SEQUENCE OF 132-144 AND 606-622, PHOSPHORYLATION AT SER-141AND SER-613, AND MASS SPECTROMETRY.

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