| UniProt ID | BRE1_YEAST | |
|---|---|---|
| UniProt AC | Q07457 | |
| Protein Name | E3 ubiquitin-protein ligase BRE1 | |
| Gene Name | BRE1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 700 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme RAD6/UBC2. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. Also modulates the formation of double-strand breaks during meiosis.. | |
| Protein Sequence | MTAEPATKKIKLELSDPSEPLTQSDVIAFQKEALFRCINRRRVDFEALRKQYELSRRECIDVSRKLANIMALIVTLARFIETFCTDANEKQLCREIAQGDETLIVQRSDSFMKLLTKYGKPNTTDSNTNSNASDHIQELTTELKNLRKSKEELFYENSQLTEEISALKEYYTNIIRKYDRDESFTIKRVFKEDKTDAVKELREDEKESNENNIKSGNKDSSAINGDNTSKKSEKGDELVQAEDERKEDAENEKLELDLKFSDLRAEINSLSSTIKDLENIRRENEEELIKTRSEVSNLKKQQIAAADQDPDFKSYDHESLLAKIQHLTEQNAELSEINSSFLSKFQVLAKEKEIYTKKVREEFQKSLDSLVEMNSSLEKDVVRIRTARDDLLSKIAILEAEKSKTEVLSDLQHAIDILKEQWTKIDQRSNDTKSSSTQDALIKEIQDLEKGFRELSDLTHKKYSEIINHESVISKLTVEKTKADQKYFAAMRSKDSILIEIKTLSKSLSKSNELILQLKDSDRLLQQKIGNLHKQLDLSQNNERRLIDSSKTETLKIIDLNNTSTKLKRSLEKLQEESNKSIADMTHLETKLNDTEIELKHFKQKASHLESKCEKLHDTLFRGNNKNKGSSDEALVEELANFRTLVYCSLCSKNWKNMAIKTCGHVFCENCCKERLAARMRKCPTCNKAFSSNDLLTVHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Acetylation | MTAEPATKKIKLELS CCCCCCCCEEEEECC | 55.39 | 25381059 | |
| 9 | Acetylation | TAEPATKKIKLELSD CCCCCCCEEEEECCC | 40.49 | 24489116 | |
| 11 | Acetylation | EPATKKIKLELSDPS CCCCCEEEEECCCCC | 44.80 | 24489116 | |
| 15 | Phosphorylation | KKIKLELSDPSEPLT CEEEEECCCCCCCCC | 37.79 | 21440633 | |
| 183 | Phosphorylation | RKYDRDESFTIKRVF HHHCCCCCCCEEEHH | 31.79 | 30377154 | |
| 187 | Acetylation | RDESFTIKRVFKEDK CCCCCCEEEHHHCCC | 39.18 | 24489116 | |
| 191 | Acetylation | FTIKRVFKEDKTDAV CCEEEHHHCCCCHHH | 63.25 | 25381059 | |
| 194 | Acetylation | KRVFKEDKTDAVKEL EEHHHCCCCHHHHHH | 49.77 | 25381059 | |
| 218 | Acetylation | NNIKSGNKDSSAING CCCCCCCCCCCCCCC | 63.61 | 24489116 | |
| 221 | Phosphorylation | KSGNKDSSAINGDNT CCCCCCCCCCCCCCC | 43.21 | 23749301 | |
| 231 | Acetylation | NGDNTSKKSEKGDEL CCCCCCCCCCCCCHH | 64.71 | 25381059 | |
| 275 | Acetylation | NSLSSTIKDLENIRR HHHHHHHHHHHHHHH | 57.24 | 24489116 | |
| 313 | Acetylation | ADQDPDFKSYDHESL CCCCCCCCCCCHHHH | 56.33 | 24489116 | |
| 434 | Phosphorylation | QRSNDTKSSSTQDAL HCCCCCCCCHHHHHH | 31.45 | 19823750 | |
| 435 | Phosphorylation | RSNDTKSSSTQDALI CCCCCCCCHHHHHHH | 38.67 | 19823750 | |
| 436 | Phosphorylation | SNDTKSSSTQDALIK CCCCCCCHHHHHHHH | 36.86 | 19823750 | |
| 437 | Phosphorylation | NDTKSSSTQDALIKE CCCCCCHHHHHHHHH | 32.20 | 19823750 | |
| 443 | Acetylation | STQDALIKEIQDLEK HHHHHHHHHHHHHHH | 50.00 | 24489116 | |
| 463 | Phosphorylation | SDLTHKKYSEIINHE HHCCCHHHHHHHCCH | 19.15 | 28889911 | |
| 471 | Phosphorylation | SEIINHESVISKLTV HHHHCCHHHHHHHHH | 19.73 | 28889911 | |
| 581 | Phosphorylation | LQEESNKSIADMTHL HHHHHHCCHHHHHHH | 27.53 | 28889911 | |
| 600 | Acetylation | NDTEIELKHFKQKAS CCCHHHHHHHHHHHH | 33.92 | 24489116 | |
| 630 | Phosphorylation | GNNKNKGSSDEALVE CCCCCCCCCHHHHHH | 35.90 | 30377154 | |
| 631 | Phosphorylation | NNKNKGSSDEALVEE CCCCCCCCHHHHHHH | 48.41 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BRE1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BRE1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BRE1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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