TRM10_YEAST - dbPTM
TRM10_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRM10_YEAST
UniProt AC Q12400
Protein Name tRNA (guanine(9)-N1)-methyltransferase {ECO:0000305|PubMed:12702816}
Gene Name TRM10 {ECO:0000303|PubMed:12702816}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 293
Subcellular Localization Cytoplasm . Nucleus .
Protein Description S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs..
Protein Sequence MSNDEINQNEEKVKRTPPLPPVPEGMSKKQWKKMCKRQRWEENKAKYNAERRVKKKRLRHERSAKIQEYIDRGEEVPQELIREPRINVNQTDSGIEIILDCSFDELMNDKEIVSLSNQVTRAYSANRRANHFAEIKVAPFDKRLKQRFETTLKNTNYENWNHFKFLPDDKIMFGDEHISKDKIVYLTADTEEKLEKLEPGMRYIVGGIVDKNRYKELCLKKAQKMGIPTRRLPIDEYINLEGRRVLTTTHVVQLMLKYFDDHNWKNAFESVLPPRKLDAEAKSASSSPAPKDT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNDEINQN
------CCHHHHHHC		53.6522369663
16PhosphorylationNEEKVKRTPPLPPVP
CHHHHCCCCCCCCCC		24.4422369663
179PhosphorylationMFGDEHISKDKIVYL
ECCCCCCCCCEEEEE		36.3928889911
187PhosphorylationKDKIVYLTADTEEKL
CCEEEEEECCCHHHH		12.5628889911
190PhosphorylationIVYLTADTEEKLEKL
EEEEECCCHHHHHHC		43.5128889911
283PhosphorylationKLDAEAKSASSSPAP
HCCHHHHHHCCCCCC		40.1925005228
285PhosphorylationDAEAKSASSSPAPKD
CHHHHHHCCCCCCCC		38.1425005228
286PhosphorylationAEAKSASSSPAPKDT
HHHHHHCCCCCCCCC		39.8025005228
287PhosphorylationEAKSASSSPAPKDT-
HHHHHCCCCCCCCC-		23.6825005228
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRM10_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRM10_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRM10_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PUS1_YEASTPUS1genetic
18314501
XPOT_YEASTLOS1genetic
18314501
TAD2_YEASTTAD2genetic
19061648
LTV1_YEASTLTV1genetic
19061648
MRT4_YEASTMRT4genetic
19061648
NOP15_YEASTNOP15genetic
19061648
H1_YEASTHHO1genetic
19061648
IF2G_YEASTGCD11genetic
19061648
PUS3_YEASTDEG1genetic
19547744
SRS2_YEASTSRS2genetic
21459050
NTM1_YEASTTAE1genetic
27708008
RV161_YEASTRVS161genetic
27708008
PEX19_YEASTPEX19genetic
27708008
BRE1_YEASTBRE1genetic
27708008
MAF1_YEASTMAF1genetic
27708008
TRM1_YEASTTRM1genetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
PFKA2_YEASTPFK2genetic
27708008
AF9_YEASTYAF9genetic
27708008
VPS27_YEASTVPS27genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
ELP4_YEASTELP4genetic
27708008
HSP7F_YEASTSSE1genetic
27708008
PUS1_YEASTPUS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRM10_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND THR-16, AND MASSSPECTROMETRY.

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