| UniProt ID | DBP4_YEAST | |
|---|---|---|
| UniProt AC | P20448 | |
| Protein Name | ATP-dependent RNA helicase HCA4 | |
| Gene Name | HCA4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 770 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2.. | |
| Protein Sequence | MAKKNRLNTTQRKTLRQKEDEYIENLKTKIDEYDPKITKAKFFKDLPISDPTLKGLRESSFIKLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEFDGLGALIISPTRELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFELERISRINILIGTPGRILQHLDQAVGLNTSNLQMLVLDEADRCLDMGFKKTLDAIVSTLSPSRQTLLFSATQSQSVADLARLSLTDYKTVGTHDVMDGSVNKEASTPETLQQFYIEVPLADKLDILFSFIKSHLKCKMIVFLSSSKQVHFVYETFRKMQPGISLMHLHGRQKQRARTETLDKFNRAQQVCLFATDVVARGIDFPAVDWVVQVDCPEDVDTYIHRVGRCARYGKKGKSLIMLTPQEQEAFLKRLNARKIEPGKLNIKQSKKKSIKPQLQSLLFKDPELKYLGQKAFISYVRSIYVQKDKQVFKFDELPTEEFAYSLGLPGAPKIKMKGMKTIEQAKERKNAPRQLAFLSKANEDGEVIEDKSKQPRTKYDKMFERKNQTILSEHYLNITKAQAQEDEDDDFISVKRKDHEINEAELPALTLPTSRRAQKKALSKKASLASKGNASKLIFDDEGEAHPVYELEDEEEFHKRGDAEVQKTEFLTKESAVMADIDNIDKQVAKEKKQEKKRKRLEAMRREMEAAMEEEISGDEEEGKTVAYLGTGNLSDDMSDGDMPDSEGHLKKKARTVDYSHGHNPSNSVDDDIIEVEEPQTLEDLESLTAKLIQG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 44 | Acetylation | ITKAKFFKDLPISDP CCHHHHCCCCCCCCC | 62.58 | 24489116 | |
| 59 | Phosphorylation | TLKGLRESSFIKLTE CCCCHHHCCCEEEEE | 24.90 | 22890988 | |
| 60 | Phosphorylation | LKGLRESSFIKLTEI CCCHHHCCCEEEEEE | 26.66 | 22890988 | |
| 87 | Phosphorylation | DVLAAAKTGSGKTLA HEEEEEECCCCCHHH | 31.67 | 19823750 | |
| 89 | Phosphorylation | LAAAKTGSGKTLAFL EEEEECCCCCHHHHH | 42.20 | 19823750 | |
| 92 | Phosphorylation | AKTGSGKTLAFLVPV EECCCCCHHHHHHHH | 27.18 | 19823750 | |
| 134 | Phosphorylation | MQIYEVLTKIGSHTS HHHHHHHHHHCCCCC | 26.28 | 28889911 | |
| 213 | Phosphorylation | KTLDAIVSTLSPSRQ HHHHHHHHHCCCCHH | 19.95 | 30377154 | |
| 214 | Phosphorylation | TLDAIVSTLSPSRQT HHHHHHHHCCCCHHH | 21.99 | 30377154 | |
| 216 | Phosphorylation | DAIVSTLSPSRQTLL HHHHHHCCCCHHHCC | 22.40 | 28889911 | |
| 221 | Phosphorylation | TLSPSRQTLLFSATQ HCCCCHHHCCEEECC | 25.07 | 28889911 | |
| 225 | Phosphorylation | SRQTLLFSATQSQSV CHHHCCEEECCCCCH | 30.31 | 28889911 | |
| 231 | Phosphorylation | FSATQSQSVADLARL EEECCCCCHHHHHHC | 25.23 | 28889911 | |
| 255 | Phosphorylation | THDVMDGSVNKEAST CCCCCCCCCCCCCCC | 20.46 | 30377154 | |
| 422 | Acetylation | EPGKLNIKQSKKKSI CCCCCCCCHHCCCCC | 47.66 | 25381059 | |
| 439 | Acetylation | QLQSLLFKDPELKYL HHHHHHHCCHHHHHH | 72.79 | 24489116 | |
| 449 | Acetylation | ELKYLGQKAFISYVR HHHHHCHHHHHHHHH | 43.39 | 24489116 | |
| 495 | Acetylation | KIKMKGMKTIEQAKE CCCCCCCHHHHHHHH | 55.83 | 25381059 | |
| 501 | Acetylation | MKTIEQAKERKNAPR CHHHHHHHHHCCCCH | 58.72 | 25381059 | |
| 568 | Phosphorylation | DEDDDFISVKRKDHE CCCCCCEEEEECCCC | 22.91 | 25704821 | |
| 570 | Acetylation | DDDFISVKRKDHEIN CCCCEEEEECCCCCC | 47.11 | 23572591 | |
| 572 | Ubiquitination | DFISVKRKDHEINEA CCEEEEECCCCCCHH | 58.69 | 19722269 | |
| 642 | Acetylation | RGDAEVQKTEFLTKE HCCHHHHHHHEECHH | 56.02 | 24489116 | |
| 648 | Acetylation | QKTEFLTKESAVMAD HHHHEECHHHHHHHC | 52.39 | 25381059 | |
| 692 | Phosphorylation | AAMEEEISGDEEEGK HHHHHHHCCCCCCCC | 43.39 | 17330950 | |
| 700 | Phosphorylation | GDEEEGKTVAYLGTG CCCCCCCEEEEEECC | 22.64 | 19795423 | |
| 703 | Phosphorylation | EEGKTVAYLGTGNLS CCCCEEEEEECCCCC | 11.00 | 19823750 | |
| 706 | Phosphorylation | KTVAYLGTGNLSDDM CEEEEEECCCCCCCC | 21.94 | 20377248 | |
| 710 | Phosphorylation | YLGTGNLSDDMSDGD EEECCCCCCCCCCCC | 35.25 | 22369663 | |
| 714 | Phosphorylation | GNLSDDMSDGDMPDS CCCCCCCCCCCCCCC | 45.49 | 22369663 | |
| 721 | Phosphorylation | SDGDMPDSEGHLKKK CCCCCCCCCCHHHHH | 39.34 | 20377248 | |
| 731 | Phosphorylation | HLKKKARTVDYSHGH HHHHHEEECCCCCCC | 23.69 | 29688323 | |
| 734 | Phosphorylation | KKARTVDYSHGHNPS HHEEECCCCCCCCCC | 9.76 | 21440633 | |
| 735 | Phosphorylation | KARTVDYSHGHNPSN HEEECCCCCCCCCCC | 20.66 | 21551504 | |
| 741 | Phosphorylation | YSHGHNPSNSVDDDI CCCCCCCCCCCCCCC | 47.24 | 21440633 | |
| 743 | Phosphorylation | HGHNPSNSVDDDIIE CCCCCCCCCCCCCEE | 31.12 | 21440633 | |
| 756 | Phosphorylation | IEVEEPQTLEDLESL EEECCCCCHHHHHHH | 42.71 | 29688323 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DBP4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DBP4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DBP4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-692; SER-710AND SER-714, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-692, AND MASSSPECTROMETRY. | |
