GPX2_YEAST - dbPTM
GPX2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPX2_YEAST
UniProt AC P38143
Protein Name Glutathione peroxidase-like peroxiredoxin 2 {ECO:0000303|PubMed:10480913}
Gene Name GPX2 {ECO:0000303|PubMed:10480913}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 162
Subcellular Localization Cytoplasm . Nucleus . Mitochondrion outer membrane
Peripheral membrane protein
Cytoplasmic side . Mitochondrion inner membrane
Peripheral membrane protein
Matrix side .
Protein Description Glutathione peroxidase-like protein that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress. [PubMed: 10480913]
Protein Sequence MTTSFYDLECKDKKGESFKFDQLKGKVVLIVNVASKCGFTPQYKELEELYKKYQDKGFVILGFPCNQFGKQEPGSDEQITEFCQLNYGVTFPIMKKIDVNGSNADSVYNYLKSQKAGLLGFKGIKWNFEKFLVDSNGKVVQRFSSLTKPSSLDQEIQSLLSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MTTSFYDLE
------CCCEEEEEE		31.0228889911
3Phosphorylation-----MTTSFYDLEC
-----CCCEEEEEEE		18.6228889911
4Phosphorylation----MTTSFYDLECK
----CCCEEEEEEEC		16.7928889911
56AcetylationLYKKYQDKGFVILGF
HHHHHCCCCEEEEEE		38.4324489116
102PhosphorylationKKIDVNGSNADSVYN
EEEECCCCCHHHHHH		24.5228889911
106PhosphorylationVNGSNADSVYNYLKS
CCCCCHHHHHHHHHH		24.8828889911
108PhosphorylationGSNADSVYNYLKSQK
CCCHHHHHHHHHHCC		11.3128889911
110PhosphorylationNADSVYNYLKSQKAG
CHHHHHHHHHHCCCC		9.6028889911
112AcetylationDSVYNYLKSQKAGLL
HHHHHHHHHCCCCCC		40.2424489116
113PhosphorylationSVYNYLKSQKAGLLG
HHHHHHHHCCCCCCC		34.0317563356
122AcetylationKAGLLGFKGIKWNFE
CCCCCCCCCCCEEEE		58.9124489116
125AcetylationLLGFKGIKWNFEKFL
CCCCCCCCEEEEEEE		44.7624489116
130AcetylationGIKWNFEKFLVDSNG
CCCEEEEEEEECCCC		39.6024489116
138AcetylationFLVDSNGKVVQRFSS
EEECCCCCEEEEHHH		43.4124489116
148AcetylationQRFSSLTKPSSLDQE
EEHHHCCCCCCHHHH		48.4724489116
150PhosphorylationFSSLTKPSSLDQEIQ
HHHCCCCCCHHHHHH		45.1222369663
158PhosphorylationSLDQEIQSLLSK---
CHHHHHHHHHCC---		36.6222369663
161PhosphorylationQEIQSLLSK------
HHHHHHHCC------		41.4322369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPX2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPX2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPX2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLF1_YEASTCLF1physical
10688190
TPO3_YEASTTPO3physical
18467557
FMP45_YEASTFMP45physical
18467557
SFK1_YEASTSFK1physical
18467557
PDR12_YEASTPDR12physical
18467557
MUP1_YEASTMUP1physical
18467557
CSM1_YEASTCSM1physical
18719252
YL345_YEASTYLR345Wphysical
18719252
OLA1_YEASTOLA1genetic
20093466
UBC4_YEASTUBC4genetic
20093466
RIM1_YEASTRIM1genetic
20093466
THRC_YEASTTHR4genetic
20093466
PEX19_YEASTPEX19genetic
20093466
YD179_YEASTYDR179W-Agenetic
20093466
YG34_YEASTYGR122Wgenetic
20093466
AIM20_YEASTAIM20genetic
20093466
MTC1_YEASTMTC1genetic
20093466
COX12_YEASTCOX12genetic
20093466
SRN2_YEASTSRN2genetic
20093466
PEX13_YEASTPEX13genetic
20093466
SST2_YEASTSST2genetic
20093466
IMP2_YEASTIMP2genetic
20093466
EAF7_YEASTEAF7genetic
20093466
BRE5_YEASTBRE5genetic
20093466
WHI5_YEASTWHI5genetic
20093466
COQ7_YEASTCAT5genetic
20093466
MNE1_YEASTMNE1genetic
20093466
MDL2_YEASTMDL2genetic
20093466
SPEE_YEASTSPE3genetic
20093466
YPR09_YEASTYPR109Wgenetic
20093466
COX5A_YEASTCOX5Agenetic
21623372
ATPK_YEASTATP17genetic
21623372
GPX3_YEASTHYR1genetic
21282621
GPX3_YEASTHYR1genetic
22659048
TPO3_YEASTTPO3physical
22615397
ACK1_YEASTACK1genetic
27708008
KTR7_YEASTKTR7genetic
27708008
HAP3_YEASTHAP3genetic
27708008
IMG2_YEASTIMG2genetic
27708008
PEX19_YEASTPEX19genetic
27708008
VMA21_YEASTVMA21genetic
27708008
MTC1_YEASTMTC1genetic
27708008
PEX1_YEASTPEX1genetic
27708008
PAM17_YEASTPAM17genetic
27708008
LIPB_YEASTLIP2genetic
27708008
ATP10_YEASTATP10genetic
27708008
IMP2_YEASTIMP2genetic
27708008
EAF7_YEASTEAF7genetic
27708008
BRE5_YEASTBRE5genetic
27708008
MDL2_YEASTMDL2genetic
27708008
SPEE_YEASTSPE3genetic
27708008
YPR09_YEASTYPR109Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPX2_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2 AND SER-4, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113, AND MASSSPECTROMETRY.

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