| UniProt ID | ESC1_YEAST | |
|---|---|---|
| UniProt AC | Q03661 | |
| Protein Name | Silent chromatin protein ESC1 | |
| Gene Name | ESC1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1658 | |
| Subcellular Localization | Nucleus . Concentrated at the nuclear periphery. | |
| Protein Description | Involved in the clustering of telomeres at the nuclear periphery, forming discrete subcompartments that accumulate a complex of histone-binding silencing factors like SIR4. Required for SIR4-mediated anchoring and partitioning of plasmids.. | |
| Protein Sequence | MSKKKETFTPRANKLKLTTPRRKLKILSSLLDADEDSKMKDQHGYSRVHNDKYRVAKPTQHSTLHESISSRRSSHIHNKSLHEDSARALSWVDSLINRGKSILTTLEKEDALFERSLEEERQRFQLHDSLMNKYTGNSKSHQRLIDLRKSQYGTDTSFQNNDEIPLDSFISSPLPDAEDESSSNIDSDKDEDLEGKQSLIKDFDLENDEYELSEEEKNSDGQSSPSIMILSDEEYAEEGALQDVSNDEYAEEEGQVERKNIGQEQANVENATQISSSDSSEGQNYSEGVEMELEDDIDVESDAEKDESQGAEGTEHSVDFSKYMQPRTDNTKIPVIEKYESDEHKVHQRYSEDGAFDFGSVNISVDDESEDEESQAESYSANAENVYHHNEHELDDKELIEDIESSDSESQSAQESEQGSEDDFEYKMKNEKSTSEETENTSESRDQGFAKDAYTKNKVEQQENDEEPEKDDIIRSSLDKNFHGNNNKSEYSENVLENETDPAIVERENQINDVEGYDVTGKSVESDLHEHSPDNLYDLAARAMLQFQQSRNSNCPQKEEQVSESYLGHSNGSNLSGRSLDESEEQIPLKDFTGENNNNLKTDRGDLSSSVEIEVEKVSEKKLDGSTEKELVPLSTDTTINNSSLGNEDSIYYSLDDADAISENLTDVPLMEIKTTPKYEVVISESVYSSTSYEDNTVAMPPQVEYTSPFMNDPFNSLNDDYEKKHDLLKSTLAALAPAFTKKDAEFVEAGVTKSCLTSTSGHTNIFHTSKETKQVSDLDESTENVTFENENTGDENKNQSKNFPGVANSTDKSTEDNTDEKYFSAINYTNVTGDSSCEDIIETASNVEENLRYCEKDMNEAEMSSGDECVKQNDDGSKTQISFSTDSPDNFQESNDNTEFSSTKYKVRNSDLEDDESLKKELTKAEVVDKLDEEESEDSYEQDYADPEPGNDEGSNENIVKGTKKDTLGIVEPENEKVNKVHEEETLFEANVSSSVNVQNKDMHTDVINQEAQANYEAGERKYYIQNTDTEEAHISIIERIDENAIGNNMEIPERSCVEKTHNEVLFERRATTIENTKALENNTNMHDQVSQACSDSDRDQDSTAEKNVEGSAKHNLDIRVSSSEIESVEPLKPESDRSNIFSSPIRVIGAVVKGVGKVVDVAESFVKKIDVMDSESDDNVDIGDYNQDIFNKSNSTDASVNMKSVSSKERDSDEDEAVILGGVTAEAHNDNGNNSRVINIDPTTNGAYEEDSEVFRQQVKDKENLHKSEEPLVEGLQSEQHFEKKDHSENEEEFDTIYGDITSANIHSNAPDDIKRQQLLKNLSDLENYSQRLIEDSRRGKNQEESDEVNTSRERDLTFEKSVNEKYAGAIEEDTFSELDISIQHPEHEEDLDLSNNQERSIEELNSEPEEAELYELEIEGPTETAASSKMNDDERQRGNIPSTDLPSDPPSDKEEVTDSYPYSNSENITAEKSAPTSPEVYEIFSDTPNEVPMEINDEIPATTLEKHDKTNVTSVLDDRSEHLSSHDVDNEPHDNSINIKVNEGEEPEHQAVDIPVKVEVKEEQEEMPSKSVLEEQKPSMELINDKSSPENNNDEETNREKDKTKAKKKSRKRNYNSRRRKRKITEGSSAASNTKRRRGHEPKSRGQNTHPSVDK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | ANKLKLTTPRRKLKI CCCCCCCCHHHHHHH | 25.82 | 19779198 | |
| 25 | Acetylation | TTPRRKLKILSSLLD CCHHHHHHHHHHHCC | 44.64 | 24489116 | |
