| UniProt ID | NUP60_YEAST | |
|---|---|---|
| UniProt AC | P39705 | |
| Protein Name | Nucleoporin NUP60 | |
| Gene Name | NUP60 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 539 | |
| Subcellular Localization |
Nucleus, nuclear pore complex. Nucleus membrane Peripheral membrane protein Nucleoplasmic side. Nuclear basket. |
|
| Protein Description | Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).. | |
| Protein Sequence | MHRKSLRRASATVPSAPYRKQIISNAHNKPSLFSKIKTFFTQKDSARVSPRNNVANKQPRNESFNRRISSMPGGYFHSEISPDSTVNRSVVVSAVGEARNDIENKEEEYDETHETNISNAKLANFFSKKGNEPLSEIEIEGVMSLLQKSSKSMITSEGEQKSAEGNNIDQSLILKESGSTPISISNAPTFNPKYDTSNASMNTTLGSIGSRKYSFNYSSLPSPYKTTVYRYSAAKKIPDTYTANTSAQSIASAKSVRSGVSKSAPSKKISNTAAALVSLLDENDSKKNNAASELANPYSSYVSQIRKHKRVSPNAAPRQEISEEETTVKPLFQNVPEQGEEPMKQLNATKISPSAPSKDSFTKYKPARSSSLRSNVVVAETSPEKKDGGDKPPSSAFNFSFNTSRNVEPTENAYKSENAPSASSKEFNFTNLQAKPLVGKPKTELTKGDSTPVQPDLSVTPQKSSSKGFVFNSVQKKSRSNLSQENDNEGKHISASIDNDFSEEKAEEFDFNVPVVSKQLGNGLVDENKVEAFKSLYTF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MHRKSLRRASAT ---CCHHHHHHHHCC | 27.37 | 19795423 | |
| 10 | Phosphorylation | RKSLRRASATVPSAP HHHHHHHHCCCCCCH | 23.74 | 17330950 | |
| 12 | Phosphorylation | SLRRASATVPSAPYR HHHHHHCCCCCCHHH | 30.38 | 17330950 | |
| 15 | Phosphorylation | RASATVPSAPYRKQI HHHCCCCCCHHHHHH | 37.22 | 17287358 | |
| 18 | Phosphorylation | ATVPSAPYRKQIISN CCCCCCHHHHHHHHC | 30.11 | 22890988 | |
| 29 | Acetylation | IISNAHNKPSLFSKI HHHCCCCCHHHHHHH | 26.56 | 24489116 | |
| 35 | Acetylation | NKPSLFSKIKTFFTQ CCHHHHHHHHHHHCC | 40.67 | 24489116 | |
| 43 | Acetylation | IKTFFTQKDSARVSP HHHHHCCCCCCCCCC | 51.06 | 25381059 | |
| 45 | Phosphorylation | TFFTQKDSARVSPRN HHHCCCCCCCCCCCC | 25.63 | 27717283 | |
| 49 | Phosphorylation | QKDSARVSPRNNVAN CCCCCCCCCCCCCCC | 16.76 | 25521595 | |
| 57 | Acetylation | PRNNVANKQPRNESF CCCCCCCCCCCCHHH | 52.52 | 25381059 | |
| 63 | Phosphorylation | NKQPRNESFNRRISS CCCCCCHHHHHHHHC | 31.22 | 27017623 | |
| 69 | Phosphorylation | ESFNRRISSMPGGYF HHHHHHHHCCCCCCC | 20.83 | 22890988 | |
| 70 | Phosphorylation | SFNRRISSMPGGYFH HHHHHHHCCCCCCCC | 26.99 | 22890988 | |
| 75 | Phosphorylation | ISSMPGGYFHSEISP HHCCCCCCCCCCCCC | 12.20 | 22890988 | |
| 78 | Phosphorylation | MPGGYFHSEISPDST CCCCCCCCCCCCCCC | 27.08 | 22369663 | |
| 81 | Phosphorylation | GYFHSEISPDSTVNR CCCCCCCCCCCCCCH | 20.71 | 22369663 | |
| 84 | Phosphorylation | HSEISPDSTVNRSVV CCCCCCCCCCCHHHH | 37.32 | 22890988 | |
| 85 | Phosphorylation | SEISPDSTVNRSVVV CCCCCCCCCCHHHHH | 29.22 | 22890988 | |
| 89 | Phosphorylation | PDSTVNRSVVVSAVG CCCCCCHHHHHHHHH | 17.66 | 24909858 | |
| 93 | Phosphorylation | VNRSVVVSAVGEARN CCHHHHHHHHHHHHH | 12.96 | 25704821 | |
| 105 | Acetylation | ARNDIENKEEEYDET HHHHHCCCHHHCCHH | 54.43 | 24489116 | |
