| UniProt ID | HAL5_YEAST | |
|---|---|---|
| UniProt AC | P38970 | |
| Protein Name | Serine/threonine-protein kinase HAL5 | |
| Gene Name | HAL5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 855 | |
| Subcellular Localization | ||
| Protein Description | Protein kinase involved in salt tolerance and pH sensitivity, probably by regulating plasma membrane potential and cation influx. Positively controls the TRK1-TRK2 potassium transport system in response to potassium starvation. Stabilizes TRK1 in the plasma membrane by preventing its vacuolar sorting and degradation. Also stabilizes other plasma membrane nutrient transporters like CAN1, FUR4 and HXT1. May itself be subject to regulation by ARL1.. | |
| Protein Sequence | MGDEKLSRHTSLKRARSLSESIKGLFKPSGISGSNNAAAPSSRPGQDQAHSHQTARIITSNVSSPSISPVHSPVLQAAPKHHKLGVPNIAKLSLSPSREPSLNSENEMFSQESFISEKDEDEANLLEREDLQNKKEEKARAKHVRSKEAYVPHHRYTVGSDEVERQPRERLKNFPQNAGSSNPANSNANHVLDQENNFSIDAMLDYDEESKLRRRNSLGVRNHSNRTRSRKNSLSTPRSPPMKNGNGGMNSNATNNVGNGTGNRIYMRGRNHSDSISASSLPKFQEIECKCILDLGHFKVFENGYHEHSLRVLPIITNNKNVDSGDEKDADASVNSGDDGDNDSEANMHKQKSVFSLSGLFKSHKDGNQQQQQQQQQEENGEQINLEKAFSIIPSQRFIKSQTLKKSRTSNLKNGNNDELMKNDGKNIPQIVNPNAAVGVEELKLINALSEKIRKGLKSENTKGNNGEGRSNSNKQEDSDDTEGKAGTTNDDTSHKPCSQKYGKSIGVVGAGAYGVVKICARCKTAKDVLPYSTYSNGKKLFFAVKELKPKPGDQIDKFCTRLTSEFIIGHSLSHPHFEANAMIAGNVSRTTPPKHVFNAPNILKILDLMEYSNSFVEVMEFCASGDLYSLLTRNNISNESNNGSSRLIQTVKEGSGSPLHPLEADCFMKQLLNGVQYMHDHGIAHCDLKPENILFQPNGLLKICDFGTSSVFQTAWEKHVHFQSGAMGSEPYVAPEEFIRDAEYDPRLVDCWSCGIVYCTMVMGQYLWKIAIPEKDSLFKSFLSEIKDDGQFYLFEELRHVSSELNRLRKIALYRTFQVDPTKRITIEQLLQSSWMRKTKCCVVYRHLHTKVSK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MGDEKLSRHTSLKR -CCHHHHHHHHHHHH | 32.84 | 17287358 | |
| 10 | Phosphorylation | DEKLSRHTSLKRARS HHHHHHHHHHHHHHH | 34.34 | 17287358 | |
| 11 | Phosphorylation | EKLSRHTSLKRARSL HHHHHHHHHHHHHHH | 26.26 | 19823750 | |
| 17 | Phosphorylation | TSLKRARSLSESIKG HHHHHHHHHHHHHHH | 34.95 | 19823750 | |
| 19 | Phosphorylation | LKRARSLSESIKGLF HHHHHHHHHHHHHHH | 30.46 | 19823750 | |
| 21 | Phosphorylation | RARSLSESIKGLFKP HHHHHHHHHHHHHCC | 26.65 | 19795423 | |
| 23 | Acetylation | RSLSESIKGLFKPSG HHHHHHHHHHHCCCC | 59.86 | 22865919 | |
| 59 | Phosphorylation | HQTARIITSNVSSPS CCCEEEHHCCCCCCC | 16.33 | 28889911 | |
| 60 | Phosphorylation | QTARIITSNVSSPSI CCEEEHHCCCCCCCC | 25.48 | 22369663 | |
| 63 | Phosphorylation | RIITSNVSSPSISPV EEHHCCCCCCCCCCC | 40.56 | 22369663 | |
| 64 | Phosphorylation | IITSNVSSPSISPVH EHHCCCCCCCCCCCC | 20.55 | 22369663 | |
| 66 | Phosphorylation | TSNVSSPSISPVHSP HCCCCCCCCCCCCCH | 37.33 | 24909858 | |
| 68 | Phosphorylation | NVSSPSISPVHSPVL CCCCCCCCCCCCHHH | 25.80 | 22369663 | |
| 72 | Phosphorylation | PSISPVHSPVLQAAP CCCCCCCCHHHHHCC | 19.55 | 17330950 | |
| 95 | Phosphorylation | NIAKLSLSPSREPSL CCEEECCCCCCCCCC | 19.90 | 28889911 | |
| 116 | Phosphorylation | FSQESFISEKDEDEA CCHHHHHCCCCHHHH | 36.26 | 28889911 | |
| 156 | Phosphorylation | AYVPHHRYTVGSDEV CCCCCCCCCCCCHHH | 11.04 | 24961812 | |
| 157 | Phosphorylation | YVPHHRYTVGSDEVE CCCCCCCCCCCHHHH | 20.53 | 17330950 | |
| 160 | Phosphorylation | HHRYTVGSDEVERQP CCCCCCCCHHHHCCH | 26.68 | 28889911 | |
| 217 | Phosphorylation | SKLRRRNSLGVRNHS HHHHHHHCCCCCCCC | 25.37 | 25533186 | |