| 28 | Phosphorylation | RRKLKILSSLLDADE HHHHHHHHHHCCCCC | 23.55 | 30377154 | |
| 29 | Phosphorylation | RKLKILSSLLDADED HHHHHHHHHCCCCCC | 29.52 | 30377154 | |
| 52 | Acetylation | YSRVHNDKYRVAKPT CCCCCCCCCEECCCC | 40.03 | 25381059 | |
| 67 | Phosphorylation | QHSTLHESISSRRSS CCCCHHHHHHHHCCC | 19.61 | 27017623 | |
| 70 | Phosphorylation | TLHESISSRRSSHIH CHHHHHHHHCCCCCC | 30.00 | 27017623 | |
| 79 | Acetylation | RSSHIHNKSLHEDSA CCCCCCCCCCCHHHH | 39.99 | 25381059 | |
| 80 | Phosphorylation | SSHIHNKSLHEDSAR CCCCCCCCCCHHHHH | 40.03 | 30377154 | |
| 85 | Phosphorylation | NKSLHEDSARALSWV CCCCCHHHHHHHHHH | 19.37 | 28889911 | |
| 90 | Phosphorylation | EDSARALSWVDSLIN HHHHHHHHHHHHHHH | 24.86 | 28889911 | |
| 101 | Phosphorylation | SLINRGKSILTTLEK HHHHCCCCHHHHHHH | 26.17 | 19823750 | |
| 104 | Phosphorylation | NRGKSILTTLEKEDA HCCCCHHHHHHHHHH | 27.89 | 19795423 | |
| 105 | Phosphorylation | RGKSILTTLEKEDAL CCCCHHHHHHHHHHH | 29.49 | 19823750 | |
| 129 | Phosphorylation | QRFQLHDSLMNKYTG HHHHHHHHHHHHHCC | 20.83 | 23749301 | |
| 133 | Acetylation | LHDSLMNKYTGNSKS HHHHHHHHHCCCCCC | 30.17 | 24489116 | |
| 140 | Phosphorylation | KYTGNSKSHQRLIDL HHCCCCCCHHHHHHH | 25.36 | 17287358 | |
| 210 | Phosphorylation | FDLENDEYELSEEEK HCCCCCCEECCHHHC | 25.65 | 29688323 | |
| 213 | Phosphorylation | ENDEYELSEEEKNSD CCCCEECCHHHCCCC | 30.90 | 22369663 | |
| 245 | Phosphorylation | EGALQDVSNDEYAEE CCCCCCCCCHHHHHH | 47.02 | 28889911 | |
| 308 | Phosphorylation | SDAEKDESQGAEGTE CHHHHCHHCCCCCCC | 44.01 | 22369663 | |
| 314 | Phosphorylation | ESQGAEGTEHSVDFS HHCCCCCCCCCCCHH | 23.25 | 22369663 | |
| 317 | Phosphorylation | GAEGTEHSVDFSKYM CCCCCCCCCCHHHHC | 19.70 | 22369663 | |
| 321 | Phosphorylation | TEHSVDFSKYMQPRT CCCCCCHHHHCCCCC | 20.57 | 22369663 | |
| 332 | Acetylation | QPRTDNTKIPVIEKY CCCCCCCCCCEEEEE | 51.79 | 25381059 | |
| 338 | Acetylation | TKIPVIEKYESDEHK CCCCEEEEECCCCCC | 43.10 | 24489116 | |
| 341 | Phosphorylation | PVIEKYESDEHKVHQ CEEEEECCCCCCCCH | 45.25 | 21440633 | |
| 433 | Phosphorylation | YKMKNEKSTSEETEN HHHHCCCCCCHHHCC | 30.87 | 22890988 | |
| 434 | Phosphorylation | KMKNEKSTSEETENT HHHCCCCCCHHHCCC | 51.75 | 22890988 | |
| 435 | Phosphorylation | MKNEKSTSEETENTS HHCCCCCCHHHCCCH | 40.29 | 22890988 | |
| 438 | Phosphorylation | EKSTSEETENTSESR CCCCCHHHCCCHHHH | 30.40 | 22890988 | |
