AHP1_YEAST - dbPTM
AHP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AHP1_YEAST
UniProt AC P38013
Protein Name Peroxiredoxin AHP1 {ECO:0000305}
Gene Name AHP1 {ECO:0000303|PubMed:9988687}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 176
Subcellular Localization Cytoplasm .
Protein Description Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Preferentially eliminates organic peroxides rather than hydrogen peroxide. [PubMed: 10391912]
Protein Sequence MSDLVNKKFPAGDYKFQYIAISQSDADSESCKMPQTVEWSKLISENKKVIITGAPAAFSPTCTVSHIPGYINYLDELVKEKEVDQVIVVTVDNPFANQAWAKSLGVKDTTHIKFASDPGCAFTKSIGFELAVGDGVYWSGRWAMVVENGIVTYAAKETNPGTDVTVSSVESVLAHL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDLVNKKF
------CCHHCCCCC		39.3815665377
2Acetylation------MSDLVNKKF
------CCHHCCCCC		39.38-
7Succinylation-MSDLVNKKFPAGDY
-CCHHCCCCCCCCCC		48.5923954790
7Acetylation-MSDLVNKKFPAGDY
-CCHHCCCCCCCCCC		48.5924489116
8UbiquitinationMSDLVNKKFPAGDYK
CCHHCCCCCCCCCCE		51.9123749301
8AcetylationMSDLVNKKFPAGDYK
CCHHCCCCCCCCCCE		51.9124489116
15AcetylationKFPAGDYKFQYIAIS
CCCCCCCEEEEEEEE		30.6324489116
15UbiquitinationKFPAGDYKFQYIAIS
CCCCCCCEEEEEEEE		30.6317644757
22PhosphorylationKFQYIAISQSDADSE
EEEEEEEECCCCCCC		18.0117287358
24PhosphorylationQYIAISQSDADSESC
EEEEEECCCCCCCCC		28.1623749301
28PhosphorylationISQSDADSESCKMPQ
EECCCCCCCCCCCCC		32.8820377248
30PhosphorylationQSDADSESCKMPQTV
CCCCCCCCCCCCCCH		24.0020377248
32AcetylationDADSESCKMPQTVEW
CCCCCCCCCCCCHHH		64.0024489116
32UbiquitinationDADSESCKMPQTVEW
CCCCCCCCCCCCHHH		64.0023749301
36PhosphorylationESCKMPQTVEWSKLI
CCCCCCCCHHHHHHH		17.9622369663
40PhosphorylationMPQTVEWSKLISENK
CCCCHHHHHHHCCCC		12.2221440633
412-HydroxyisobutyrylationPQTVEWSKLISENKK
CCCHHHHHHHCCCCC		51.41-
41UbiquitinationPQTVEWSKLISENKK
CCCHHHHHHHCCCCC		51.4124961812
41AcetylationPQTVEWSKLISENKK
CCCHHHHHHHCCCCC		51.4124489116
44PhosphorylationVEWSKLISENKKVII
HHHHHHHCCCCCEEE		45.6219795423
47SuccinylationSKLISENKKVIITGA
HHHHCCCCCEEEECC		44.3523954790
47UbiquitinationSKLISENKKVIITGA
HHHHCCCCCEEEECC		44.3522817900
47AcetylationSKLISENKKVIITGA
HHHHCCCCCEEEECC		44.3525381059
472-HydroxyisobutyrylationSKLISENKKVIITGA
HHHHCCCCCEEEECC		44.35-
48UbiquitinationKLISENKKVIITGAP
HHHCCCCCEEEECCC		50.6923749301
59PhosphorylationTGAPAAFSPTCTVSH
ECCCCCCCCCEEHHC		17.9920377248
61PhosphorylationAPAAFSPTCTVSHIP
CCCCCCCCEEHHCCC		21.4321440633
65PhosphorylationFSPTCTVSHIPGYIN
CCCCEEHHCCCCHHH		9.5021440633
79AcetylationNYLDELVKEKEVDQV
HHHHHHHHHCCCCEE		75.5725381059
79UbiquitinationNYLDELVKEKEVDQV
HHHHHHHHHCCCCEE		75.5717644757
102UbiquitinationFANQAWAKSLGVKDT
HHCHHHHHHCCCCCC		35.2023749301
103PhosphorylationANQAWAKSLGVKDTT
HCHHHHHHCCCCCCC		23.7021440633
107AcetylationWAKSLGVKDTTHIKF