| 229 | Phosphorylation | NHSNRTRSRKNSLST CCCCCCCCCCCCCCC | 47.17 | 24930733 | |
| 233 | Phosphorylation | RTRSRKNSLSTPRSP CCCCCCCCCCCCCCC | 27.08 | 25533186 | |
| 235 | Phosphorylation | RSRKNSLSTPRSPPM CCCCCCCCCCCCCCC | 35.87 | 25005228 | |
| 236 | Phosphorylation | SRKNSLSTPRSPPMK CCCCCCCCCCCCCCC | 28.19 | 21551504 | |
| 239 | Phosphorylation | NSLSTPRSPPMKNGN CCCCCCCCCCCCCCC | 34.26 | 28889911 | |
| 254 | Phosphorylation | GGMNSNATNNVGNGT CCCCCCCCCCCCCCC | 31.41 | 21440633 | |
| 261 | Phosphorylation | TNNVGNGTGNRIYMR CCCCCCCCCCCEEEC | 34.97 | 27017623 | |
| 273 | Phosphorylation | YMRGRNHSDSISASS EECCCCCCCCCCHHH | 36.28 | 22369663 | |
| 275 | Phosphorylation | RGRNHSDSISASSLP CCCCCCCCCCHHHCC | 22.81 | 22369663 | |
| 277 | Phosphorylation | RNHSDSISASSLPKF CCCCCCCCHHHCCCC | 26.50 | 22369663 | |
| 279 | Phosphorylation | HSDSISASSLPKFQE CCCCCCHHHCCCCCE | 26.14 | 22890988 | |
| 280 | Phosphorylation | SDSISASSLPKFQEI CCCCCHHHCCCCCEE | 48.70 | 22369663 | |
| 324 | Phosphorylation | TNNKNVDSGDEKDAD ECCCCCCCCCCCCCC | 43.81 | 21082442 | |
| 333 | Phosphorylation | DEKDADASVNSGDDG CCCCCCCCCCCCCCC | 23.52 | 22890988 | |
| 336 | Phosphorylation | DADASVNSGDDGDND CCCCCCCCCCCCCCC | 41.25 | 22369663 | |
| 344 | Phosphorylation | GDDGDNDSEANMHKQ CCCCCCCHHHHHHHH | 44.88 | 22890988 | |
| 353 | Phosphorylation | ANMHKQKSVFSLSGL HHHHHHHHHHHHHHH | 26.38 | 22890988 | |
| 356 | Phosphorylation | HKQKSVFSLSGLFKS HHHHHHHHHHHHHHH | 21.33 | 22890988 | |
| 358 | Phosphorylation | QKSVFSLSGLFKSHK HHHHHHHHHHHHHCC | 32.05 | 22369663 | |
| 391 | Phosphorylation | INLEKAFSIIPSQRF CCHHHHHHHCCCHHH | 25.19 | 22369663 | |
| 395 | Phosphorylation | KAFSIIPSQRFIKSQ HHHHHCCCHHHHHHH | 24.47 | 22369663 | |
| 409 | Phosphorylation | QTLKKSRTSNLKNGN HCCCCCCCCCCCCCC | 29.11 | 28889911 | |
| 410 | Phosphorylation | TLKKSRTSNLKNGNN CCCCCCCCCCCCCCC | 38.77 | 19779198 | |
| 450 | Phosphorylation | LKLINALSEKIRKGL HHHHHHHHHHHHHHH | 34.14 | 28132839 | |
| 452 | Acetylation | LINALSEKIRKGLKS HHHHHHHHHHHHHCC | 44.42 | 24489116 | |
| 471 | Phosphorylation | GNNGEGRSNSNKQED CCCCCCCCCCCCCCC | 56.31 | 27214570 | |
| 473 | Phosphorylation | NGEGRSNSNKQEDSD CCCCCCCCCCCCCCC | 46.80 | 28889911 | |
| 479 | Phosphorylation | NSNKQEDSDDTEGKA CCCCCCCCCCCCCCC | 36.31 | 28889911 | |
| 482 | Phosphorylation | KQEDSDDTEGKAGTT CCCCCCCCCCCCCCC | 52.18 | 27717283 | |
| 638 | Phosphorylation | LLTRNNISNESNNGS HHHHCCCCCCCCCCC | 36.35 | 30377154 | |
| 641 | Phosphorylation | RNNISNESNNGSSRL HCCCCCCCCCCCCCC | 39.59 | 28889911 | |
| 645 | Phosphorylation | SNESNNGSSRLIQTV CCCCCCCCCCCEEEC | 17.89 | 28889911 | |
| 646 | Phosphorylation | NESNNGSSRLIQTVK CCCCCCCCCCEEECC | 32.29 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HAL5_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HAL5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HAL5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63; SER-68; SER-72;SER-160; SER-233; SER-273; SER-280; SER-324; SER-336; SER-391 ANDSER-395, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-19; SER-217;SER-233 AND SER-273, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; THR-10; SER-17 ANDSER-19, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68; SER-72; SER-358;SER-391 AND SER-395, AND MASS SPECTROMETRY. | |