| 441 | Phosphorylation | TSEETENTSESRDQG CCHHHCCCHHHHHHC | 27.86 | 22369663 | |
| 442 | Phosphorylation | SEETENTSESRDQGF CHHHCCCHHHHHHCC | 45.19 | 22369663 | |
| 444 | Phosphorylation | ETENTSESRDQGFAK HHCCCHHHHHHCCHH | 40.71 | 22369663 | |
| 451 | Acetylation | SRDQGFAKDAYTKNK HHHHCCHHHHHHHHH | 40.40 | 22865919 | |
| 454 | Phosphorylation | QGFAKDAYTKNKVEQ HCCHHHHHHHHHHHH | 28.51 | 27017623 | |
| 470 | Acetylation | ENDEEPEKDDIIRSS CCCCCCCHHHHHHHH | 71.99 | 24489116 | |
| 477 | Phosphorylation | KDDIIRSSLDKNFHG HHHHHHHHCCCCCCC | 30.64 | 21440633 | |
| 480 | Acetylation | IIRSSLDKNFHGNNN HHHHHCCCCCCCCCC | 67.80 | 25381059 | |
| 489 | Phosphorylation | FHGNNNKSEYSENVL CCCCCCCHHHHHHHH | 43.84 | 21551504 | |
| 491 | Phosphorylation | GNNNKSEYSENVLEN CCCCCHHHHHHHHCC | 28.51 | 29688323 | |
| 492 | Phosphorylation | NNNKSEYSENVLENE CCCCHHHHHHHHCCC | 20.74 | 21551504 | |
| 500 | Phosphorylation | ENVLENETDPAIVER HHHHCCCCCHHHHHC | 59.88 | 22369663 | |
| 517 | Phosphorylation | QINDVEGYDVTGKSV HCCCCCCCCCCCCCH | 8.17 | 19779198 | |
| 520 | Phosphorylation | DVEGYDVTGKSVESD CCCCCCCCCCCHHHC | 35.67 | 19779198 | |
| 523 | Phosphorylation | GYDVTGKSVESDLHE CCCCCCCCHHHCHHH | 32.25 | 22890988 | |
| 526 | Phosphorylation | VTGKSVESDLHEHSP CCCCCHHHCHHHCCC | 43.23 | 22369663 | |
| 532 | Phosphorylation | ESDLHEHSPDNLYDL HHCHHHCCCCCHHHH | 30.85 | 22369663 | |
| 537 | Phosphorylation | EHSPDNLYDLAARAM HCCCCCHHHHHHHHH | 18.37 | 22890988 | |
| 550 | Phosphorylation | AMLQFQQSRNSNCPQ HHHHHHHHCCCCCCC | 23.73 | 30377154 | |
| 563 | Phosphorylation | PQKEEQVSESYLGHS CCHHHHHCHHHHCCC | 22.11 | 22369663 | |
| 565 | Phosphorylation | KEEQVSESYLGHSNG HHHHHCHHHHCCCCC | 20.39 | 22369663 | |
| 566 | Phosphorylation | EEQVSESYLGHSNGS HHHHCHHHHCCCCCC | 16.80 | 22369663 | |
| 570 | Phosphorylation | SESYLGHSNGSNLSG CHHHHCCCCCCCCCC | 40.88 | 22369663 | |
| 573 | Phosphorylation | YLGHSNGSNLSGRSL HHCCCCCCCCCCCCC | 38.56 | 22369663 | |
| 576 | Phosphorylation | HSNGSNLSGRSLDES CCCCCCCCCCCCCCC | 36.09 | 22369663 | |
| 579 | Phosphorylation | GSNLSGRSLDESEEQ CCCCCCCCCCCCCCC | 43.63 | 22369663 | |
| 583 | Phosphorylation | SGRSLDESEEQIPLK CCCCCCCCCCCCCCC | 46.21 | 22369663 | |
| 593 | Phosphorylation | QIPLKDFTGENNNNL CCCCCCCCCCCCCCC | 54.44 | 28889911 | |
| 602 | Phosphorylation | ENNNNLKTDRGDLSS CCCCCCCCCCCCCCC | 33.81 | 22369663 | |
| 608 | Phosphorylation | KTDRGDLSSSVEIEV CCCCCCCCCCEEEEE | 25.88 | 22369663 | |