HHHHCCCCCCCEEEE		47.7822865919
107UbiquitinationWAKSLGVKDTTHIKF
HHHHCCCCCCCEEEE		47.7823749301
1072-HydroxyisobutyrylationWAKSLGVKDTTHIKF
HHHHCCCCCCCEEEE		47.78-
107SuccinylationWAKSLGVKDTTHIKF
HHHHCCCCCCCEEEE		47.7823954790
113UbiquitinationVKDTTHIKFASDPGC
CCCCCEEEECCCCCC		27.5523749301
113AcetylationVKDTTHIKFASDPGC
CCCCCEEEECCCCCC		27.5524489116
116PhosphorylationTTHIKFASDPGCAFT
CCEEEECCCCCCCEE		47.6921440633
123PhosphorylationSDPGCAFTKSIGFEL
CCCCCCEECEECCEE		12.8321440633
124UbiquitinationDPGCAFTKSIGFELA
CCCCCEECEECCEEE		33.3517644757
156UbiquitinationGIVTYAAKETNPGTD
CEEEEEECCCCCCCC		57.8217644757
158PhosphorylationVTYAAKETNPGTDVT
EEEEECCCCCCCCCC		46.1122369663
162PhosphorylationAKETNPGTDVTVSSV
ECCCCCCCCCCHHHH		28.6722369663
165PhosphorylationTNPGTDVTVSSVESV
CCCCCCCCHHHHHHH		19.9222369663
167PhosphorylationPGTDVTVSSVESVLA
CCCCCCHHHHHHHHH		21.2122369663
168PhosphorylationGTDVTVSSVESVLAH
CCCCCHHHHHHHHHC		26.1022369663
171PhosphorylationVTVSSVESVLAHL--
CCHHHHHHHHHCC--		21.9222369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AHP1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AHP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AHP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
URM1_YEASTURM1physical
14555475
AHP1_YEASTAHP1physical
9888818
SSB2_YEASTSSB2physical
16554755
AP2_YEASTCAD1physical
20145245
PRX1_YEASTPRX1genetic
21282621
GPX2_YEASTGPX2genetic
21282621
GPX1_YEASTGPX1genetic
21282621
GPX3_YEASTHYR1genetic
21282621
TRX2_YEASTTRX2physical
22474296
AHP1_YEASTAHP1physical
22474296
SDHX_YEASTYJL045Wgenetic
27708008
FLR1_YEASTFLR1genetic
27708008
YBM3_YEASTYBR013Cgenetic
27708008
PP2C4_YEASTPTC4genetic
27708008
RIM1_YEASTRIM1genetic
27708008
PAT1_YEASTPAT1genetic
27708008
AIM7_YEASTAIM7genetic
27708008
RPA14_YEASTRPA14genetic
27708008
MCM21_YEASTMCM21genetic
27708008
SNF1_YEASTSNF1genetic
27708008
RAD4_YEASTRAD4genetic
27708008
YG21_YEASTYGR053Cgenetic
27708008
BUB1_YEASTBUB1genetic
27708008
MGA1_YEASTMGA1genetic
27708008
VPS29_YEASTVPS29genetic
27708008
NIT1_YEASTNIT1genetic
27708008
BNA3_YEASTBNA3genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
TSA1_YEASTTSA1genetic
27708008
MLH1_YEASTMLH1genetic
27708008
MAS5_YEASTYDJ1genetic
27708008
FRE7_YEASTFRE7genetic
27708008
BUB3_YEASTBUB3genetic
27708008
SERC_YEASTSER1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
THI22_YEASTTHI22genetic
27708008
URN1_YEASTURN1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AHP1_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION AT SER-2,AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-171, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION AT SER-2,AND MASS SPECTROMETRY.

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