| UniProt ID | PPZ1_YEAST | |
|---|---|---|
| UniProt AC | P26570 | |
| Protein Name | Serine/threonine-protein phosphatase PP-Z1 | |
| Gene Name | PPZ1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 692 | |
| Subcellular Localization | ||
| Protein Description | Essential for the maintenance of cell size and integrity in response to osmotic stress.. | |
| Protein Sequence | MGNSSSKSSKKDSHSNSSSRNPRPQVSRTETSHSVKSAKSNKSSRSRRSLPSSSTTNTNSNVPDPSTPSKPNLEVNHQRHSSHTNRYHFPSSSHSHSNSQNELLTTPSSSSTKRPSTSRRSSYNTKAAADLPPSMIQMEPKSPILKTNNSSTHVSKHKSSYSSTYYENALTDDDNDDKDNDISHTKRFSRSSNSRPSSIRSGSVSRRKSDVTHEEPNNGSYSSNNQENYLVQALTRSNSHASSLHSRKSSFGSDGNTAYSTPLNSPGLSKLTDHSGEYFTSNSTSSLNHHSSRDIYPSKHISNDDDIENSSQLSNIHASMENVNDKNNNITDSKKDPNEEFNDIMQSSGNKNAPKKFKKPIDIDETIQKLLDAGYAAKRTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSAALKQVMKKGRQERKLANQQQQMMETSITNDNESQQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Myristoylation | ------MGNSSSKSS ------CCCCCCCCC | 42.60 | - | |
| 31 | Phosphorylation | PQVSRTETSHSVKSA CCCCCCCCCHHHHHH | 31.00 | 30377154 | |
| 32 | Phosphorylation | QVSRTETSHSVKSAK CCCCCCCCHHHHHHC | 13.92 | 19684113 | |
| 34 | Phosphorylation | SRTETSHSVKSAKSN CCCCCCHHHHHHCCC | 30.89 | 25752575 | |
| 37 | Phosphorylation | ETSHSVKSAKSNKSS CCCHHHHHHCCCCCC | 38.48 | 19684113 | |
| 40 | Phosphorylation | HSVKSAKSNKSSRSR HHHHHHCCCCCCCCC | 49.56 | 30377154 | |
| 49 | Phosphorylation | KSSRSRRSLPSSSTT CCCCCCCCCCCCCCC | 43.45 | 17330950 | |
| 52 | Phosphorylation | RSRRSLPSSSTTNTN CCCCCCCCCCCCCCC | 42.06 | 29136822 | |
| 53 | Phosphorylation | SRRSLPSSSTTNTNS CCCCCCCCCCCCCCC | 29.75 | 29136822 | |
| 54 | Phosphorylation | RRSLPSSSTTNTNSN CCCCCCCCCCCCCCC | 43.52 | 29136822 | |
| 55 | Phosphorylation | RSLPSSSTTNTNSNV CCCCCCCCCCCCCCC | 26.47 | 19779198 | |
| 56 | Phosphorylation | SLPSSSTTNTNSNVP CCCCCCCCCCCCCCC | 41.83 | 19779198 | |
| 58 | Phosphorylation | PSSSTTNTNSNVPDP CCCCCCCCCCCCCCC | 37.62 | 19779198 | |
| 60 | Phosphorylation | SSTTNTNSNVPDPST CCCCCCCCCCCCCCC | 36.85 | 29136822 | |
| 66 | Phosphorylation | NSNVPDPSTPSKPNL CCCCCCCCCCCCCCC | 61.40 | 29136822 | |
| 67 | Phosphorylation | SNVPDPSTPSKPNLE CCCCCCCCCCCCCCE | 36.65 | 29136822 | |
| 69 | Phosphorylation | VPDPSTPSKPNLEVN CCCCCCCCCCCCEEC | 61.91 | 29136822 | |
| 70 | Ubiquitination | PDPSTPSKPNLEVNH CCCCCCCCCCCEECC | 38.85 | 17644757 | |