| 609 | Phosphorylation | TDRGDLSSSVEIEVE CCCCCCCCCEEEEEE | 45.78 | 22369663 | |
| 610 | Phosphorylation | DRGDLSSSVEIEVEK CCCCCCCCEEEEEEE | 22.01 | 22369663 | |
| 626 | Phosphorylation | SEKKLDGSTEKELVP CCCCCCCCCCCCEEE | 32.81 | 27214570 | |
| 662 | Phosphorylation | LDDADAISENLTDVP CCCHHHHHCCCCCCC | 23.35 | 28889911 | |
| 732 | Phosphorylation | KHDLLKSTLAALAPA HHHHHHHHHHHHHHH | 20.87 | 17287358 | |
| 741 | Phosphorylation | AALAPAFTKKDAEFV HHHHHHHCCCCHHHH | 39.01 | 17287358 | |
| 753 | Phosphorylation | EFVEAGVTKSCLTST HHHHCCCCHHHHHCC | 19.13 | 20377248 | |
| 759 | Phosphorylation | VTKSCLTSTSGHTNI CCHHHHHCCCCCCCE | 13.97 | 20377248 | |
| 760 | Phosphorylation | TKSCLTSTSGHTNIF CHHHHHCCCCCCCEE | 33.23 | 30377154 | |
| 770 | Phosphorylation | HTNIFHTSKETKQVS CCCEEECCCCCCCCC | 21.66 | 20377248 | |
| 777 | Phosphorylation | SKETKQVSDLDESTE CCCCCCCCCCCCCCC | 29.93 | 19823750 | |
| 782 | Phosphorylation | QVSDLDESTENVTFE CCCCCCCCCCCCEEE | 40.46 | 23749301 | |
| 783 | Phosphorylation | VSDLDESTENVTFEN CCCCCCCCCCCEEEC | 29.54 | 23749301 | |
| 787 | Phosphorylation | DESTENVTFENENTG CCCCCCCEEECCCCC | 36.49 | 21440633 | |
| 793 | Phosphorylation | VTFENENTGDENKNQ CEEECCCCCCCCCCC | 39.57 | 19795423 | |
| 810 | Phosphorylation | NFPGVANSTDKSTED CCCCCCCCCCCCCCC | 28.39 | 22369663 | |
| 811 | Phosphorylation | FPGVANSTDKSTEDN CCCCCCCCCCCCCCC | 47.45 | 22369663 | |
| 814 | Phosphorylation | VANSTDKSTEDNTDE CCCCCCCCCCCCCCC | 39.58 | 20377248 | |
| 815 | Phosphorylation | ANSTDKSTEDNTDEK CCCCCCCCCCCCCCH | 53.77 | 21440633 | |
| 819 | Phosphorylation | DKSTEDNTDEKYFSA CCCCCCCCCCHHEEE | 58.83 | 22369663 | |
| 823 | Phosphorylation | EDNTDEKYFSAINYT CCCCCCHHEEECCCC | 10.75 | 30377154 | |
| 829 | Phosphorylation | KYFSAINYTNVTGDS HHEEECCCCCCCCCC | 8.12 | 30377154 | |
| 830 | Phosphorylation | YFSAINYTNVTGDSS HEEECCCCCCCCCCC | 20.80 | 30377154 | |
| 833 | Phosphorylation | AINYTNVTGDSSCED ECCCCCCCCCCCHHH | 37.02 | 30377154 | |
| 837 | Phosphorylation | TNVTGDSSCEDIIET CCCCCCCCHHHHHHH | 26.68 | 30377154 | |
| 844 | Phosphorylation | SCEDIIETASNVEEN CHHHHHHHHCCHHHH | 25.61 | 30377154 | |
| 846 | Phosphorylation | EDIIETASNVEENLR HHHHHHHCCHHHHHH | 49.15 | 27214570 | |
| 865 | Phosphorylation | DMNEAEMSSGDECVK HCCHHHHHCCCCCEE | 23.75 | 22369663 | |
| 866 | Phosphorylation | MNEAEMSSGDECVKQ CCHHHHHCCCCCEEC | 49.29 | 22369663 | |
