| UniProt ID | ERG3_YEAST | |
|---|---|---|
| UniProt AC | P32353 | |
| Protein Name | Delta(7)-sterol 5(6)-desaturase | |
| Gene Name | ERG3 {ECO:0000303|PubMed:1864507} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 365 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.. | |
| Protein Sequence | MDLVLEVADHYVLDDLYAKVLPASLAANIPVKWQKLLGLNSGFSNSTILQETLNSKNAVKECRRFYGQVPFLFDMSTTSFASLLPRSSILREFLSLWVIVTIFGLLLYLFTASLSYVFVFDKSIFNHPRYLKNQMAMEIKLAVSAIPWMSMLTVPWFVMELNGHSKLYMKIDYENHGVRKLIIEYFTFIFFTDCGVYLAHRWLHWPRVYRALHKPHHKWLVCTPFASHSFHPVDGFLQSISYHIYPLILPLHKVSYLILFTFVNFWTVMIHDGQYLSNNPAVNGTACHTVHHLYFNYNYGQFTTLWDRLGGSYRRPDDSLFDPKLRDAKETWDAQVKEVEHFIKEVEGDDNDRIYENDPNTKKNN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Ubiquitination | VLDDLYAKVLPASLA HHHHHHHHHHCHHHH | 30.65 | 17644757 | |
| 32 | Ubiquitination | LAANIPVKWQKLLGL HHHCCCCCHHHHHCC | 38.25 | 17644757 | |
| 32 | Acetylation | LAANIPVKWQKLLGL HHHCCCCCHHHHHCC | 38.25 | 24489116 | |
| 35 | Ubiquitination | NIPVKWQKLLGLNSG CCCCCHHHHHCCCCC | 44.56 | 17644757 | |
| 56 | Ubiquitination | LQETLNSKNAVKECR HHHHHCCCHHHHHHH | 48.10 | 23749301 | |
| 60 | Ubiquitination | LNSKNAVKECRRFYG HCCCHHHHHHHHHHC | 49.00 | 22817900 | |
| 324 | Ubiquitination | DDSLFDPKLRDAKET CCCCCCHHHHCHHHH | 58.98 | 22817900 | |
| 324 | Acetylation | DDSLFDPKLRDAKET CCCCCCHHHHCHHHH | 58.98 | 24489116 | |
| 329 | Ubiquitination | DPKLRDAKETWDAQV CHHHHCHHHHHHHHH | 61.02 | 23749301 | |
| 337 | Ubiquitination | ETWDAQVKEVEHFIK HHHHHHHHHHHHHHH | 43.92 | 17644757 | |
| 337 | Acetylation | ETWDAQVKEVEHFIK HHHHHHHHHHHHHHH | 43.92 | 24489116 | |
| 344 | Ubiquitination | KEVEHFIKEVEGDDN HHHHHHHHHHHCCCC | 55.55 | 24961812 | |
| 344 | Acetylation | KEVEHFIKEVEGDDN HHHHHHHHHHHCCCC | 55.55 | 24489116 | |
| 362 | Ubiquitination | YENDPNTKKNN---- CCCCCCCCCCC---- | 61.21 | 17644757 | |
| 363 | Ubiquitination | ENDPNTKKNN----- CCCCCCCCCC----- | 60.73 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERG3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERG3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERG3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Ubiquitylation | |
| Reference | PubMed |
| "A proteomics approach to understanding protein ubiquitination."; Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.; Nat. Biotechnol. 21:921-926(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-324 AND LYS-344, AND MASSSPECTROMETRY. | |
