MUP1_YEAST - dbPTM
MUP1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MUP1_YEAST
UniProt AC P50276
Protein Name High-affinity methionine permease
Gene Name MUP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 574
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description High affinity permease for methionine..
Protein Sequence MSEGRTFLSQLNVFNKENYQFSSSTTKKEVSNSTVDADNGASDFEAGQQFATELDQGEKQLGILSCIGLICNRMLGTGVFAVSSTIYTLCGSVGLALIMWAVGAIIAISGLYVYMEFGTAIPKNGGEKNYLEAIFRKPKFFITCMYAAYIFFLGWAAGNSINTAIMFLTAADTEVTKWNQRGIGVAVVFFAFLINSLNVKIGLYLQNILGIFKIGIVLFISITGWVALGGGLKDGYQSHNFRNAFEGTETATAYGIVNALYSVIWSFVGYSNVNYALGEVKNPVRTLKIAGPTSMVFLAIIYIFVNIAYFAVVPKDKLISSKLILAADFFDIVFGGQAKRAAAALVGLSALGNVLSVIFSQGRIIQQLGREGVLPFSNFFASSKPFNSPMVGLFQHFIVCTVTILAPPPGDAYLLVQNLISYPMNIINFAISAGLLWIYWQRRQGKIEWNPPIKAGVFVTGFFTLSNLYLIIAPYVPPSNGESVYSSMPYWIHCVIAWGIFFFGGVYYVVWAQLLPRWGHYKLVSKDVLGEDGFWRVKIAKVYDDTIGDVDTQEDGVIETNIIEHYKSEQEKSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16UbiquitinationSQLNVFNKENYQFSS
HHHHCCCCCCCCCCC		35.5523749301
23PhosphorylationKENYQFSSSTTKKEV
CCCCCCCCCCCCCCC		32.7519779198
25PhosphorylationNYQFSSSTTKKEVSN
CCCCCCCCCCCCCCC		44.5819779198
27UbiquitinationQFSSSTTKKEVSNST
CCCCCCCCCCCCCCE		47.2023749301
28UbiquitinationFSSSTTKKEVSNSTV
CCCCCCCCCCCCCEE		62.3423749301
33PhosphorylationTKKEVSNSTVDADNG
CCCCCCCCEECCCCC		23.4621551504
34PhosphorylationKKEVSNSTVDADNGA
CCCCCCCEECCCCCC		27.0124961812
42PhosphorylationVDADNGASDFEAGQQ
ECCCCCCCHHHHHHH		44.2028152593
526UbiquitinationGHYKLVSKDVLGEDG
CCEEEEECHHHCCCC		44.3623749301
543PhosphorylationRVKIAKVYDDTIGDV
EEEEEEEECCCCCCC		13.8524961812
546PhosphorylationIAKVYDDTIGDVDTQ
EEEEECCCCCCCCCC		24.7819779198
552PhosphorylationDTIGDVDTQEDGVIE
CCCCCCCCCCCCEEE		33.4322369663
560PhosphorylationQEDGVIETNIIEHYK
CCCCEEEHHHHHHHH		22.1623749301
566PhosphorylationETNIIEHYKSEQEKS
EHHHHHHHHHHHHHC		11.9228889911
567UbiquitinationTNIIEHYKSEQEKSL
HHHHHHHHHHHHHCC		49.8023749301
568PhosphorylationNIIEHYKSEQEKSL-
HHHHHHHHHHHHCC-		37.0328889911
572UbiquitinationHYKSEQEKSL-----
HHHHHHHHCC-----		57.6723749301
573PhosphorylationYKSEQEKSL------
HHHHHHHCC------		38.2623749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MUP1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MUP1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEO1_YEASTSEO1genetic
8893857
MUP1_YEASTMUP1physical
18467557
SNA3_YEASTSNA3physical
18467557
VHT1_YEASTVHT1physical
18467557
YOR1_YEASTYOR1physical
18467557
HXT5_YEASTHXT5physical
18467557
HXT1_YEASTHXT1physical
18467557
HXT2_YEASTHXT2physical
18467557
PPZ1_YEASTPPZ1physical
18467557
YMP0_YEASTYMR010Wphysical
18467557
PDR12_YEASTPDR12physical
18467557
DYN3_YEASTDYN3physical
18467557
YL413_YEASTINA1physical
18467557
TCB3_YEASTTCB3physical
18467557
SLM1_YEASTSLM1physical
18467557
TPO3_YEASTTPO3physical
18467557
DIP5_YEASTDIP5physical
18467557
DUR3_YEASTDUR3physical
18467557
TPO1_YEASTTPO1physical
