| UniProt ID | TRM1_YEAST | |
|---|---|---|
| UniProt AC | P15565 | |
| Protein Name | tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial | |
| Gene Name | TRM1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 570 | |
| Subcellular Localization |
Isoform 1: Mitochondrion. Isoform 2: Mitochondrion. Nucleus inner membrane Peripheral membrane protein Nucleoplasmic side. Predominantly targeted to the nucleus. |
|
| Protein Description | Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Required for the modification of both mitochondrial and cytoplasmic tRNAs.. | |
| Protein Sequence | MEGFFRIPLKRANLHGMLKAAISKIKANFTAYGAPRINIEDFNIVKEGKAEILFPKKETVFYNPIQQFNRDLSVTCIKAWDNLYGEECGQKRNNKKSKKKRCAETNDDSSKRQKMGNGSPKEAVGNSNRNEPYINILEALSATGLRAIRYAHEIPHVREVIANDLLPEAVESIKRNVEYNSVENIVKPNLDDANVLMYRNKATNNKFHVIDLDPYGTVTPFVDAAIQSIEEGGLMLVTCTDLSVLAGNGYPEKCFALYGGANMVSHESTHESALRLVLNLLKQTAAKYKKTVEPLLSLSIDFYVRVFVKVKTSPIEVKNVMSSTMTTYHCSRCGSYHNQPLGRISQREGRNNKTFTKYSVAQGPPVDTKCKFCEGTYHLAGPMYAGPLHNKEFIEEVLRINKEEHRDQDDTYGTRKRIEGMLSLAKNELSDSPFYFSPNHIASVIKLQVPPLKKVVAGLGSLGFECSLTHAQPSSLKTNAPWDAIWYVMQKCDDEKKDLSKMNPNTTGYKILSAMPGWLSGTVKSEYDSKLSFAPNEQSGNIEKLRKLKIVRYQENPTKNWGPKARPNTS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 (in isoform 2) | Acetylation | - | 11.66 | 15911569 | |
| 17 | Acetylation | KRANLHGMLKAAISK CCCCHHHHHHHHHHH | 2.12 | - | |
| 23 | Phosphorylation | GMLKAAISKIKANFT HHHHHHHHHHHHCCE | 24.49 | 23749301 | |
| 26 | Acetylation | KAAISKIKANFTAYG HHHHHHHHHCCEECC | 40.80 | 22865919 | |
| 109 | Phosphorylation | CAETNDDSSKRQKMG HHCCCCCHHHHHHCC | 40.39 | 27717283 | |
| 110 | Phosphorylation | AETNDDSSKRQKMGN HCCCCCHHHHHHCCC | 38.56 | 27717283 | |
| 119 | Phosphorylation | RQKMGNGSPKEAVGN HHHCCCCCHHHHHCC | 36.48 | 25752575 | |
| 133 | Phosphorylation | NSNRNEPYINILEAL CCCCCCCCHHHHHHH | 10.62 | 21440633 | |
| 174 | Acetylation | PEAVESIKRNVEYNS HHHHHHHHHHCCCCC | 47.39 | 24489116 | |
| 322 | Phosphorylation | IEVKNVMSSTMTTYH EEEEECHHCCCCEEE | 20.55 | 27017623 | |
| 328 | Phosphorylation | MSSTMTTYHCSRCGS HHCCCCEEECCCCCC | 7.52 | 27017623 | |
| 331 | Phosphorylation | TMTTYHCSRCGSYHN CCCEEECCCCCCCCC | 19.79 | 27017623 | |
| 357 | Acetylation | RNNKTFTKYSVAQGP CCCCCCCEEEECCCC | 31.19 | 24489116 | |
| 506 | Phosphorylation | LSKMNPNTTGYKILS HHHCCCCCCCHHHHH | 23.90 | 28889911 | |
| 509 | Phosphorylation | MNPNTTGYKILSAMP CCCCCCCHHHHHCCC | 7.86 | 28889911 | |
| 532 | Phosphorylation | SEYDSKLSFAPNEQS HHHHHCCCCCCCCCC | 24.09 | 19684113 | |
| 544 | Acetylation | EQSGNIEKLRKLKIV CCCCCHHHHHEEEEE | 50.20 | 24489116 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TRM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TRM1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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