TRX1_YEAST - dbPTM
TRX1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRX1_YEAST
UniProt AC P22217
Protein Name Thioredoxin-1
Gene Name TRX1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 103
Subcellular Localization Nucleus . Cytoplasm . Golgi apparatus membrane
Peripheral membrane protein . Mitochondrion intermembrane space .
Protein Description Participates as a hydrogen donor in redox reactions through the reversible oxidation of its active center dithiol to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. It is involved in many cellular processes, including deoxyribonucleotide synthesis, repair of oxidatively damaged proteins, protein folding, sulfur metabolism, and redox homeostasis. Thioredoxin-dependent enzymes include phosphoadenosine-phosphosulfate reductase MET16, alkyl-hydroperoxide reductase DOT5, thioredoxin peroxidases TSA1 and TSA2, alkyl hydroperoxide reductase AHP1, and peroxiredoxin HYR1. Thioredoxin is also involved in protection against reducing stress. As part of the LMA1 complex, it is involved in the facilitation of vesicle fusion such as homotypic vacuole and ER-derived COPII vesicle fusion with the Golgi. This activity does not require the redox mechanism..
Protein Sequence MVTQFKTASEFDSAIAQDKLVVVDFYATWCGPCKMIAPMIEKFSEQYPQADFYKLDVDELGDVAQKNEVSAMPTLLLFKNGKEVAKVVGANPAAIKQAIAANA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Ubiquitination--MVTQFKTASEFDS
--CCCCCCCHHHHHH		33.1124961812
7Phosphorylation-MVTQFKTASEFDSA
-CCCCCCCHHHHHHH		36.3822369663
9PhosphorylationVTQFKTASEFDSAIA
CCCCCCHHHHHHHHH		43.9922369663
13PhosphorylationKTASEFDSAIAQDKL
CCHHHHHHHHHHCCE		27.2228889911
42AcetylationMIAPMIEKFSEQYPQ
HHHHHHHHHHHHCCC		43.1724489116
54UbiquitinationYPQADFYKLDVDELG
CCCCCEEECCHHHHH		37.9023749301
54AcetylationYPQADFYKLDVDELG
CCCCCEEECCHHHHH		37.9024489116
54SuccinylationYPQADFYKLDVDELG
CCCCCEEECCHHHHH		37.9023954790
66UbiquitinationELGDVAQKNEVSAMP
HHHHHHHHCCCCCCC		45.3923749301
70PhosphorylationVAQKNEVSAMPTLLL
HHHHCCCCCCCEEEE		16.8127017623
79AcetylationMPTLLLFKNGKEVAK
CCEEEEEECCCHHHH		65.8322865919
86UbiquitinationKNGKEVAKVVGANPA
ECCCHHHHHHCCCHH		42.5023749301
86AcetylationKNGKEVAKVVGANPA
ECCCHHHHHHCCCHH		42.5024489116
96UbiquitinationGANPAAIKQAIAANA
CCCHHHHHHHHHHCC		29.0223749301
96AcetylationGANPAAIKQAIAANA
CCCHHHHHHHHHHCC		29.0224489116
96SuccinylationGANPAAIKQAIAANA
CCCHHHHHHHHHHCC		29.0223954790
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRX1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRX1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRX1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NYV1_YEASTNYV1physical
9657146
SEC18_YEASTSEC18physical
9657146
VAM3_YEASTVAM3physical
9657146
AHP1_YEASTAHP1physical
16272220
MET16_YEASTMET16physical
16272220
MSRA_YEASTMXR1physical
16272220
TSA1_YEASTTSA1physical
16272220
TRX2_YEASTTRX2genetic
10844700
GLRX1_YEASTGRX1genetic
10844700
GLRX2_YEASTGRX2genetic
10844700
TRX2_YEASTTRX2genetic
9501259
TRX2_YEASTTRX2genetic
8930901
TRX2_YEASTTRX2genetic
7929110
GSHR_YEASTGLR1genetic
8930901
TRX2_YEASTTRX2genetic
16272220
TRX2_YEASTTRX2genetic
16574642
TRX2_YEASTTRX2genetic
2026619
TRX2_YEASTTRX2genetic
21623372
CSG2_YEASTCSG2genetic
21623372
DHE4_YEASTGDH1genetic
21623372
TRX2_YEASTTRX2genetic
23416294
TRX2_YEASTTRX2genetic
25247923
TRX2_YEASTTRX2genetic
22878414
TIM10_YEASTTIM10physical
22878414
VPS41_YEASTVPS41genetic
27708008
UME6_YEASTUME6genetic
27708008
TRX2_YEASTTRX2genetic
27708008
DAL81_YEASTDAL81genetic
27708008
SST2_YEASTSST2genetic
27708008
SUR1_YEASTSUR1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
DDT4L_HUMANDDIT4Lphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRX1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9 AND SER-13, AND MASSSPECTROMETRY.

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