18467557
SFK1_YEASTSFK1physical
18467557
WSC3_YEASTWSC3physical
18467557
OSH7_YEASTOSH7physical
18467557
MEP3_YEASTMEP3physical
18467557
TPO4_YEASTTPO4physical
18467557
TPO2_YEASTTPO2physical
18467557
YG3A_YEASTYGR130Cphysical
18467557
MID2_YEASTMID2physical
18467557
MEP1_YEASTMEP1physical
18467557
MSC3_YEASTMSC3physical
18467557
YL326_YEASTYLR326Wphysical
18467557
WSC2_YEASTWSC2physical
18467557
FLC1_YEASTFLC1physical
18467557
LSP1_YEASTLSP1physical
18467557
QDR2_YEASTQDR2physical
18467557
LYP1_YEASTLYP1physical
18467557
LDB19_YEASTLDB19physical
18976803
SWD1_YEASTSWD1genetic
20093466
GAL10_YEASTGAL10genetic
20093466
ARL1_YEASTARL1genetic
20093466
HSP79_YEASTSSE2genetic
20093466
PTP1_YEASTPTP1genetic
20093466
DOT1_YEASTDOT1genetic
20093466
PHB2_YEASTPHB2genetic
20093466
SNX4_YEASTSNX4genetic
20093466
PET10_YEASTPET10genetic
20093466
MMM1_YEASTMMM1genetic
20093466
PAU4_YEASTPAU4genetic
20093466
ATG16_YEASTATG16genetic
20093466
NSG2_YEASTNSG2genetic
20093466
YNM2_YEASTYNL122Cgenetic
20093466
SKI7_YEASTSKI7genetic
20093466
METK1_YEASTSAM1genetic
20693451
GSH1_YEASTGSH1genetic
21623372
ATPO_YEASTATP5genetic
21623372
COX5A_YEASTCOX5Agenetic
21623372
CSG2_YEASTCSG2genetic
21623372
SSB1_YEASTSSB1physical
22940862
HSP72_YEASTSSA2physical
22940862
HSP71_YEASTSSA1physical
22940862
BET3_YEASTBET3genetic
27708008
MCM1_YEASTMCM1genetic
27708008
TYSY_YEASTCDC21genetic
27708008
DED1_YEASTDED1genetic
27708008
KPC1_YEASTPKC1genetic
27708008
UAP1_YEASTQRI1genetic
27708008
CDC13_YEASTCDC13genetic
27708008
DBF4_YEASTDBF4genetic
27708008
LCB2_YEASTLCB2genetic
27708008
CDC1_YEASTCDC1genetic
27708008
SRPR_YEASTSRP101genetic
27708008
GPI11_YEASTGPI11genetic
27708008
GPI19_YEASTGPI19genetic
27708008
RMRP_YEASTSNM1genetic
27708008
ACT_YEASTACT1genetic
27708008
SYMC_YEASTMES1genetic
27708008
CP51_YEASTERG11genetic
27708008
GPI16_YEASTGPI16genetic
27708008
GPI13_YEASTGPI13genetic
27708008
SYFB_YEASTFRS1genetic
27708008
ERG27_YEASTERG27genetic
27708008
NEP1_YEASTEMG1genetic
27708008
UTP13_YEASTUTP13genetic
27708008
AFG2_YEASTAFG2genetic
27708008
RSE1_YEASTRSE1genetic
27708008
HMCS_YEASTERG13genetic
27708008
GPI12_YEASTGPI12genetic
27708008
HAS1_YEASTHAS1genetic
27708008
LST8_YEASTLST8genetic
27708008
NOG2_YEASTNOG2genetic
27708008
GPI2_YEASTGPI2genetic
27708008
TF2B_YEASTSUA7genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
CP56_YEASTDIT2genetic
27708008
PHB2_YEASTPHB2genetic
27708008
SNX4_YEASTSNX4genetic
27708008
MMM1_YEASTMMM1genetic
27708008
CSF1_YEASTCSF1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
UBX2_YEASTUBX2genetic
27708008
EOS1_YEASTEOS1genetic
27708008
LDB19_YEASTLDB19genetic
27798240
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MUP1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-552, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-552, AND MASSSPECTROMETRY.

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