| UniProt ID | METK1_YEAST | |
|---|---|---|
| UniProt AC | P10659 | |
| Protein Name | S-adenosylmethionine synthase 1 | |
| Gene Name | SAM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 382 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.. | |
| Protein Sequence | MAGTFLFTSESVGEGHPDKICDQVSDAILDACLAEDPHSKVACETAAKTGMIMVFGEITTKAQLDYQKIVRDTIKKIGYDDSAKGFDYKTCNVLVAIEQQSPDIAQGVHEEKDLEDIGAGDQGIMFGYATDETPEGLPLTILLAHKLNMAMADARRDGSLAWLRPDTKTQVTVEYKDDHGRWVPQRIDTVVVSAQHADEITTEDLRAQLKSEIIEKVIPRDMLDENTKYFIQPSGRFVIGGPQGDAGLTGRKIIVDAYGGASSVGGGAFSGKDYSKVDRSAAYAARWVAKSLVAAGLCKRVQVQFSYAIGIAEPLSLHVDTYGTATKSDEEIIDIISKNFDLRPGVLVKELDLARPIYLPTASYGHFTNQEYPWEKPKTLKF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MAGTFLFTSES ----CCCEEEEEECC | 13.97 | 22369663 | |
| 19 | Ubiquitination | VGEGHPDKICDQVSD CCCCCCHHHHHHHHH | 50.08 | 15699485 | |
| 25 | Phosphorylation | DKICDQVSDAILDAC HHHHHHHHHHHHHHH | 18.72 | 27214570 | |
| 40 | Ubiquitination | LAEDPHSKVACETAA HCCCCCCCHHHHHHH | 30.71 | 24961812 | |
| 45 | Phosphorylation | HSKVACETAAKTGMI CCCHHHHHHHHHCCE | 31.62 | 27214570 | |
| 48 | Ubiquitination | VACETAAKTGMIMVF HHHHHHHHHCCEEEE | 43.05 | 23749301 | |
| 61 | Ubiquitination | VFGEITTKAQLDYQK EEEEECCHHHHCHHH | 26.03 | 17644757 | |
| 68 | Acetylation | KAQLDYQKIVRDTIK HHHHCHHHHHHHHHH | 36.62 | 24489116 | |
| 68 | Ubiquitination | KAQLDYQKIVRDTIK HHHHCHHHHHHHHHH | 36.62 | 23749301 | |
| 73 | Phosphorylation | YQKIVRDTIKKIGYD HHHHHHHHHHHHCCC | 24.92 | 27017623 | |
| 75 | Ubiquitination | KIVRDTIKKIGYDDS HHHHHHHHHHCCCCC | 40.19 | 22817900 | |
| 76 | Ubiquitination | IVRDTIKKIGYDDSA HHHHHHHHHCCCCCC | 37.20 | 23749301 | |
| 82 | Phosphorylation | KKIGYDDSAKGFDYK HHHCCCCCCCCCCCC | 29.05 | 27214570 | |
| 84 | Succinylation | IGYDDSAKGFDYKTC HCCCCCCCCCCCCCC | 65.15 | 23954790 | |
| 84 | Ubiquitination | IGYDDSAKGFDYKTC HCCCCCCCCCCCCCC | 65.15 | 23749301 | |
| 84 | Acetylation | IGYDDSAKGFDYKTC HCCCCCCCCCCCCCC | 65.15 | 24489116 | |
| 89 | Acetylation | SAKGFDYKTCNVLVA CCCCCCCCCCEEEEE | 48.74 | 25381059 | |
| 89 | Ubiquitination | SAKGFDYKTCNVLVA CCCCCCCCCCEEEEE | 48.74 | 22817900 | |
| 91 | Glutathionylation | KGFDYKTCNVLVAIE CCCCCCCCEEEEEEE | 2.65 | 22833525 | |
| 101 | Phosphorylation | LVAIEQQSPDIAQGV EEEEECCCCCHHHCC | 25.00 | 22369663 | |
| 146 | Ubiquitination | LTILLAHKLNMAMAD HHHHHHHHHCHHHHH | 35.63 | 17644757 | |
| 159 | Phosphorylation | ADARRDGSLAWLRPD HHHHCCCCEEEECCC | 21.14 | 21440633 | |
| 167 | Phosphorylation | LAWLRPDTKTQVTVE EEEECCCCCCEEEEE | 38.38 | 28132839 | |
| 168 | Ubiquitination | AWLRPDTKTQVTVEY EEECCCCCCEEEEEE | 44.32 | 24961812 | |
| 169 | Phosphorylation | WLRPDTKTQVTVEYK EECCCCCCEEEEEEE | 30.29 | 28889911 | |
| 172 | Phosphorylation | PDTKTQVTVEYKDDH CCCCCEEEEEEECCC | 9.59 | 28889911 | |
| 175 | Phosphorylation | KTQVTVEYKDDHGRW CCEEEEEEECCCCCC | 18.51 | 28132839 | |
| 176 | Acetylation | TQVTVEYKDDHGRWV CEEEEEEECCCCCCC | 43.08 | 24489116 | |
| 176 | Ubiquitination | TQVTVEYKDDHGRWV CEEEEEEECCCCCCC | 43.08 | 17644757 | |
| 210 | Ubiquitination | EDLRAQLKSEIIEKV HHHHHHHHHHHHHHH | 33.68 | 23749301 | |
