TRK2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRK2_YEAST
• UniProt AC: P28584
• Protein Name: Low-affinity potassium transport protein
• Gene Name: TRK2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 889
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: This protein is required for low-affinity potassium transport..
• Protein Sequence: MPTAKRTSSRASLALPFQLRLVHKKSWGHRLRDFISGFLKSCRPIAKYVFPNFIVVHYIYLITLSIIGSILLYPCKNTAFIDVLFLAAGASTQGGLATKSTNDFNLYQQIVVYVITLLSTPILIHGFLAFVRLYWFERYFDNIRDISKQNFKLRRTMTLQQRELSGSSGNAARSRSFKDNLFRGKFVSREDPRQSASDVPMDSPDTSALSSISPLNVSSSKEESSDTQSSPPNFSSKRQPSDVDPRDIYKSIMMLQKQQEKSNANSTDSFSSETNGPAFIVQERHERRAPHCSLKRHSVLPSSQELNKLAQTKSFQKLLGLRRDEGDHDYFDGAPHKYMVTKKKKISRTQSCNIPTYTASPSPKTSGQVVENHRNLAKSAPSSFVDEEMSFSPQESLNLQFQAHPPKPKRREGDIGHPFTRTMSTNYLSWQPTFGRNSVFIGLTKQQKEELGGVEYRALRLLCCILMVYYIGFNILAFVTIVPWACTRHHYSEIIRRNGVSPTWWGFFTAMSAFSNLGLSLTADSMVSFDTAPYPLIFMMFFIIIGNTGFPIMLRFIIWIMFKTSRDLSQFKESLGFLLDHPRRCFTLLFPSGPTWWLFTTLVVLNATDWILFIILDFNSAVVRQVAKGYRALMGLFQSVCTRTAGFNVVDLSKLHPSIQVSYMLMMYVSVLPLAISIRRTNVYEEQSLGLYDSGQDDENITHEDDIKETDHDGESEERDTVSTKSKPKKQSPKSFVGAHLRRQLSFDLWYLFLGLFIICICEGRKIEDVNKPDFNVFAILFEVVSAYGTVGLSLGYPNTNTSLSAQFTVLSKLVIIAMLIRGRNRGLPYTLDRAIMLPSDKLEQIDRLQDMKAKGKLLAKVGEDPMTTYVKKRSHKLKKIATKFWGKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
216	N-linked_Glycosylation	LSSISPLNVSSSKEE HHCCCCCCCCCCCCC	34.70	-
233	N-linked_Glycosylation	DTQSSPPNFSSKRQP CCCCCCCCCCCCCCC	53.46	-
235	Phosphorylation	QSSPPNFSSKRQPSD CCCCCCCCCCCCCCC	41.40	24930733
236	Phosphorylation	SSPPNFSSKRQPSDV CCCCCCCCCCCCCCC	27.93	25371407
265	N-linked_Glycosylation	QQEKSNANSTDSFSS HHHHHCCCCCCCCCC	50.09	-
870	Phosphorylation	GEDPMTTYVKKRSHK CCCCCHHHHHHCHHH	10.91	28132839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRK2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRK2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRK2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PTK1_YEAST	PTK1	genetic	12135613
PTK2_YEAST	PTK2	genetic	12135613
SKY1_YEAST	SKY1	genetic	12135613
BAP2_YEAST	BAP2	genetic	9153214
TOK1_YEAST	TOK1	genetic	10089235
TRK1_YEAST	TRK1	genetic	2199312
HXT1_YEAST	HXT1	genetic	8417358
HXT3_YEAST	HXT3	genetic	8417358
GAL2_YEAST	GAL2	genetic	9447989
HXT1_YEAST	HXT1	genetic	9447989
HXT3_YEAST	HXT3	genetic	9447989
TOK1_YEAST	TOK1	genetic	12135613
TRK1_YEAST	TRK1	genetic	8282703
TRK1_YEAST	TRK1	genetic	18408719
SIN3_YEAST	SIN3	genetic	7892273
TRK1_YEAST	TRK1	genetic	15642368
SIS2_YEAST	SIS2	genetic	11867520
PPZ2_YEAST	PPZ2	genetic	11867520
PPZ1_YEAST	PPZ1	genetic	11867520
PMP3_YEAST	PMP3	genetic	10835350
TOK1_YEAST	TOK1	genetic	22329368
NAH1_YEAST	NHA1	genetic	22329368
BMH1_YEAST	BMH1	genetic	22484491
VNX1_YEAST	VNX1	genetic	23022132
VHC1_YEAST	VHC1	genetic	23022132
YJ24_YEAST	KCH1	genetic	23204190
PRM6_YEAST	PRM6	genetic	23204190
FLO8_YEAST	FLO8	genetic	23454581
SIS2_YEAST	SIS2	genetic	23454581
YJ24_YEAST	KCH1	genetic	28810704
PRM6_YEAST	PRM6	genetic	28810704

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.