| 87 | Phosphorylation | HSSHTNRYHFPSSSH CCCCCCCCCCCCCCC | 15.19 | 26447709 | |
| 91 | Phosphorylation | TNRYHFPSSSHSHSN CCCCCCCCCCCCCCC | 43.46 | 23749301 | |
| 92 | Phosphorylation | NRYHFPSSSHSHSNS CCCCCCCCCCCCCCC | 32.10 | 30377154 | |
| 93 | Phosphorylation | RYHFPSSSHSHSNSQ CCCCCCCCCCCCCCC | 33.09 | 28889911 | |
| 95 | Phosphorylation | HFPSSSHSHSNSQNE CCCCCCCCCCCCCCC | 30.47 | 23749301 | |
| 97 | Phosphorylation | PSSSHSHSNSQNELL CCCCCCCCCCCCCCC | 40.99 | 23749301 | |
| 99 | Phosphorylation | SSHSHSNSQNELLTT CCCCCCCCCCCCCCC | 37.08 | 23749301 | |
| 105 | Phosphorylation | NSQNELLTTPSSSST CCCCCCCCCCCCCCC | 49.65 | 26447709 | |
| 106 | Phosphorylation | SQNELLTTPSSSSTK CCCCCCCCCCCCCCC | 22.57 | 23749301 | |
| 108 | Phosphorylation | NELLTTPSSSSTKRP CCCCCCCCCCCCCCC | 40.54 | 23749301 | |
| 109 | Phosphorylation | ELLTTPSSSSTKRPS CCCCCCCCCCCCCCC | 29.52 | 23749301 | |
| 110 | Phosphorylation | LLTTPSSSSTKRPST CCCCCCCCCCCCCCC | 46.49 | 19779198 | |
| 111 | Phosphorylation | LTTPSSSSTKRPSTS CCCCCCCCCCCCCCC | 39.64 | 28889911 | |
| 112 | Phosphorylation | TTPSSSSTKRPSTSR CCCCCCCCCCCCCCC | 32.78 | 23749301 | |
| 116 | Phosphorylation | SSSTKRPSTSRRSSY CCCCCCCCCCCCCCC | 42.94 | 27717283 | |
| 117 | Phosphorylation | SSTKRPSTSRRSSYN CCCCCCCCCCCCCCC | 29.00 | 27717283 | |
| 118 | Phosphorylation | STKRPSTSRRSSYNT CCCCCCCCCCCCCCH | 29.99 | 27717283 | |
| 121 | Phosphorylation | RPSTSRRSSYNTKAA CCCCCCCCCCCHHHH | 35.74 | 27717283 | |
| 122 | Phosphorylation | PSTSRRSSYNTKAAA CCCCCCCCCCHHHHH | 22.16 | 28889911 | |
| 123 | Phosphorylation | STSRRSSYNTKAAAD CCCCCCCCCHHHHHC | 28.26 | 27717283 | |
| 125 | Phosphorylation | SRRSSYNTKAAADLP CCCCCCCHHHHHCCC | 17.52 | 27717283 | |
| 134 | Phosphorylation | AAADLPPSMIQMEPK HHHCCCHHHEECCCC | 26.95 | 21440633 | |
| 141 | Ubiquitination | SMIQMEPKSPILKTN HHEECCCCCCCCCCC | 56.40 | 22817900 | |
| 142 | Phosphorylation | MIQMEPKSPILKTNN HEECCCCCCCCCCCC | 28.08 | 25752575 | |
| 146 | Acetylation | EPKSPILKTNNSSTH CCCCCCCCCCCCCCC | 50.34 | 25381059 | |
| 146 | Ubiquitination | EPKSPILKTNNSSTH CCCCCCCCCCCCCCC | 50.34 | 23749301 | |
| 147 | Phosphorylation | PKSPILKTNNSSTHV CCCCCCCCCCCCCCC | 35.87 | 23749301 | |
| 150 | Phosphorylation | PILKTNNSSTHVSKH CCCCCCCCCCCCCCC | 38.39 | 27214570 | |