| 878 | Phosphorylation | VKQNDDGSKTQISFS EECCCCCCCEEEEEE | 39.25 | 19779198 | |
| 880 | Phosphorylation | QNDDGSKTQISFSTD CCCCCCCEEEEEECC | 32.60 | 22369663 | |
| 883 | Phosphorylation | DGSKTQISFSTDSPD CCCCEEEEEECCCCC | 11.88 | 22369663 | |
| 885 | Phosphorylation | SKTQISFSTDSPDNF CCEEEEEECCCCCCC | 25.23 | 20377248 | |
| 886 | Phosphorylation | KTQISFSTDSPDNFQ CEEEEEECCCCCCCC | 38.19 | 22369663 | |
| 888 | Phosphorylation | QISFSTDSPDNFQES EEEEECCCCCCCCCC | 33.95 | 22369663 | |
| 902 | Phosphorylation | SNDNTEFSSTKYKVR CCCCCCCCCCEEEEC | 30.76 | 27017623 | |
| 904 | Phosphorylation | DNTEFSSTKYKVRNS CCCCCCCCEEEECCC | 36.88 | 27017623 | |
| 911 | Phosphorylation | TKYKVRNSDLEDDES CEEEECCCCCCCCHH | 32.77 | 22369663 | |
| 918 | Phosphorylation | SDLEDDESLKKELTK CCCCCCHHHHHHHHH | 53.11 | 25521595 | |
| 937 | Phosphorylation | DKLDEEESEDSYEQD HHCCHHHCCCCCCCC | 50.40 | 22369663 | |
| 940 | Phosphorylation | DEEESEDSYEQDYAD CHHHCCCCCCCCCCC | 26.90 | 22369663 | |
| 941 | Phosphorylation | EEESEDSYEQDYADP HHHCCCCCCCCCCCC | 29.90 | 22369663 | |
| 945 | Phosphorylation | EDSYEQDYADPEPGN CCCCCCCCCCCCCCC | 16.76 | 19795423 | |
| 956 | Phosphorylation | EPGNDEGSNENIVKG CCCCCCCCCCCCCCC | 38.63 | 20377248 | |
| 1057 | Phosphorylation | NMEIPERSCVEKTHN CCCCCHHHHHHCCCC | 22.35 | 23749301 | |
| 1073 | Phosphorylation | VLFERRATTIENTKA HHHEECCHHHHHHHH | 26.88 | 17563356 | |
| 1074 | Phosphorylation | LFERRATTIENTKAL HHEECCHHHHHHHHH | 25.88 | 24961812 | |
| 1085 | Phosphorylation | TKALENNTNMHDQVS HHHHHCCCCHHHHHH | 45.56 | 29136822 | |
| 1092 | Phosphorylation | TNMHDQVSQACSDSD CCHHHHHHHHHCCCC | 13.36 | 20377248 | |
| 1096 | Phosphorylation | DQVSQACSDSDRDQD HHHHHHHCCCCCCCC | 43.07 | 19823750 | |
| 1098 | Phosphorylation | VSQACSDSDRDQDST HHHHHCCCCCCCCCC | 20.46 | 20377248 | |
| 1104 | Phosphorylation | DSDRDQDSTAEKNVE CCCCCCCCCCHHCCC | 24.71 | 20377248 | |
| 1105 | Phosphorylation | SDRDQDSTAEKNVEG CCCCCCCCCHHCCCH | 47.31 | 21440633 | |
| 1123 | Phosphorylation | HNLDIRVSSSEIESV HCCEEEEEHHHEEEC | 20.49 | 28889911 | |
| 1124 | Phosphorylation | NLDIRVSSSEIESVE CCEEEEEHHHEEECC | 29.18 | 23749301 | |
| 1125 | Phosphorylation | LDIRVSSSEIESVEP CEEEEEHHHEEECCC | 34.78 | 25752575 | |
| 1129 | Phosphorylation | VSSSEIESVEPLKPE EEHHHEEECCCCCCC | 37.12 | 23749301 | |
| 1137 | Phosphorylation | VEPLKPESDRSNIFS CCCCCCCCCCCCCCC | 47.02 | 17563356 | |
