DUS2_YEAST - dbPTM
DUS2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DUS2_YEAST
UniProt AC P53720
Protein Name tRNA-dihydrouridine(20) synthase [NAD(P)+]
Gene Name SMM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 384
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20 in cytoplasmic tRNAs..
Protein Sequence MVTYAGKLVLAPMVRAGELPTRLMALAHGADLVWSPEIIDKKLIQCVRKENTALQTVDYVVPSKVQTRPETLVFRTYPKLESSKLIFQIGSASPALATQAALKVINDVSGIDINAGCPKHFSIHSGMGSALLRTPDTLCLILKELVKNVGNPHSKPISVKIRLLDTKQDTLQLVKRLCATGITNLTVHCRKTEMRNREQPITDYIAEIYEICQANNVSLIVNGAIRDRSHFHDLQANHWKNTNIGGMIAECAERDPTVFDHTSKPSEDGPSWVVACREFIQWATKFDNHIGNTKYMLSRIVPGKSVFFQYFARCKSPEEVSFVLKQLNDDGSAQTDPSEYLENCRAQEKALKNANAIAKQKRKQTDHIGSDTKKQKVVPLPTDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Acetylation-MVTYAGKLVLAPMV
-CCCCCCEEEECCCC		27.5325381059
154PhosphorylationKNVGNPHSKPISVKI
HHCCCCCCCCEEEEE		41.1919795423
257PhosphorylationECAERDPTVFDHTSK
HHHHHCCCCCCCCCC		37.7929688323
262PhosphorylationDPTVFDHTSKPSEDG
CCCCCCCCCCCCCCC		40.0529688323
263PhosphorylationPTVFDHTSKPSEDGP
CCCCCCCCCCCCCCC		38.8729688323
266PhosphorylationFDHTSKPSEDGPSWV
CCCCCCCCCCCCCHH		52.6429688323
271PhosphorylationKPSEDGPSWVVACRE
CCCCCCCCHHHHHHH		37.7229688323
373AcetylationDHIGSDTKKQKVVPL
CCCCCCCCCCEEECC		59.1925381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DUS2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DUS2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DUS2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TAD3_YEASTTAD3genetic
19061648
EF1B_YEASTEFB1genetic
19061648
TAN1_YEASTTAN1genetic
19061648
IF2A_YEASTSUI2genetic
19061648
SLS1_YEASTSLS1genetic
19061648
EF1A_YEASTTEF2genetic
19061648
HIR2_YEASTHIR2genetic
19061648
YBF5_YEASTYBL055Cgenetic
20093466
SLT11_YEASTECM2genetic
20093466
PFF1_YEASTPFF1genetic
20093466
MBA1_YEASTMBA1genetic
20093466
YB9F_YEASTYBR259Wgenetic
20093466
RTK1_YEASTRTK1genetic
20093466
MAF1_YEASTMAF1genetic
20093466
TRM1_YEASTTRM1genetic
20093466
LSM6_YEASTLSM6genetic
20093466
YGZE_YEASTYGL260Wgenetic
20093466
TAN1_YEASTTAN1genetic
20093466
AAKG_YEASTSNF4genetic
20093466
RS27B_YEASTRPS27Bgenetic
20093466
NDT80_YEASTNDT80genetic
20093466
PTH_YEASTPTH1genetic
20093466
FMC1_YEASTFMC1genetic
20093466
YKE4_YEASTYKE4genetic
20093466
ALN_YEASTDAL1genetic
20093466
BZRD_YEASTIRC24genetic
20093466
HS150_YEASTHSP150genetic
20093466
PUT3_YEASTPUT3genetic
20093466
YPS1_YEASTYPS1genetic
20093466
RAD10_YEASTRAD10genetic
20093466
WSC3_YEASTWSC3genetic
20093466
MAF1_YEASTMAF1genetic
27708008
TRM1_YEASTTRM1genetic
27708008
LSM6_YEASTLSM6genetic
27708008
TAN1_YEASTTAN1genetic
27708008
NDT80_YEASTNDT80genetic
27708008
YKE4_YEASTYKE4genetic
27708008
BZRD_YEASTIRC24genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DUS2_YEAST

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Related Literatures of Post-Translational Modification

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