| 151 | Phosphorylation | ILKTNNSSTHVSKHK CCCCCCCCCCCCCCC | 25.34 | 27717283 | |
| 152 | Phosphorylation | LKTNNSSTHVSKHKS CCCCCCCCCCCCCCC | 26.56 | 25752575 | |
| 159 | Phosphorylation | THVSKHKSSYSSTYY CCCCCCCCCCCCCCH | 33.94 | 21551504 | |
| 160 | Phosphorylation | HVSKHKSSYSSTYYE CCCCCCCCCCCCCHH | 33.56 | 26447709 | |
| 161 | Phosphorylation | VSKHKSSYSSTYYEN CCCCCCCCCCCCHHC | 17.46 | 26447709 | |
| 162 | Phosphorylation | SKHKSSYSSTYYENA CCCCCCCCCCCHHCC | 20.39 | 21440633 | |
| 163 | Phosphorylation | KHKSSYSSTYYENAL CCCCCCCCCCHHCCC | 16.52 | 19779198 | |
| 164 | Phosphorylation | HKSSYSSTYYENALT CCCCCCCCCHHCCCC | 24.96 | 26447709 | |
| 165 | Phosphorylation | KSSYSSTYYENALTD CCCCCCCCHHCCCCC | 15.66 | 19779198 | |
| 166 | Phosphorylation | SSYSSTYYENALTDD CCCCCCCHHCCCCCC | 11.64 | 21440633 | |
| 171 | Phosphorylation | TYYENALTDDDNDDK CCHHCCCCCCCCCCC | 34.66 | 22369663 | |
| 178 | Ubiquitination | TDDDNDDKDNDISHT CCCCCCCCCCCCCHH | 62.38 | 23749301 | |
| 183 | Phosphorylation | DDKDNDISHTKRFSR CCCCCCCCHHHHHCC | 28.15 | 23749301 | |
| 185 | Phosphorylation | KDNDISHTKRFSRSS CCCCCCHHHHHCCCC | 19.68 | 28889911 | |
| 191 | Phosphorylation | HTKRFSRSSNSRPSS HHHHHCCCCCCCCCC | 32.45 | 22369663 | |
| 192 | Phosphorylation | TKRFSRSSNSRPSSI HHHHCCCCCCCCCCC | 37.40 | 23749301 | |
| 194 | Phosphorylation | RFSRSSNSRPSSIRS HHCCCCCCCCCCCCC | 47.73 | 22369663 | |
| 197 | Phosphorylation | RSSNSRPSSIRSGSV CCCCCCCCCCCCCCC | 36.97 | 22369663 | |
| 198 | Phosphorylation | SSNSRPSSIRSGSVS CCCCCCCCCCCCCCC | 25.38 | 22369663 | |
| 201 | Phosphorylation | SRPSSIRSGSVSRRK CCCCCCCCCCCCCCC | 33.48 | 22369663 | |
| 203 | Phosphorylation | PSSIRSGSVSRRKSD CCCCCCCCCCCCCCC | 20.40 | 23749301 | |
| 205 | Phosphorylation | SIRSGSVSRRKSDVT CCCCCCCCCCCCCCC | 28.23 | 22369663 | |
| 208 | Ubiquitination | SGSVSRRKSDVTHEE CCCCCCCCCCCCCCC | 50.31 | 17644757 | |
| 209 | Phosphorylation | GSVSRRKSDVTHEEP CCCCCCCCCCCCCCC | 35.19 | 19779198 | |
| 220 | Phosphorylation | HEEPNNGSYSSNNQE CCCCCCCCCCCCHHH | 24.78 | 28889911 | |
| 221 | Phosphorylation | EEPNNGSYSSNNQEN CCCCCCCCCCCHHHH | 19.95 | 23749301 | |
| 222 | Phosphorylation | EPNNGSYSSNNQENY CCCCCCCCCCHHHHH | 28.43 | 28889911 | |
| 223 | Phosphorylation | PNNGSYSSNNQENYL CCCCCCCCCHHHHHH | 31.41 | 23749301 | |