| 1140 | Phosphorylation | LKPESDRSNIFSSPI CCCCCCCCCCCCCCH | 38.99 | 23749301 | |
| 1144 | Phosphorylation | SDRSNIFSSPIRVIG CCCCCCCCCCHHHHH | 31.26 | 22369663 | |
| 1145 | Phosphorylation | DRSNIFSSPIRVIGA CCCCCCCCCHHHHHH | 17.38 | 22369663 | |
| 1155 | Acetylation | RVIGAVVKGVGKVVD HHHHHHHCCCCHHHH | 41.08 | 25381059 | |
| 1166 | Phosphorylation | KVVDVAESFVKKIDV HHHHHHHHHHHHCCC | 26.12 | 22369663 | |
| 1176 | Phosphorylation | KKIDVMDSESDDNVD HHCCCCCCCCCCCCC | 22.39 | 22369663 | |
| 1178 | Phosphorylation | IDVMDSESDDNVDIG CCCCCCCCCCCCCCC | 54.97 | 22369663 | |
| 1187 | Phosphorylation | DNVDIGDYNQDIFNK CCCCCCCCCHHHHHC | 14.98 | 22369663 | |
| 1195 | Phosphorylation | NQDIFNKSNSTDASV CHHHHHCCCCCCCCC | 36.80 | 22369663 | |
| 1197 | Phosphorylation | DIFNKSNSTDASVNM HHHHCCCCCCCCCCC | 34.45 | 22369663 | |
| 1198 | Phosphorylation | IFNKSNSTDASVNMK HHHCCCCCCCCCCCC | 39.57 | 22369663 | |
| 1201 | Phosphorylation | KSNSTDASVNMKSVS CCCCCCCCCCCCCCC | 19.48 | 23749301 | |
| 1206 | Phosphorylation | DASVNMKSVSSKERD CCCCCCCCCCCCCCC | 19.23 | 19823750 | |
| 1208 | Phosphorylation | SVNMKSVSSKERDSD CCCCCCCCCCCCCCC | 42.66 | 19823750 | |
| 1209 | Phosphorylation | VNMKSVSSKERDSDE CCCCCCCCCCCCCCH | 36.06 | 19823750 | |
| 1214 | Phosphorylation | VSSKERDSDEDEAVI CCCCCCCCCHHCEEE | 49.47 | 22369663 | |
| 1226 | Phosphorylation | AVILGGVTAEAHNDN EEEEECEEEEEECCC | 23.27 | 22369663 | |
| 1237 | Phosphorylation | HNDNGNNSRVINIDP ECCCCCCCCEEEECC | 31.74 | 22369663 | |
| 1245 | Phosphorylation | RVINIDPTTNGAYEE CEEEECCCCCCCCHH | 29.19 | 22369663 | |
| 1246 | Phosphorylation | VINIDPTTNGAYEED EEEECCCCCCCCHHC | 36.72 | 22369663 | |
| 1250 | Phosphorylation | DPTTNGAYEEDSEVF CCCCCCCCHHCHHHH | 22.65 | 29734811 | |
| 1254 | Phosphorylation | NGAYEEDSEVFRQQV CCCCHHCHHHHHHHH | 38.65 | 22369663 | |
| 1270 | Phosphorylation | DKENLHKSEEPLVEG CHHHCCCCCCCHHHH | 36.12 | 20377248 | |
| 1280 | Phosphorylation | PLVEGLQSEQHFEKK CHHHHHHHHHHHHCC | 44.24 | 27017623 | |
| 1290 | Phosphorylation | HFEKKDHSENEEEFD HHHCCCCCCCHHHHH | 52.85 | 22369663 | |
| 1298 | Phosphorylation | ENEEEFDTIYGDITS CCHHHHHHHHHCCHH | 22.78 | 22369663 | |
| 1300 | Phosphorylation | EEEFDTIYGDITSAN HHHHHHHHHCCHHCC | 15.73 | 22369663 | |
| 1304 | Phosphorylation | DTIYGDITSANIHSN HHHHHCCHHCCCCCC | 26.90 | 22369663 | |
| 1305 | Phosphorylation | TIYGDITSANIHSNA HHHHCCHHCCCCCCC | 21.47 | 22369663 | |
| 1310 | Phosphorylation | ITSANIHSNAPDDIK CHHCCCCCCCCCHHH | 30.78 | 22369663 | |
