| UniProt ID | MID1_YEAST | |
|---|---|---|
| UniProt AC | P41821 | |
| Protein Name | Stretch-activated cation channel MID1 | |
| Gene Name | MID1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 548 | |
| Subcellular Localization |
Cell membrane. Endoplasmic reticulum. Membrane Single-pass type I membrane protein . Trafficking to the plasma membrane is dependent on the N-glycosylation and the transporter protein SEC12. |
|
| Protein Description | Calcium-permeable, cation-selective stretch-activated channel (SAC). Required for calcium influx and for vitality of MATa cells in a late, pheromone-induced event of the mating process requiring calcium induced signaling. Functions together with CCH1 to ensure that adequate levels of Ca(2+) are supplied to PMR1 to sustain secretion and growth. Required for growth in low-calcium environments. Together with CCH1, essential for tolerance to iron stress, which leads to an increased oxidative poise, and to cold stress.. | |
| Protein Sequence | MIVWQALFVVYCLFTTSIHGLFQDFNPFANKNISLKFPSLNRWEKNVMATGQQTIINSDSIYEWTPILSNITAGKKDSFVFTIDAEASGYGFAPTYEVLMFISGNICQMPMNRSDVDLTIYYSFNETVLENPNIGQSAVFQDGYIQALAISPVQSSSSNATSTYSNLYVVAELVNSTTEQPLSSSDASENWEYRLSISENDLVFQWDVRPWVEVLDTDMNSALLSTGNVTADAKVYHNYSIYDPSLYDLYVYSYEDSVQLNQNYNLSLCAVKNGPYLVSSQNTSNATVTSNSTNPLERTDLAIQKKITEYGGSVTEMFYVTGLNASTTYVAYLTKKISNGDGLSSVGGILFSHVYFTTRSTDVCSLIFGLDFCSDVAYSVPTSSFSVGNKTLMAQTYDHIAEALYANFSKALQLISCDADKDARYSPVMTCDDCAEAYRDWVCAVSIPRCTTTSSQYYIHRDKSHNRNDYLNKFIKPLDDYYEILPCIDMCYTLVRNCPSDFQFSCPNDLTTEDLLYQSYNFYMDTDYSTCNYIGNSSLMVIHPLDDT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 32 | N-linked_Glycosylation | FNPFANKNISLKFPS CCCCCCCCCEEECCC | 28.96 | - | |
| 34 | Phosphorylation | PFANKNISLKFPSLN CCCCCCCEEECCCCC | 34.59 | 15665377 | |
| 70 | N-linked_Glycosylation | EWTPILSNITAGKKD EECCCHHHCCCCCCC | 31.98 | - | |
| 112 | N-linked_Glycosylation | NICQMPMNRSDVDLT CCCCCCCCCCCCCEE | 34.14 | - | |
| 125 | N-linked_Glycosylation | LTIYYSFNETVLENP EEEEEECCCEECCCC | 37.78 | - | |
| 159 | N-linked_Glycosylation | PVQSSSSNATSTYSN CCCCCCCCCCCCCCH | 49.54 | - | |
| 175 | N-linked_Glycosylation | YVVAELVNSTTEQPL HHEEEHHCCCCCCCC | 46.38 | - | |
| 228 | N-linked_Glycosylation | SALLSTGNVTADAKV CCCHHCCCEECCCEE | 28.23 | - | |
| 238 | N-linked_Glycosylation | ADAKVYHNYSIYDPS CCCEEECCCCCCCCH | 17.98 | - | |
| 265 | N-linked_Glycosylation | VQLNQNYNLSLCAVK EEECCCCCEEEEEEE | 30.61 | - | |
| 282 | N-linked_Glycosylation | PYLVSSQNTSNATVT CEEEECCCCCCCEEE | 47.63 | - | |
| 285 | N-linked_Glycosylation | VSSQNTSNATVTSNS EECCCCCCCEEECCC | 37.28 | - | |
| 291 | N-linked_Glycosylation | SNATVTSNSTNPLER CCCEEECCCCCCCCC | 43.41 | - | |
| 324 | N-linked_Glycosylation | MFYVTGLNASTTYVA EEEECCCCCCCEEEE | 32.94 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MID1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MID1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MID1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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