| 229 | Phosphorylation | SSNNQENYLVQALTR CCCHHHHHHHHHHHH | 13.90 | 23749301 | |
| 235 | Phosphorylation | NYLVQALTRSNSHAS HHHHHHHHHCCCCCH | 34.76 | 28889911 | |
| 237 | Phosphorylation | LVQALTRSNSHASSL HHHHHHHCCCCCHHH | 37.13 | 28889911 | |
| 239 | Phosphorylation | QALTRSNSHASSLHS HHHHHCCCCCHHHHC | 22.98 | 23749301 | |
| 242 | Phosphorylation | TRSNSHASSLHSRKS HHCCCCCHHHHCCCC | 28.19 | 30377154 | |
| 243 | Phosphorylation | RSNSHASSLHSRKSS HCCCCCHHHHCCCCC | 30.77 | 23749301 | |
| 246 | Phosphorylation | SHASSLHSRKSSFGS CCCHHHHCCCCCCCC | 46.85 | 28889911 | |
| 248 | Ubiquitination | ASSLHSRKSSFGSDG CHHHHCCCCCCCCCC | 54.16 | 23749301 | |
| 249 | Phosphorylation | SSLHSRKSSFGSDGN HHHHCCCCCCCCCCC | 29.77 | 17330950 | |
| 250 | Phosphorylation | SLHSRKSSFGSDGNT HHHCCCCCCCCCCCC | 36.34 | 17330950 | |
| 253 | Phosphorylation | SRKSSFGSDGNTAYS CCCCCCCCCCCCCCC | 40.09 | 17330950 | |
| 257 | Phosphorylation | SFGSDGNTAYSTPLN CCCCCCCCCCCCCCC | 32.28 | 17330950 | |
| 259 | Phosphorylation | GSDGNTAYSTPLNSP CCCCCCCCCCCCCCC | 15.84 | 22369663 | |
| 260 | Phosphorylation | SDGNTAYSTPLNSPG CCCCCCCCCCCCCCC | 22.53 | 22369663 | |
| 261 | Phosphorylation | DGNTAYSTPLNSPGL CCCCCCCCCCCCCCH | 21.08 | 22369663 | |
| 265 | Phosphorylation | AYSTPLNSPGLSKLT CCCCCCCCCCHHHCC | 28.20 | 22369663 | |
| 269 | Phosphorylation | PLNSPGLSKLTDHSG CCCCCCHHHCCCCCC | 31.38 | 22369663 | |
| 270 | Ubiquitination | LNSPGLSKLTDHSGE CCCCCHHHCCCCCCC | 61.52 | 17644757 | |
| 275 | Phosphorylation | LSKLTDHSGEYFTSN HHHCCCCCCCEECCC | 35.81 | 19779198 | |
| 278 | Phosphorylation | LTDHSGEYFTSNSTS CCCCCCCEECCCCCC | 18.71 | 23749301 | |
| 280 | Phosphorylation | DHSGEYFTSNSTSSL CCCCCEECCCCCCCC | 26.54 | 22369663 | |
| 281 | Phosphorylation | HSGEYFTSNSTSSLN CCCCEECCCCCCCCC | 20.91 | 22369663 | |
| 283 | Phosphorylation | GEYFTSNSTSSLNHH CCEECCCCCCCCCCC | 29.45 | 22369663 | |
| 284 | Phosphorylation | EYFTSNSTSSLNHHS CEECCCCCCCCCCCC | 26.95 | 22369663 | |
| 285 | Phosphorylation | YFTSNSTSSLNHHSS EECCCCCCCCCCCCC | 32.42 | 22369663 | |
| 286 | Phosphorylation | FTSNSTSSLNHHSSR ECCCCCCCCCCCCCC | 33.02 | 22369663 | |
| 291 | Phosphorylation | TSSLNHHSSRDIYPS CCCCCCCCCCCCCCC | 21.37 | 22369663 | |
| 292 | Phosphorylation | SSLNHHSSRDIYPSK CCCCCCCCCCCCCCC | 29.61 | 22369663 | |
| 298 | Phosphorylation | SSRDIYPSKHISNDD CCCCCCCCCCCCCCH | 21.64 | 21440633 | |