| 1326 | Phosphorylation | QQLLKNLSDLENYSQ HHHHHCHHHHCHHHH | 49.93 | 22369663 | |
| 1331 | Phosphorylation | NLSDLENYSQRLIED CHHHHCHHHHHHHHH | 9.23 | 21551504 | |
| 1332 | Phosphorylation | LSDLENYSQRLIEDS HHHHCHHHHHHHHHH | 22.02 | 22369663 | |
| 1339 | Phosphorylation | SQRLIEDSRRGKNQE HHHHHHHHHCCCCHH | 15.87 | 21440633 | |
| 1348 | Phosphorylation | RGKNQEESDEVNTSR CCCCHHHCCCCCHHH | 38.02 | 22369663 | |
| 1353 | Phosphorylation | EESDEVNTSRERDLT HHCCCCCHHHHHHCC | 34.04 | 22369663 | |
| 1354 | Phosphorylation | ESDEVNTSRERDLTF HCCCCCHHHHHHCCH | 27.26 | 22369663 | |
| 1360 | Phosphorylation | TSRERDLTFEKSVNE HHHHHHCCHHHHHCH | 33.75 | 22369663 | |
| 1364 | Phosphorylation | RDLTFEKSVNEKYAG HHCCHHHHHCHHHCC | 23.99 | 25704821 | |
| 1379 | Phosphorylation | AIEEDTFSELDISIQ CCCCCCCCEECEECC | 39.06 | 28132839 | |
| 1403 | Phosphorylation | LSNNQERSIEELNSE CCCCHHHCHHHHHCC | 33.33 | 22369663 | |
| 1409 | Phosphorylation | RSIEELNSEPEEAEL HCHHHHHCCHHHHHE | 68.13 | 22369663 | |
| 1445 | Phosphorylation | RQRGNIPSTDLPSDP HHCCCCCCCCCCCCC | 30.65 | 22369663 | |
| 1446 | Phosphorylation | QRGNIPSTDLPSDPP HCCCCCCCCCCCCCC | 35.88 | 22369663 | |
| 1450 | Phosphorylation | IPSTDLPSDPPSDKE CCCCCCCCCCCCCHH | 70.78 | 22369663 | |
| 1454 | Phosphorylation | DLPSDPPSDKEEVTD CCCCCCCCCHHHCCC | 67.70 | 22369663 | |
| 1460 | Phosphorylation | PSDKEEVTDSYPYSN CCCHHHCCCCCCCCC | 23.62 | 22369663 | |
| 1462 | Phosphorylation | DKEEVTDSYPYSNSE CHHHCCCCCCCCCCC | 20.74 | 21440633 | |
| 1463 | Phosphorylation | KEEVTDSYPYSNSEN HHHCCCCCCCCCCCC | 14.70 | 22369663 | |
| 1465 | Phosphorylation | EVTDSYPYSNSENIT HCCCCCCCCCCCCCC | 16.55 | 22369663 | |
| 1466 | Phosphorylation | VTDSYPYSNSENITA CCCCCCCCCCCCCCC | 29.40 | 22369663 | |
| 1468 | Phosphorylation | DSYPYSNSENITAEK CCCCCCCCCCCCCCC | 26.53 | 22369663 | |
| 1472 | Phosphorylation | YSNSENITAEKSAPT CCCCCCCCCCCCCCC | 40.10 | 22369663 | |
| 1476 | Phosphorylation | ENITAEKSAPTSPEV CCCCCCCCCCCCHHH | 30.87 | 21551504 | |
| 1479 | Phosphorylation | TAEKSAPTSPEVYEI CCCCCCCCCHHHHHH | 57.54 | 21440633 | |
| 1480 | Phosphorylation | AEKSAPTSPEVYEIF CCCCCCCCHHHHHHH | 20.29 | 20377248 | |
| 1484 | Phosphorylation | APTSPEVYEIFSDTP CCCCHHHHHHHCCCC | 11.14 | 20377248 | |
| 1488 | Phosphorylation | PEVYEIFSDTPNEVP HHHHHHHCCCCCCCC | 46.35 | 20377248 | |
| 1490 | Phosphorylation | VYEIFSDTPNEVPME HHHHHCCCCCCCCCC | 27.15 | 21551504 | |
