TAN1_YEAST - dbPTM
TAN1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAN1_YEAST
UniProt AC P53072
Protein Name tRNA acetyltransferase TAN1
Gene Name TAN1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 289
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Probable tRNA acetyltransferase required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs. Binds RNA..
Protein Sequence MGEKRNRNGKDANSQNRKKFKVSSGFLDPGTSGIYATCSRRHERQAAQELQLLFEEKFQELYGDIKEGEDESENDEKKDLSIEDQIKKELQELKGEETGKDLSSGETKKKDPLAFIDLNCECVTFCKTRKPIVPEEFVLSIMKDLADPKNMVKRTRYVQKLTPITYSCNAKMEQLIKLANLVIGPHFHDPSNVKKNYKFAVEVTRRNFNTIERMDIINQVVKLVNKEGSEFNHTVDLKNYDKLILVECFKSNIGMCVVDGDYKTKYRKYNVQQLYESKFRKDEDKSVKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
62PhosphorylationEEKFQELYGDIKEGE
HHHHHHHHCCHHCCC		16.4022369663
72PhosphorylationIKEGEDESENDEKKD
HHCCCCCCCCHHHCC		54.7622369663
81PhosphorylationNDEKKDLSIEDQIKK
CHHHCCCCHHHHHHH		33.7822369663
94AcetylationKKELQELKGEETGKD
HHHHHHHCCCCCCCC		64.6224489116
98PhosphorylationQELKGEETGKDLSSG
HHHCCCCCCCCCCCC		45.2728889911
100AcetylationLKGEETGKDLSSGET
HCCCCCCCCCCCCCC		64.0224489116
149AcetylationMKDLADPKNMVKRTR
HHHHCCCCHHHHHHH		59.2224489116
226AcetylationQVVKLVNKEGSEFNH
HHHHHHCCCCCCCCE		56.8424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAN1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAN1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAN1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IMB1_YEASTKAP95physical
16554755
IMA1_YEASTSRP1physical
16554755
PUS1_YEASTPUS1physical
16554755
PAP2_YEASTPAP2genetic
18443146
RRP6_YEASTRRP6genetic
18443146
MET22_YEASTMET22genetic
18443146
XRN2_YEASTRAT1genetic
18443146
SSB1_YEASTSSB1physical
19536198
EF1A_YEASTTEF2genetic
22895820
TRM44_YEASTTRM44genetic
22895820
MET22_YEASTMET22genetic
22895820
RPA14_YEASTRPA14genetic
27708008
UTP5_YEASTUTP5genetic
27708008
ARP4_YEASTARP4genetic
27708008
EI2BB_YEASTGCD7genetic
27708008
UTP15_YEASTUTP15genetic
27708008
SYLC_YEASTCDC60genetic
27708008
DEP1_YEASTDEP1genetic
27708008
NCL1_YEASTNCL1genetic
27708008
NU170_YEASTNUP170genetic
27708008
GAL10_YEASTGAL10genetic
27708008
RKM3_YEASTRKM3genetic
27708008
MBA1_YEASTMBA1genetic
27708008
HPC2_YEASTHPC2genetic
27708008
RV161_YEASTRVS161genetic
27708008
ATG9_YEASTATG9genetic
27708008
RL41A_YEASTRPL41Agenetic
27708008
RL41B_YEASTRPL41Agenetic
27708008
MGMT_YEASTMGT1genetic
27708008
MAF1_YEASTMAF1genetic
27708008
SOK1_YEASTSOK1genetic
27708008
TRM1_YEASTTRM1genetic
27708008
DPB4_YEASTDPB4genetic
27708008
IPK1_YEASTIPK1genetic
27708008
SHE9_YEASTSHE9genetic
27708008
RAD4_YEASTRAD4genetic
27708008
YFF4_YEASTYFL054Cgenetic
27708008
PSA3_YEASTPRE9genetic
27708008
THI4_YEASTTHI4genetic
27708008
ICE2_YEASTICE2genetic
27708008
PEX2_YEASTPEX2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
HAP4_YEASTHAP4genetic
27708008
FEN1_YEASTRAD27genetic
27708008
XPOT_YEASTLOS1genetic
27708008
TRK2_YEASTTRK2genetic
27708008
TRM2_YEASTTRM2genetic
27708008
RL6B_YEASTRPL6Bgenetic
27708008
SOK2_YEASTSOK2genetic
27708008
RL36A_YEASTRPL36Agenetic
27708008
TMA23_YEASTTMA23genetic
27708008
DUS2_YEASTSMM1genetic
27708008
IRA2_YEASTIRA2genetic
27708008
ULS1_YEASTULS1genetic
27708008
BUD7_YEASTBUD7genetic
27708008
YP013_YEASTCMR3genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAN1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-72, AND MASSSPECTROMETRY.

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