| 310 | Phosphorylation | NDDDIENSSQLSNIH CCHHCCCCHHHHHHH | 13.48 | 29136822 | |
| 311 | Phosphorylation | DDDIENSSQLSNIHA CHHCCCCHHHHHHHH | 46.88 | 20377248 | |
| 314 | Phosphorylation | IENSSQLSNIHASME CCCCHHHHHHHHHHH | 26.54 | 20377248 | |
| 319 | Phosphorylation | QLSNIHASMENVNDK HHHHHHHHHHHCCCC | 16.68 | 20377248 | |
| 326 | Ubiquitination | SMENVNDKNNNITDS HHHHCCCCCCCCCCC | 57.27 | 17644757 | |
| 331 | Phosphorylation | NDKNNNITDSKKDPN CCCCCCCCCCCCCCC | 36.02 | 23749301 | |
| 333 | Phosphorylation | KNNNITDSKKDPNEE CCCCCCCCCCCCCHH | 32.71 | 29136822 | |
| 334 | Ubiquitination | NNNITDSKKDPNEEF CCCCCCCCCCCCHHH | 65.10 | 17644757 | |
| 335 | Ubiquitination | NNITDSKKDPNEEFN CCCCCCCCCCCHHHH | 80.51 | 17644757 | |
| 351 | Ubiquitination | IMQSSGNKNAPKKFK HHHHCCCCCCCHHHC | 58.99 | 17644757 | |
| 358 | Ubiquitination | KNAPKKFKKPIDIDE CCCCHHHCCCCCHHH | 67.53 | 17644757 | |
| 359 | Ubiquitination | NAPKKFKKPIDIDET CCCHHHCCCCCHHHH | 50.79 | 17644757 | |
| 369 | Ubiquitination | DIDETIQKLLDAGYA CHHHHHHHHHHHHHH | 47.36 | 17644757 | |
| 378 | Ubiquitination | LDAGYAAKRTKNVCL HHHHHHHHHCCCEEC | 53.05 | 23749301 | |
| 415 | Ubiquitination | LELSPPVKIVGDVHG HHCCCCEEEEECCCC | 37.13 | 17644757 | |
| 468 | Acetylation | LLFCYKIKYPENFFL HHHHHHCCCCCCEEE | 51.07 | 24489116 | |
| 468 | Ubiquitination | LLFCYKIKYPENFFL HHHHHHCCCCCCEEE | 51.07 | 23749301 | |
| 505 | Ubiquitination | RCNIKIWKTFIDTFN HCCCEEEHHHHHHCC | 36.71 | 17644757 | |
| 523 | Ubiquitination | LAAIVAGKIFCVHGG HHHHHHCCEEEECCC | 23.91 | 17644757 | |
| 532 | Phosphorylation | FCVHGGLSPVLNSMD EEECCCCHHHHCCHH | 19.08 | 23749301 | |
| 593 | Ubiquitination | AINKFLNKFGFDLVC HHHHHHHHHCCCCEE | 49.35 | 23749301 | |
| 682 | Phosphorylation | QQQQMMETSITNDNE HHHHHHHHHCCCCCC | 13.92 | 22890988 | |
| 683 | Phosphorylation | QQQMMETSITNDNES HHHHHHHHCCCCCCC | 17.70 | 22890988 | |
| 685 | Phosphorylation | QMMETSITNDNESQQ HHHHHHCCCCCCCCC | 35.97 | 22890988 | |
| 690 | Phosphorylation | SITNDNESQQ----- HCCCCCCCCC----- | 39.89 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PPZ1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PPZ1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PPZ1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-171; THR-261 ANDSER-265, AND MASS SPECTROMETRY. | |
