| UniProt ID | THP1_YEAST | |
|---|---|---|
| UniProt AC | Q08231 | |
| Protein Name | Nuclear mRNA export protein THP1 | |
| Gene Name | THP1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 455 | |
| Subcellular Localization | Nucleus envelope . Localizes to the nuclear pores. | |
| Protein Description | Component of the SAC3-THP1 complex, which functions in transcription-coupled mRNA export from the nucleus to the cytoplasm. SAC3-THP1 functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket), by association with components of the nuclear mRNA export machinery (MEX67-MTR2 and SUB2) in the nucleoplasm and the nucleoporin NUP1 at the nuclear basket. THP1 binds to RNA in vitro.. | |
| Protein Sequence | MDMANQLLDELAHGNFSHLTLNLSQNGREIAILQKQLTGFDDKQLETFVEQHPAMPNDTRFKIMCTSFLNYARDVDPWSAWSSSDLIFEFYQCLINCLINDNAPHIEMLIPVATRETEFIINLAGKLDSFHLQLHTRSHQFLSHISSILSRLFNSIKPPRGNASSTNIPGKQRILLYLVNKLNNIYFRIESPQLCSNIFKNFQPKSMLAHFNEYQLDQQIEYRYLLGRYYLLNSQVHNAFVQFNEAFQSLLNLPLTNQAITRNGTRILNYMIPTGLILGKMVKWGPLRPFLSQETIDNWSVLYKHVRYGNIQGVSLWLRQNERHLCARQLLIVLLEKLPMVTYRNLIKTVIKSWTTEWGQNKLPYSLIERVLQLSIGPTFEDPGAQEITIYNGIHSPKNVENVLVTLINLGLLRANCFPQLQLCVVKKTTMIQEIVPPVNERITKMFPAHSHVLW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Phosphorylation | ELAHGNFSHLTLNLS HHHCCCCCCEEEEEC | 22.91 | 29136822 | |
| 20 | Phosphorylation | HGNFSHLTLNLSQNG CCCCCCEEEEECCCC | 14.26 | 29136822 | |
| 24 | Phosphorylation | SHLTLNLSQNGREIA CCEEEEECCCCCEEE | 22.11 | 29136822 | |
| 146 | Phosphorylation | HQFLSHISSILSRLF HHHHHHHHHHHHHHH | 13.10 | 19795423 | |
| 147 | Phosphorylation | QFLSHISSILSRLFN HHHHHHHHHHHHHHH | 27.26 | 19795423 | |
| 150 | Phosphorylation | SHISSILSRLFNSIK HHHHHHHHHHHHHCC | 25.85 | 19795423 | |
| 308 | Phosphorylation | VLYKHVRYGNIQGVS HHHHHHHHCCEEEEE | 17.28 | 26447709 | |
| 315 | Phosphorylation | YGNIQGVSLWLRQNE HCCEEEEEEEHHHCH | 22.20 | 26447709 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