| 210 | Acetylation | EDLRAQLKSEIIEKV HHHHHHHHHHHHHHH | 33.68 | 24489116 | |
| 210 | Succinylation | EDLRAQLKSEIIEKV HHHHHHHHHHHHHHH | 33.68 | 23954790 | |
| 211 | Phosphorylation | DLRAQLKSEIIEKVI HHHHHHHHHHHHHHC | 42.49 | 23749301 | |
| 216 | Acetylation | LKSEIIEKVIPRDML HHHHHHHHHCCHHHC | 34.75 | 24489116 | |
| 228 | Ubiquitination | DMLDENTKYFIQPSG HHCCCCCCEEECCCC | 50.15 | 23749301 | |
| 228 | Acetylation | DMLDENTKYFIQPSG HHCCCCCCEEECCCC | 50.15 | 24489116 | |
| 228 | Succinylation | DMLDENTKYFIQPSG HHCCCCCCEEECCCC | 50.15 | 23954790 | |
| 234 | Phosphorylation | TKYFIQPSGRFVIGG CCEEECCCCCEEECC | 26.65 | 22369663 | |
| 249 | Phosphorylation | PQGDAGLTGRKIIVD CCCCCCCCCCEEEEE | 33.74 | 27214570 | |
| 252 | Ubiquitination | DAGLTGRKIIVDAYG CCCCCCCEEEEECCC | 37.82 | 22817900 | |
| 258 | Phosphorylation | RKIIVDAYGGASSVG CEEEEECCCCCCCCC | 16.19 | 22369663 | |
| 262 | Phosphorylation | VDAYGGASSVGGGAF EECCCCCCCCCCCCC | 28.91 | 22369663 | |
| 263 | Phosphorylation | DAYGGASSVGGGAFS ECCCCCCCCCCCCCC | 25.01 | 22369663 | |
| 270 | Phosphorylation | SVGGGAFSGKDYSKV CCCCCCCCCCCCCCC | 44.38 | 22369663 | |
| 272 | Acetylation | GGGAFSGKDYSKVDR CCCCCCCCCCCCCCH | 52.90 | 24489116 | |
| 272 | Ubiquitination | GGGAFSGKDYSKVDR CCCCCCCCCCCCCCH | 52.90 | 23749301 | |
| 276 | Acetylation | FSGKDYSKVDRSAAY CCCCCCCCCCHHHHH | 41.76 | 24489116 | |
| 276 | Succinylation | FSGKDYSKVDRSAAY CCCCCCCCCCHHHHH | 41.76 | 23954790 | |
| 276 | Ubiquitination | FSGKDYSKVDRSAAY CCCCCCCCCCHHHHH | 41.76 | 22817900 | |
| 290 | Ubiquitination | YAARWVAKSLVAAGL HHHHHHHHHHHHHHH | 34.40 | 23749301 | |
| 290 | Acetylation | YAARWVAKSLVAAGL HHHHHHHHHHHHHHH | 34.40 | 24489116 | |
| 291 | Phosphorylation | AARWVAKSLVAAGLC HHHHHHHHHHHHHHC | 20.52 | 21440633 | |
| 299 | Succinylation | LVAAGLCKRVQVQFS HHHHHHCCEEEEEEE | 61.72 | 23954790 | |
| 299 | Acetylation | LVAAGLCKRVQVQFS HHHHHHCCEEEEEEE | 61.72 | 25381059 | |
| 299 | Ubiquitination | LVAAGLCKRVQVQFS HHHHHHCCEEEEEEE | 61.72 | 23749301 | |
| 328 | Phosphorylation | TYGTATKSDEEIIDI CCCCCCCCHHHHHHH | 45.99 | 27717283 | |
| 337 | Phosphorylation | EEIIDIISKNFDLRP HHHHHHHHHCCCCCC | 23.14 | 21551504 | |
| 338 | Acetylation | EIIDIISKNFDLRPG HHHHHHHHCCCCCCC | 51.75 | 24489116 | |
| 338 | Ubiquitination | EIIDIISKNFDLRPG HHHHHHHHCCCCCCC | 51.75 | 23749301 | |
| 349 | Ubiquitination | LRPGVLVKELDLARP CCCCEEEEEEECCCC | 48.69 | 23749301 | |
| 349 | Acetylation | LRPGVLVKELDLARP CCCCEEEEEEECCCC | 48.69 | 24489116 | |
| 376 | Ubiquitination | NQEYPWEKPKTLKF- CCCCCCCCCCCCCC- | 48.20 | 17644757 | |
| 376 | Acetylation | NQEYPWEKPKTLKF- CCCCCCCCCCCCCC- | 48.20 | 24489116 | |
| 378 | Ubiquitination | EYPWEKPKTLKF--- CCCCCCCCCCCC--- | 77.03 | 17644757 | |
| 378 | Acetylation | EYPWEKPKTLKF--- CCCCCCCCCCCC--- | 77.03 | 24489116 | |
| 379 | Phosphorylation | YPWEKPKTLKF---- CCCCCCCCCCC---- | 43.65 | 21440633 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of METK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of METK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of METK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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