| 109 | Phosphorylation | IENKEEEYDETHETN HCCCHHHCCHHHHHH | 23.51 | 19779198 | |
| 112 | Phosphorylation | KEEEYDETHETNISN CHHHCCHHHHHHHCH | 23.32 | 22369663 | |
| 115 | Phosphorylation | EYDETHETNISNAKL HCCHHHHHHHCHHHH | 30.19 | 22369663 | |
| 118 | Phosphorylation | ETHETNISNAKLANF HHHHHHHCHHHHHHH | 32.57 | 22369663 | |
| 128 | Acetylation | KLANFFSKKGNEPLS HHHHHHHCCCCCCCC | 60.59 | 24489116 | |
| 135 | Phosphorylation | KKGNEPLSEIEIEGV CCCCCCCCHHHHHHH | 47.44 | 21440633 | |
| 151 | Acetylation | SLLQKSSKSMITSEG HHHHHHCCCCCCCCC | 51.65 | 25381059 | |
| 152 | Phosphorylation | LLQKSSKSMITSEGE HHHHHCCCCCCCCCH | 19.84 | 23749301 | |
| 155 | Phosphorylation | KSSKSMITSEGEQKS HHCCCCCCCCCHHHC | 16.45 | 30377154 | |
| 156 | Phosphorylation | SSKSMITSEGEQKSA HCCCCCCCCCHHHCC | 32.45 | 21440633 | |
| 161 | Ubiquitination | ITSEGEQKSAEGNNI CCCCCHHHCCCCCCC | 47.53 | 23749301 | |
| 162 | Phosphorylation | TSEGEQKSAEGNNID CCCCHHHCCCCCCCC | 31.11 | 22369663 | |
| 171 | Phosphorylation | EGNNIDQSLILKESG CCCCCCHHEEEEECC | 17.40 | 22369663 | |
| 177 | Phosphorylation | QSLILKESGSTPISI HHEEEEECCCCCEEE | 36.13 | 22369663 | |
| 179 | Phosphorylation | LILKESGSTPISISN EEEEECCCCCEEECC | 40.05 | 22369663 | |
| 180 | Phosphorylation | ILKESGSTPISISNA EEEECCCCCEEECCC | 28.32 | 22369663 | |
| 183 | Phosphorylation | ESGSTPISISNAPTF ECCCCCEEECCCCCC | 22.59 | 20377248 | |
| 185 | Phosphorylation | GSTPISISNAPTFNP CCCCEEECCCCCCCC | 21.83 | 22369663 | |
| 189 | Phosphorylation | ISISNAPTFNPKYDT EEECCCCCCCCCCCC | 33.36 | 22369663 | |
| 194 | Phosphorylation | APTFNPKYDTSNASM CCCCCCCCCCCCCCC | 26.22 | 20377248 | |
| 196 | Phosphorylation | TFNPKYDTSNASMNT CCCCCCCCCCCCCCC | 22.31 | 23749301 | |
| 197 | Phosphorylation | FNPKYDTSNASMNTT CCCCCCCCCCCCCCC | 27.74 | 21440633 | |
| 200 | Phosphorylation | KYDTSNASMNTTLGS CCCCCCCCCCCCCCC | 19.47 | 20377248 | |
| 203 | Phosphorylation | TSNASMNTTLGSIGS CCCCCCCCCCCCCCC | 18.11 | 21440633 | |
| 204 | Phosphorylation | SNASMNTTLGSIGSR CCCCCCCCCCCCCCC | 24.90 | 21551504 | |
| 207 | Phosphorylation | SMNTTLGSIGSRKYS CCCCCCCCCCCCEEE | 27.21 | 17563356 | |
| 210 | Phosphorylation | TTLGSIGSRKYSFNY CCCCCCCCCEEEECC | 24.75 | 19823750 | |
| 213 | Phosphorylation | GSIGSRKYSFNYSSL CCCCCCEEEECCCCC | 19.86 | 22369663 | |
| 214 | Phosphorylation | SIGSRKYSFNYSSLP CCCCCEEEECCCCCC | 15.28 | 22369663 | |
| 217 | Phosphorylation | SRKYSFNYSSLPSPY CCEEEECCCCCCCCC | 9.53 | 22369663 | |
| 218 | Phosphorylation | RKYSFNYSSLPSPYK CEEEECCCCCCCCCE | 26.88 | 22369663 | |
| 219 | Phosphorylation | KYSFNYSSLPSPYKT EEEECCCCCCCCCEE | 33.66 | 19823750 | |
| 222 | Phosphorylation | FNYSSLPSPYKTTVY ECCCCCCCCCEEEEE | 46.27 | 22369663 | |
