dbPTM

CAX4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CAX4_YEAST
UniProt AC	P53223
Protein Name	Dolichyldiphosphatase
Gene Name	CAX4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	239
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Non-essential protein which is required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate..
Protein Sequence	MNSTAAAINPNPNVIPFDDTYILYDSHDFLSFLSAYFSLMPILVLAFYLSWFIITRELEACIVAFGQLMNEIFNNVIKNIIKQPRPVSFGASFQNDTIRSGYGMPSAHSQFMGFCFTYNSLKIYTSWKNLNFLEKCIFSGALALLSFCVCFSRVYLHYHNLDQVIVGFSVGALTGSLYFFIVGIIRELGLINWFLKLRIVRLFYMTDSYNLAPLTLKENYEAYWKRINQRSFNDKSKRD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of CAX4_YEAST !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CAX4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CAX4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CAX4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGP1_YEAST	RGP1	genetic	16269340
RIC1_YEAST	RIC1	genetic	16269340
MTC1_YEAST	MTC1	genetic	16269340
ERG4_YEAST	ERG4	genetic	16269340
FUS3_YEAST	FUS3	genetic	19269370
KPC1_YEAST	PKC1	genetic	19269370
ATG14_YEAST	ATG14	genetic	19269370
PPZ2_YEAST	PPZ2	genetic	19269370
CAK1_YEAST	CAK1	genetic	19269370
KC11_YEAST	YCK1	genetic	19269370
TOR1_YEAST	TOR1	genetic	19269370
ELM1_YEAST	ELM1	genetic	19269370
RIC1_YEAST	RIC1	genetic	19269370
GLC8_YEAST	GLC8	genetic	19269370
MSG5_YEAST	MSG5	genetic	19269370
INP53_YEAST	INP53	genetic	19269370
SEC59_YEAST	SEC59	genetic	27524515
PFF1_YEAST	PFF1	genetic	27708008
RGD1_YEAST	RGD1	genetic	27708008
STE50_YEAST	STE50	genetic	27708008
MNN10_YEAST	MNN10	genetic	27708008
LPP1_YEAST	LPP1	genetic	27708008
HAC1_YEAST	HAC1	genetic	27708008
RIM15_YEAST	RIM15	genetic	27708008
SKN1_YEAST	SKN1	genetic	27708008
SLT2_YEAST	SLT2	genetic	27708008
BCK1_YEAST	BCK1	genetic	27708008
STE24_YEAST	STE24	genetic	27708008
CANB_YEAST	CNB1	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
COG6_YEAST	COG6	genetic	27708008
FAR11_YEAST	FAR11	genetic	27708008
SRO7_YEAST	SRO7	genetic	27708008
AXL1_YEAST	AXL1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CAX4_YEAST

Related Literatures of Post-Translational Modification