| 1513 | Phosphorylation | TLEKHDKTNVTSVLD CCEECCCCCCEEHHC | 40.76 | 19779198 | |
| 1516 | Phosphorylation | KHDKTNVTSVLDDRS ECCCCCCEEHHCCCC | 18.39 | 19779198 | |
| 1517 | Phosphorylation | HDKTNVTSVLDDRSE CCCCCCEEHHCCCCH | 19.19 | 20377248 | |
| 1523 | Phosphorylation | TSVLDDRSEHLSSHD EEHHCCCCHHHHHCC | 36.04 | 21440633 | |
| 1527 | Phosphorylation | DDRSEHLSSHDVDNE CCCCHHHHHCCCCCC | 27.77 | 20377248 | |
| 1528 | Phosphorylation | DRSEHLSSHDVDNEP CCCHHHHHCCCCCCC | 30.02 | 21440633 | |
| 1539 | Phosphorylation | DNEPHDNSINIKVNE CCCCCCCCEEEEECC | 24.06 | 20377248 | |
| 1574 | Phosphorylation | QEEMPSKSVLEEQKP HHHCCCHHHHHHCCC | 35.95 | 19823750 | |
| 1582 | Phosphorylation | VLEEQKPSMELINDK HHHHCCCCHHHCCCC | 31.74 | 23749301 | |
| 1590 | Phosphorylation | MELINDKSSPENNND HHHCCCCCCCCCCCH | 54.73 | 19823750 | |
| 1591 | Phosphorylation | ELINDKSSPENNNDE HHCCCCCCCCCCCHH | 41.81 | 19823750 | |
| 1600 | Phosphorylation | ENNNDEETNREKDKT CCCCHHHHHHHHHHH | 37.21 | 20377248 | |
| 1626 | Acetylation | NSRRRKRKITEGSSA HHHHHHHHCCCCCHH | 57.95 | 25381059 | |
| 1628 | Phosphorylation | RRRKRKITEGSSAAS HHHHHHCCCCCHHHH | 37.01 | 21126336 | |
| 1638 | Acetylation | SSAASNTKRRRGHEP CHHHHHCCCCCCCCC | 48.43 | 25381059 | |
| 1647 | Phosphorylation | RRGHEPKSRGQNTHP CCCCCCCCCCCCCCC | 52.97 | 19779198 | |
| 1652 | Phosphorylation | PKSRGQNTHPSVDK- CCCCCCCCCCCCCC- | 27.55 | 19779198 | |
| 1655 | Phosphorylation | RGQNTHPSVDK---- CCCCCCCCCCC---- | 35.03 | 30377154 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ESC1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ESC1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ESC1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245; SER-442; THR-500;SER-532; SER-579; SER-662; SER-777; SER-865; SER-866; SER-883;SER-888; SER-911; SER-918; SER-937; SER-940; THR-1073; SER-1123;SER-1137; SER-1144; SER-1145; SER-1166; SER-1254; SER-1326; SER-1354;SER-1450 AND SER-1454, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532; SER-579; SER-583;SER-777; SER-911; SER-918; THR-1073; SER-1137; SER-1348; THR-1353 ANDSER-1354, AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; THR-732 ANDTHR-741, AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-532; SER-911 ANDSER-1326, AND MASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1145 AND SER-1326, ANDMASS SPECTROMETRY. | |