| 224 | Phosphorylation | YSSLPSPYKTTVYRY CCCCCCCCEEEEEEC | 25.88 | 22369663 | |
| 232 | Phosphorylation | KTTVYRYSAAKKIPD EEEEEECCCCCCCCC | 16.86 | 19779198 | |
| 240 | Phosphorylation | AAKKIPDTYTANTSA CCCCCCCCEECCCCC | 19.88 | 22369663 | |
| 241 | Phosphorylation | AKKIPDTYTANTSAQ CCCCCCCEECCCCCH | 15.96 | 20377248 | |
| 242 | Phosphorylation | KKIPDTYTANTSAQS CCCCCCEECCCCCHH | 18.61 | 22369663 | |
| 245 | Phosphorylation | PDTYTANTSAQSIAS CCCEECCCCCHHHHH | 23.99 | 20377248 | |
| 246 | Phosphorylation | DTYTANTSAQSIASA CCEECCCCCHHHHHH | 24.90 | 22369663 | |
| 249 | Phosphorylation | TANTSAQSIASAKSV ECCCCCHHHHHHHHH | 21.60 | 22369663 | |
| 252 | Phosphorylation | TSAQSIASAKSVRSG CCCHHHHHHHHHHCC | 34.26 | 22369663 | |
| 278 | Phosphorylation | NTAAALVSLLDENDS HHHHHHHHHHCCCCH | 24.86 | 30377154 | |
| 300 | Phosphorylation | ELANPYSSYVSQIRK HHHCHHHHHHHHHHH | 24.58 | 17563356 | |
| 301 | Phosphorylation | LANPYSSYVSQIRKH HHCHHHHHHHHHHHC | 9.74 | 28889911 | |
| 312 | Phosphorylation | IRKHKRVSPNAAPRQ HHHCCCCCCCCCCCH | 19.23 | 19823750 | |
| 322 | Phosphorylation | AAPRQEISEEETTVK CCCCHHCCCCCCCHH | 37.90 | 17563356 | |
| 326 | Phosphorylation | QEISEEETTVKPLFQ HHCCCCCCCHHHHHH | 39.92 | 19823750 | |
| 327 | Phosphorylation | EISEEETTVKPLFQN HCCCCCCCHHHHHHC | 29.79 | 19823750 | |
| 349 | Phosphorylation | PMKQLNATKISPSAP CHHHHCCCCCCCCCC | 28.04 | 20377248 | |
| 352 | Phosphorylation | QLNATKISPSAPSKD HHCCCCCCCCCCCCC | 17.85 | 22369663 | |
| 354 | Phosphorylation | NATKISPSAPSKDSF CCCCCCCCCCCCCCC | 46.12 | 22369663 | |
| 357 | Phosphorylation | KISPSAPSKDSFTKY CCCCCCCCCCCCCCC | 49.14 | 22369663 | |
| 358 | Acetylation | ISPSAPSKDSFTKYK CCCCCCCCCCCCCCC | 57.23 | 24489116 | |
| 360 | Phosphorylation | PSAPSKDSFTKYKPA CCCCCCCCCCCCCCC | 38.25 | 21551504 | |
| 362 | Phosphorylation | APSKDSFTKYKPARS CCCCCCCCCCCCCCC | 37.10 | 29136822 | |
| 363 | Acetylation | PSKDSFTKYKPARSS CCCCCCCCCCCCCCC | 49.63 | 25381059 | |
| 364 | Phosphorylation | SKDSFTKYKPARSSS CCCCCCCCCCCCCCC | 21.10 | 19823750 | |
| 369 | Phosphorylation | TKYKPARSSSLRSNV CCCCCCCCCCCCCCE | 26.78 | 22369663 | |
| 370 | Phosphorylation | KYKPARSSSLRSNVV CCCCCCCCCCCCCEE | 28.04 | 22369663 | |
| 371 | Phosphorylation | YKPARSSSLRSNVVV CCCCCCCCCCCCEEE | 29.11 | 22369663 | |
| 374 | Phosphorylation | ARSSSLRSNVVVAET CCCCCCCCCEEEEEC | 38.99 | 22369663 | |
| 381 | Phosphorylation | SNVVVAETSPEKKDG CCEEEEECCCCCCCC | 39.58 | 22369663 | |
| 382 | Phosphorylation | NVVVAETSPEKKDGG CEEEEECCCCCCCCC | 23.67 | 22369663 | |
| 391 | Acetylation | EKKDGGDKPPSSAFN CCCCCCCCCCCCCCE | 63.20 | 24489116 | |
| 400 | Phosphorylation | PSSAFNFSFNTSRNV CCCCCEEEEECCCCC | 20.77 | 25752575 | |
| 403 | Phosphorylation | AFNFSFNTSRNVEPT CCEEEEECCCCCCCC | 27.36 | 30377154 | |
