| UniProt ID | VHC1_YEAST | |
|---|---|---|
| UniProt AC | P38329 | |
| Protein Name | Vacuolar cation-chloride cotransporter 1 {ECO:0000305|PubMed:23022132} | |
| Gene Name | VHC1 {ECO:0000303|PubMed:23022132} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1120 | |
| Subcellular Localization |
Vacuole membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the coordinated symport of chloride with potassium ions across the vacuolar membrane. Involved in vacuolar osmoregulation.. | |
| Protein Sequence | MVSRFYQIPGTHRPSSAISSSNESSSLLSARRISQTYFNYQATPECQKVSSKYDPDNPNKDKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNGTVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEPPAALGELLPRGHWHEFTYATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFSIPLSALIRSPFTEGGISYTGPSWQTFHDNLLPHLTKGAAGSLLKGKETFNDLFGVFFPATAGIFAGAGMSSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEVQIIQTISSVQWVIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHSPLYSLIFTWILTQLCLFSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAMLIVDGISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLRQDNIKYWRPQILLFVDNPRTSWNLIRFCNHLKKGGLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAAIKAFVQVGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNLQKQVEIKATVPRSTCSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKNLEIPNKRDSCFPKKTIDLYPIQMCGKVEAKGDQPAAITTNFDTYTLILQLAAILVTVPEWKRTHSLRVILFVEQEYHRTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVFDYVNSKLADNEWWKDLVEARDTLKPKRRFSTIEPQTIAKQFTQSRKYTSGVQKLGVSFTMNTRMPTNRIDTPCESEDSDLDTDLTSIRDAFSASTNISVGKDLTTKSKTGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDGTGEQPTLIPIAEPDLSNGNGTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQHLVLNDVMTQMSKSSDLIFSTLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTTAL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | IPGTHRPSSAISSSN CCCCCCCCCCCCCCC | 19779198 | ||
| 16 | Phosphorylation | PGTHRPSSAISSSNE CCCCCCCCCCCCCCC | 19779198 | ||
| 19 | Phosphorylation | HRPSSAISSSNESSS CCCCCCCCCCCCCHH | 19779198 | ||
| 21 | Phosphorylation | PSSAISSSNESSSLL CCCCCCCCCCCHHHH | 19779198 | ||
| 24 | Phosphorylation | AISSSNESSSLLSAR CCCCCCCCHHHHHHH | 19684113 | ||
| 25 | Phosphorylation | ISSSNESSSLLSARR CCCCCCCHHHHHHHH | 19684113 | ||
| 26 | Phosphorylation | SSSNESSSLLSARRI CCCCCCHHHHHHHHE | 19684113 | ||
| 29 | Phosphorylation | NESSSLLSARRISQT CCCHHHHHHHHEECH | 19684113 | ||
| 34 | Phosphorylation | LLSARRISQTYFNYQ HHHHHHEECHHHCCC | 22369663 | ||
| 36 | Phosphorylation | SARRISQTYFNYQAT HHHHEECHHHCCCCC | 22369663 | ||
| 37 | Phosphorylation | ARRISQTYFNYQATP HHHEECHHHCCCCCH | 22369663 | ||
| 40 | Phosphorylation | ISQTYFNYQATPECQ EECHHHCCCCCHHHH | 22369663 | ||
| 43 | Phosphorylation | TYFNYQATPECQKVS HHHCCCCCHHHHHCC | 23749301 | ||
| 131 | Phosphorylation | TVRGGGAYYMISRSL CCCCCCEEEEEECCC | 28889911 | ||
| 314 | Phosphorylation | ELRKPSKSIPKGTLW HHCCCCCCCCCCHHH | 28889911 | ||
| 587 | Ubiquitination | PKQLNELKTQQKAWM HHHHHHHHHHHHHHH | 23749301 | ||
| 652 | Phosphorylation | YRKHIPQSRSQNNLQ HHHHCCCCCCCCCHH | 21440633 | ||
| 654 | Phosphorylation | KHIPQSRSQNNLQKQ HHCCCCCCCCCHHHH | 17287358 | ||
| 660 | Ubiquitination | RSQNNLQKQVEIKAT CCCCCHHHHEEEEEE | 23749301 | ||
| 671 | Phosphorylation | IKATVPRSTCSDVKI EEEECCCCCCCCEEE | 21551504 | ||
| 672 | Phosphorylation | KATVPRSTCSDVKIN EEECCCCCCCCEEEE | 27717283 | ||
| 674 | Phosphorylation | TVPRSTCSDVKINVP ECCCCCCCCEEEECC | 21440633 | ||
| 829 | Phosphorylation | SLDQFRVYNTIVKGD EHHHHEEECEEECCC | 28889911 | ||
| 831 | Phosphorylation | DQFRVYNTIVKGDPI HHHEEECEEECCCCE | 28889911 | ||
| 846 | Ubiquitination | VFDYVNSKLADNEWW EEEECCCCCCCCHHH | 19722269 | ||
| 870 | Phosphorylation | LKPKRRFSTIEPQTI CCCCCCCCCCCHHHH | 17330950 | ||
| 871 | Phosphorylation | KPKRRFSTIEPQTIA CCCCCCCCCCHHHHH | 29136822 | ||
| 888 | Phosphorylation | FTQSRKYTSGVQKLG HHHCCCCCCCCCCCC | 27017623 | ||
| 889 | Phosphorylation | TQSRKYTSGVQKLGV HHCCCCCCCCCCCCE | 27017623 | ||
| 897 | Phosphorylation | GVQKLGVSFTMNTRM CCCCCCEEEEECCCC | 28889911 | ||
| 902 | Phosphorylation | GVSFTMNTRMPTNRI CEEEEECCCCCCCCC | 27017623 | ||
| 911 | Phosphorylation | MPTNRIDTPCESEDS CCCCCCCCCCCCCCC | 23749301 | ||
| 915 | Phosphorylation | RIDTPCESEDSDLDT CCCCCCCCCCCCCCC | 19684113 | ||
| 918 | Phosphorylation | TPCESEDSDLDTDLT CCCCCCCCCCCCCCH | 19684113 | ||
| 922 | Phosphorylation | SEDSDLDTDLTSIRD CCCCCCCCCCHHHHH | 28889911 | ||
| 938 | Phosphorylation | FSASTNISVGKDLTT HHHCCCEECCCCCCC | 27214570 | ||
| 966 | Phosphorylation | KNLQSDVSTQSLRPV HHHCCCCCCCCCCCC | 19779198 | ||
| 967 | Phosphorylation | NLQSDVSTQSLRPVF HHCCCCCCCCCCCCC | 19779198 | ||
| 975 | Phosphorylation | QSLRPVFSSNTLPRT CCCCCCCCCCCCCCE | 23749301 | ||
| 978 | Phosphorylation | RPVFSSNTLPRTRVV CCCCCCCCCCCEEEE | 23749301 | ||
| 1028 | Phosphorylation | KPVLPELSPCCSKDS CCCCCCCCCCCCHHH | 29136822 | ||
| 1032 | Phosphorylation | PELSPCCSKDSLVTA CCCCCCCCHHHHHHH | 29136822 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VHC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VHC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VHC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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