| UniProt ID | SLK19_YEAST | |
|---|---|---|
| UniProt AC | Q08581 | |
| Protein Name | Kinetochore protein SLK19 | |
| Gene Name | SLK19 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 821 | |
| Subcellular Localization | Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Spindle midzone during anaphase. During meiotic prophase localizes to the centromere and remains there until anaph | |
| Protein Description | Has a role in spindle assembly and stability. Required to ensure a timely exit form mitosis. Essential to maintain pre-anaphase spindle polarity. Associates to the plus ends of the microtubules at the kinetochore and spindle midzone. A component of the FEAR (CDC14 Early Anaphase Release) network which promotes CDC14 release from the nucleolus during early anaphase. Required for proper chromosome segregation during meiosis I where it prevents premature sister chromatid separation.. | |
| Protein Sequence | MNEVPTTPVRLILGQAQQREQNSENCSQERNPRTFNSEPDSSFNSPGSSQFVIHPHEPLEKEKDEKQDLDRSIDYGRSSALNNKNNANPLENIDINKMFDDKKSDSGTNDDKGGASTSDKHVLALNYSPIRVEMNSSEKRSDKNVDVDENDKEGSHINKKLKLQLESVPDLKQSSTKDIINDKEEIMSSPMAIDMIETNISPNKFIINDGVERNDSFNINTDTLKLENDINEKQQEEDFIKSNSNNVVNIDNAYKEKEDEENDITNSHINRLTPLYETSARESNSNEEGRNDYDDDNQLDIRHDNFQIVAKRNEELTDQIYHLNQMLNSLISKNESLSFQYEKLNKNHQLLIDLTNEKLDKLNTERESDIAKVEKFKKRIKELNTEIKVLNSNQKILQEKFDASITEVNHIKGEHENTVNTLQQNEKILNDKNVELENMKAELKGNNDKLSEYETTLNDLNSRIVQLNDKIESTDIVLKSKENELDNLKLSLKETLSISKDFNDSDLIGQINELISTKNNLQQKMDDLNNLNDDNLKVVQDKLIKNEETLKLKEAEIDSLNSEMDELKKQITSKDDEFKMWQSKYETVEDEAKIRNAEVTELNGDIEDLKESKLHLEETITELENKVHKLENECELEKQKFEKTSLELESLQLKNSNIQAEHIKELENLHENLISLQNELKISSDRITTLTKENEVLMEQNNNNNNSVTLSNDQKDRDDEKIKSLGKQVQDWKEKYEAKEKDTNKRLKLLAEDLYIQYSSKHEQKVKLLKKGYENKYQNKFDQLNLENKTLSEEIEQLNKQLSSEREEKQELLKLLENEKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MNEVPTTPVRLIL --CCCCCCCCHHHHH | 49.24 | 24909858 | |
| 7 | Phosphorylation | -MNEVPTTPVRLILG -CCCCCCCCHHHHHH | 17.45 | 28152593 | |
| 23 | Phosphorylation | AQQREQNSENCSQER HHHHHHHCCCCCCCC | 29.85 | 23749301 | |
| 27 | Phosphorylation | EQNSENCSQERNPRT HHHCCCCCCCCCCCC | 46.81 | 17563356 | |
| 37 | Phosphorylation | RNPRTFNSEPDSSFN CCCCCCCCCCCCCCC | 46.44 | 27017623 | |
| 41 | Phosphorylation | TFNSEPDSSFNSPGS CCCCCCCCCCCCCCC | 47.77 | 23749301 | |
| 42 | Phosphorylation | FNSEPDSSFNSPGSS CCCCCCCCCCCCCCC | 35.51 | 17563356 | |
| 45 | Phosphorylation | EPDSSFNSPGSSQFV CCCCCCCCCCCCCEE | 28.73 | 17563356 | |
| 48 | Phosphorylation | SSFNSPGSSQFVIHP CCCCCCCCCCEEECC | 25.09 | 19779198 | |
| 49 | Phosphorylation | SFNSPGSSQFVIHPH CCCCCCCCCEEECCC | 33.29 | 23749301 | |
| 72 | Phosphorylation | EKQDLDRSIDYGRSS CCCCHHHHHHHHHHH | 21.34 | 22369663 | |
| 75 | Phosphorylation | DLDRSIDYGRSSALN CHHHHHHHHHHHHHC | 16.87 | 20377248 | |
| 78 | Phosphorylation | RSIDYGRSSALNNKN HHHHHHHHHHHCCCC | 18.66 | 21551504 | |
| 104 | Phosphorylation | KMFDDKKSDSGTNDD HHCCCCCCCCCCCCC | 42.63 | 17287358 | |
| 106 | Phosphorylation | FDDKKSDSGTNDDKG CCCCCCCCCCCCCCC | 55.39 | 24961812 | |
| 108 | Phosphorylation | DKKSDSGTNDDKGGA CCCCCCCCCCCCCCC | 39.15 | 24961812 | |
| 120 | Acetylation | GGASTSDKHVLALNY CCCCCCCCEEEEEEC | 35.07 | 24489116 | |
| 127 | Phosphorylation | KHVLALNYSPIRVEM CEEEEEECCCEEEEC | 19.37 | 22890988 | |
| 128 | Phosphorylation | HVLALNYSPIRVEMN EEEEEECCCEEEECC | 16.87 | 22369663 | |
| 136 | Phosphorylation | PIRVEMNSSEKRSDK CEEEECCCCCCCCCC | 38.27 | 20377248 | |
| 137 | Phosphorylation | IRVEMNSSEKRSDKN EEEECCCCCCCCCCC | 41.98 | 24909858 | |
| 141 | Phosphorylation | MNSSEKRSDKNVDVD CCCCCCCCCCCCCCC | 65.09 | 28889911 | |