| 404 | Phosphorylation | FNFSFNTSRNVEPTE CEEEEECCCCCCCCC | 23.98 | 30377154 | |
| 416 | Phosphorylation | PTENAYKSENAPSAS CCCCCCCCCCCCCCC | 24.33 | 23749301 | |
| 423 | Phosphorylation | SENAPSASSKEFNFT CCCCCCCCCCCCCCC | 46.40 | 28889911 | |
| 424 | Phosphorylation | ENAPSASSKEFNFTN CCCCCCCCCCCCCCC | 35.60 | 30377154 | |
| 425 | Acetylation | NAPSASSKEFNFTNL CCCCCCCCCCCCCCC | 64.92 | 25381059 | |
| 430 | Phosphorylation | SSKEFNFTNLQAKPL CCCCCCCCCCCCCCC | 35.80 | 30377154 | |
| 435 | Acetylation | NFTNLQAKPLVGKPK CCCCCCCCCCCCCCC | 26.39 | 24489116 | |
| 443 | Phosphorylation | PLVGKPKTELTKGDS CCCCCCCCCCCCCCC | 44.76 | 29136822 | |
| 446 | Phosphorylation | GKPKTELTKGDSTPV CCCCCCCCCCCCCCC | 27.09 | 21440633 | |
| 447 | Acetylation | KPKTELTKGDSTPVQ CCCCCCCCCCCCCCC | 73.65 | 24489116 | |
| 450 | Phosphorylation | TELTKGDSTPVQPDL CCCCCCCCCCCCCCC | 43.19 | 22890988 | |
| 451 | Phosphorylation | ELTKGDSTPVQPDLS CCCCCCCCCCCCCCC | 32.02 | 22369663 | |
| 458 | Phosphorylation | TPVQPDLSVTPQKSS CCCCCCCCCCCCCCC | 31.18 | 22369663 | |
| 460 | Phosphorylation | VQPDLSVTPQKSSSK CCCCCCCCCCCCCCC | 19.34 | 22369663 | |
| 464 | Phosphorylation | LSVTPQKSSSKGFVF CCCCCCCCCCCCCCC | 34.30 | 30377154 | |
| 466 | Phosphorylation | VTPQKSSSKGFVFNS CCCCCCCCCCCCCHH | 43.84 | 28889911 | |
| 467 | Acetylation | TPQKSSSKGFVFNSV CCCCCCCCCCCCHHH | 59.31 | 24489116 | |
| 473 | Phosphorylation | SKGFVFNSVQKKSRS CCCCCCHHHHHHHHC | 17.92 | 22369663 | |
| 476 | Acetylation | FVFNSVQKKSRSNLS CCCHHHHHHHHCCCC | 51.03 | 25381059 | |
| 478 | Phosphorylation | FNSVQKKSRSNLSQE CHHHHHHHHCCCCCC | 48.23 | 25521595 | |
| 480 | Phosphorylation | SVQKKSRSNLSQEND HHHHHHHCCCCCCCC | 49.57 | 25521595 | |
| 483 | Phosphorylation | KKSRSNLSQENDNEG HHHHCCCCCCCCCCC | 39.43 | 25521595 | |
| 502 | Phosphorylation | ASIDNDFSEEKAEEF EEECCCCCHHHHHHC | 47.94 | 29650682 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 360 | S | Phosphorylation | Kinase | CHEK2 | - | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NUP60_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NUP60_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-81; SER-162;SER-219; SER-312; SER-352; SER-360; THR-381; SER-382; THR-460;SER-478; SER-480 AND SER-483, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; SER-81; SER-185;SER-207; SER-300; SER-312; SER-322; SER-352; SER-360; THR-381;SER-382; SER-400; THR-460; SER-473; SER-480 AND SER-483, AND MASSSPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-15; SER-49;SER-360; SER-369; SER-374; THR-381; SER-382; SER-480 AND SER-483, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10 AND SER-81, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-382, AND MASSSPECTROMETRY. | |
