PRX1_YEAST - dbPTM
PRX1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRX1_YEAST
UniProt AC P34227
Protein Name Peroxiredoxin PRX1, mitochondrial {ECO:0000305}
Gene Name PRX1 {ECO:0000303|PubMed:10821871}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 261
Subcellular Localization Mitochondrion .
Protein Description Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Involved in mitochondrial protection of cadmium-induced oxidative stress..
Protein Sequence MFSRICSAQLKRTAWTLPKQAHLQSQTIKTFATAPILCKQFKQSDQPRLRINSDAPNFDADTTVGKINFYDYLGDSWGVLFSHPADFTPVCTTEVSAFAKLKPEFDKRNVKLIGLSVEDVESHEKWIQDIKEIAKVKNVGFPIIGDTFRNVAFLYDMVDAEGFKNINDGSLKTVRSVFVIDPKKKIRLIFTYPSTVGRNTSEVLRVIDALQLTDKEGVVTPINWQPADDVIIPPSVSNDEAKAKFGQFNEIKPYLRFTKSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationQPRLRINSDAPNFDA
CCCEEECCCCCCCCC		32.5528889911
91GlutathionylationPADFTPVCTTEVSAF
CCCCCCEECCCHHHH		4.0322833525
107AcetylationKLKPEFDKRNVKLIG
HCCCCHHHCCEEEEE		51.7122865919
125AcetylationEDVESHEKWIQDIKE
HHHHHHHHHHHHHHH		44.1424489116
131AcetylationEKWIQDIKEIAKVKN
HHHHHHHHHHHCCCC		51.8924489116
131SuccinylationEKWIQDIKEIAKVKN
HHHHHHHHHHHCCCC		51.8923954790
137AcetylationIKEIAKVKNVGFPII
HHHHHCCCCCCCCEE		45.2524489116
173PhosphorylationINDGSLKTVRSVFVI
CCCCCCCEEEEEEEE		26.8425005228
176PhosphorylationGSLKTVRSVFVIDPK
CCCCEEEEEEEECCC		18.6425005228
183AcetylationSVFVIDPKKKIRLIF
EEEEECCCCCEEEEE		64.0524489116
183SuccinylationSVFVIDPKKKIRLIF
EEEEECCCCCEEEEE		64.0523954790
244AcetylationSNDEAKAKFGQFNEI
CCHHHHHHHCCCCCC		49.6924489116
252AcetylationFGQFNEIKPYLRFTK
HCCCCCCHHHEEECC		22.7924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRX1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRX1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRX1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBP4_YEASTDOA4physical
11805826
PRX1_YEASTPRX1physical
18552404
DER1_YEASTDER1genetic
20093466
SLX5_YEASTSLX5genetic
20093466
OMS1_YEASTOMS1genetic
20093466
PHB2_YEASTPHB2genetic
20093466
SNF6_YEASTSNF6genetic
20093466
THIK_YEASTPOT1genetic
20093466
GYP6_YEASTGYP6genetic
20093466
MRT4_YEASTMRT4genetic
20093466
CAF4_YEASTCAF4genetic
20093466
TOM70_YEASTTOM70genetic
20093466
OCA1_YEASTOCA1genetic
20093466
ISU1_YEASTISU1genetic
20093466
THDH_YEASTILV1genetic
21623372
AHP1_YEASTAHP1genetic
21282621
GPX2_YEASTGPX2genetic
21282621
GPX1_YEASTGPX1genetic
21282621
GPX3_YEASTHYR1genetic
21282621
RM40_YEASTMRPL40physical
21779004
RM04_YEASTMRPL4physical
21779004
RM41_YEASTMRP20physical
21779004
RM49_YEASTMRP49physical
21779004
RM02_YEASTMRP7physical
21779004
RM36_YEASTMRPL36physical
21779004
TRX3_YEASTTRX3physical
22770501
PRX1_YEASTPRX1physical
26159064
SLX5_YEASTSLX5genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SNF6_YEASTSNF6genetic
27708008
MRT4_YEASTMRT4genetic
27708008
UBX2_YEASTUBX2genetic
27708008
ISU1_YEASTISU1genetic
27708008
SLX5_YEASTSLX5genetic
29674565
FEN1_YEASTRAD27genetic
29674565
CSK22_YEASTCKA2genetic
29674565
RPC1_YEASTRPO31genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRX1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Profiling phosphoproteins of yeast mitochondria reveals a role ofphosphorylation in assembly of the ATP synthase.";
Reinders J., Wagner K., Zahedi R.P., Stojanovski D., Eyrich B.,van der Laan M., Rehling P., Sickmann A., Pfanner N., Meisinger C.;
Mol. Cell. Proteomics 6:1896-1906(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53, AND MASSSPECTROMETRY.

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