ACA1_YEAST - dbPTM
ACA1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ACA1_YEAST
UniProt AC P39970
Protein Name ATF/CREB activator 1
Gene Name ACA1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 489
Subcellular Localization Nucleus .
Protein Description Transcriptional activator of promoters containing ATF/CREB sites. Can independently stimulate transcription through ATF/CREB sites. Important for a variety of biological functions including growth on non-optimal carbon sources. Regulates the expression of COS8. Has efficient silencing blocking activities..
Protein Sequence MDYKHNFATSPDSFLDGRQNPLLYTDFLSSNKELIYKQPSGPGLVDSAYNFHHQNSLHDRSVQENLGPMFQPFGVDISHLPITNPPIFQSSLPAFDQPVYKRRISISNGQISQLGEDLETVENLYNCQPPILSSKAQQNPNPQQVANPSAAIYPSFSSNELQNVPQPHEQATVIPEAAPQTGSKNIYAAMTPYDSNIKLNIPAVAATCDIPSATPSIPSGDSTMNQAYINMQLRLQAQMQTKAWKNAQLNVHPCTPASNSSVSSSSSCQNINDHNIENQSVHSSISHGVNHHTVNNSCQNAELNISSSLPYESKCPDVNLTHANSKPQYKDATSALKNNINSEKDVHTAPFSSMHTTATFQIKQEARPQKIENNTAGLKDGAKAWKRARLLERNRIAASKCRQRKKMSQLQLQREFDQISKENTMMKKKIENYEKLVQKMKKISRLHMQECTINGGNNSYQSLQNKDSDVNGFLKMIEEMIRSSSLYDE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationRQNPLLYTDFLSSNK
CCCCCHHHCCHHCCC		21.9028889911
29PhosphorylationLLYTDFLSSNKELIY
CHHHCCHHCCCEEEE		31.6828889911
105PhosphorylationPVYKRRISISNGQIS
CCEEEEEEECCCCHH		20.3921440633
191PhosphorylationKNIYAAMTPYDSNIK
CCEEEEECCCCCCCC		17.6124961812
193PhosphorylationIYAAMTPYDSNIKLN
EEEEECCCCCCCCCC		23.8824961812
195PhosphorylationAAMTPYDSNIKLNIP
EEECCCCCCCCCCCC		34.3124961812
375PhosphorylationPQKIENNTAGLKDGA
CCCCCCCCCCCHHHH		33.4129734811
400AcetylationRNRIAASKCRQRKKM
HHHHHHHHHHHHHHH		28.8025381059
444PhosphorylationVQKMKKISRLHMQEC
HHHHHHHHHHHCEEE		37.3529136822
459PhosphorylationTINGGNNSYQSLQNK
EEECCCCCCHHHHCC		28.6629136822
460PhosphorylationINGGNNSYQSLQNKD
EECCCCCCHHHHCCC		12.3029136822
462PhosphorylationGGNNSYQSLQNKDSD
CCCCCCHHHHCCCCC		24.5629136822
483PhosphorylationMIEEMIRSSSLYDE-
HHHHHHHHCCCCCC-		17.2228889911
484PhosphorylationIEEMIRSSSLYDE--
HHHHHHHCCCCCC--		17.9528889911
485PhosphorylationEEMIRSSSLYDE---
HHHHHHCCCCCC---		31.9928889911
487PhosphorylationMIRSSSLYDE-----
HHHHCCCCCC-----		21.7028889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ACA1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ACA1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ACA1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RGT1_YEASTRGT1genetic
20959818
URE2_YEASTURE2genetic
20959818
EAF5_YEASTEAF5genetic
20959818
SIN3_YEASTSIN3genetic
20959818
DOA1_YEASTDOA1genetic
20959818
BAS1_YEASTBAS1genetic
20959818
UBP3_YEASTUBP3genetic
20959818
REI1_YEASTREI1genetic
21127252
SPC72_YEASTSPC72physical
22875988
ARE1_YEASTARE1physical
22875988
ACA1_YEASTACA1physical
22875988
SPR3_YEASTSPR3physical
22875988
HOS4_YEASTHOS4physical
22875988
SGM1_YEASTSGM1physical
22875988
RNA1_YEASTRNA1physical
22875988
NST1_YEASTNST1physical
22875988
BNI1_YEASTBNI1physical
22875988
RLF2_YEASTRLF2physical
22875988
BUD31_YEASTBUD31genetic
27708008
ELP2_YEASTELP2genetic
27708008
YHA8_YEASTYHL008Cgenetic
27708008
GSH1_YEASTGSH1genetic
27708008
SRL3_YEASTSRL3genetic
27708008
METK1_YEASTSAM1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ACA1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, AND MASSSPECTROMETRY.

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