| 155 | Phosphorylation | DENDKEGSHINKKLK CCCCCCCCHHHHHHH | 23.45 | 28889911 | |
| 167 | Phosphorylation | KLKLQLESVPDLKQS HHHHHHHCCCCCCCC | 47.76 | 28152593 | |
| 174 | Phosphorylation | SVPDLKQSSTKDIIN CCCCCCCCCCCCCCC | 38.09 | 19779198 | |
| 175 | Phosphorylation | VPDLKQSSTKDIIND CCCCCCCCCCCCCCC | 36.66 | 19779198 | |
| 188 | Phosphorylation | NDKEEIMSSPMAIDM CCHHHHHCCCCHHHH | 36.63 | 22369663 | |
| 189 | Phosphorylation | DKEEIMSSPMAIDMI CHHHHHCCCCHHHHH | 11.00 | 22369663 | |
| 198 | Phosphorylation | MAIDMIETNISPNKF CHHHHHHCCCCCCCE | 27.25 | 22369663 | |
| 201 | Phosphorylation | DMIETNISPNKFIIN HHHHCCCCCCCEEEC | 25.21 | 22369663 | |
| 216 | Phosphorylation | DGVERNDSFNINTDT CCCCCCCCCCCCCCC | 24.60 | 22369663 | |
| 221 | Phosphorylation | NDSFNINTDTLKLEN CCCCCCCCCCEEECC | 26.94 | 21440633 | |
| 223 | Phosphorylation | SFNINTDTLKLENDI CCCCCCCCEEECCCC | 24.61 | 21440633 | |
| 233 | Ubiquitination | LENDINEKQQEEDFI ECCCCCHHHHHHHHH | 53.44 | 23749301 | |
| 242 | Phosphorylation | QEEDFIKSNSNNVVN HHHHHHHHCCCCEEE | 40.45 | 19795423 | |
| 244 | Phosphorylation | EDFIKSNSNNVVNID HHHHHHCCCCEEECC | 36.55 | 21440633 | |
| 265 | Phosphorylation | EDEENDITNSHINRL HHCCCCCCHHHHHHH | 33.27 | 24930733 | |
| 267 | Phosphorylation | EENDITNSHINRLTP CCCCCCHHHHHHHHH | 19.66 | 22369663 | |
| 273 | Phosphorylation | NSHINRLTPLYETSA HHHHHHHHHHHCCCC | 14.17 | 22369663 | |
| 276 | Phosphorylation | INRLTPLYETSARES HHHHHHHHCCCCCCC | 20.54 | 22369663 | |
| 278 | Phosphorylation | RLTPLYETSARESNS HHHHHHCCCCCCCCC | 17.71 | 22369663 | |
| 279 | Phosphorylation | LTPLYETSARESNSN HHHHHCCCCCCCCCC | 17.25 | 22369663 | |
| 283 | Phosphorylation | YETSARESNSNEEGR HCCCCCCCCCCCCCC | 39.75 | 22369663 | |
| 285 | Phosphorylation | TSARESNSNEEGRND CCCCCCCCCCCCCCC | 55.70 | 22369663 | |
| 293 | Phosphorylation | NEEGRNDYDDDNQLD CCCCCCCCCCCCCEE | 25.48 | 22369663 | |
| 343 | Acetylation | SLSFQYEKLNKNHQL CHHHHHHHHCCCCCE | 53.04 | 24489116 | |
| 473 | Phosphorylation | QLNDKIESTDIVLKS HHHHHHCCCCEEECC | 34.55 | 27017623 | |
| 559 | Phosphorylation | LKEAEIDSLNSEMDE HHHHHHHHHHHHHHH | 34.80 | 28889911 | |
| 644 | Phosphorylation | EKQKFEKTSLELESL HHHHHHHHHHHHHHH | 31.20 | 24909858 | |
| 656 | Phosphorylation | ESLQLKNSNIQAEHI HHHHCCCCCCCHHHH | 33.45 | 21440633 | |
| 675 | Phosphorylation | NLHENLISLQNELKI HHHHHHHHHHHHHHC | 27.37 | 26447709 | |
| 688 | Phosphorylation | KISSDRITTLTKENE HCCCCCEEECCHHHH | 19.35 | 28889911 | |
| 689 | Phosphorylation | ISSDRITTLTKENEV CCCCCEEECCHHHHH | 30.02 | 28889911 | |
| 691 | Phosphorylation | SDRITTLTKENEVLM CCCEEECCHHHHHHC | 33.93 | 28889911 | |
| 692 | Ubiquitination | DRITTLTKENEVLME CCEEECCHHHHHHCC | 62.75 | 19722269 | |
| 707 | Phosphorylation | QNNNNNNSVTLSNDQ CCCCCCCCEEECCCC | 20.71 | 28152593 | |
| 709 | Phosphorylation | NNNNNSVTLSNDQKD CCCCCCEEECCCCCC | 25.04 | 24961812 | |
| 711 | Phosphorylation | NNNSVTLSNDQKDRD CCCCEEECCCCCCCC | 29.06 | 24909858 | |
| 761 | Acetylation | LYIQYSSKHEQKVKL HHHHHCCHHHHHHHH | 45.26 | 24489116 | |
| 803 | Phosphorylation | EQLNKQLSSEREEKQ HHHHHHHHCHHHHHH | 27.88 | 28889911 | |
| 804 | Phosphorylation | QLNKQLSSEREEKQE HHHHHHHCHHHHHHH | 49.63 | 28889911 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLK19_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLK19_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-188; SER-189;SER-201; SER-216 AND THR-273, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-42; SER-45;SER-216 AND SER-283, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 AND SER-128, ANDMASS SPECTROMETRY. | |
