AXL1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AXL1_YEAST
• UniProt AC: P40851
• Protein Name: Putative protease AXL1
• Gene Name: AXL1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1208
• Subcellular Localization: Bud neck . Mother-bud neck and division site remnants of haploid cells.
• Protein Description: Probable protease. Involved in axial budding..
• Protein Sequence: MSLREVTNYEVSFYIPLSYSNRTHKVCKLPNGILALIISDPTDTSSSCSLTVCTGSHNDPKDIAGLAHLCEHMILSAGSKKYPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLFNPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKKIKLKSSLNTYFENNFFGENITLCIRGPQSVNILTKLALSKFGDIKPKSAVKERSISIRTRSFRRSKSLKKRQDSSKNDYSDLKTFKILNTTWEKKYKNTMCFQQFPECNSIFINSNKVPIMRLLFPVSDKNTRFTKDDIKIYSHLWCELFGDESPGSLSYYLASKGWLTGCFAFTSEFAIGDIGLILELELTNSGWENIKRITTIVLNRLLPSFYVMNIDYLITFLKEQNLIDLVSFLYQSSEDLPMEECSKLSGILQDDLECLTPPNIFKGFKSLIEIDDPNIEKYENTKANIQWWTGQAIKFQNFLKSFMNHDNMRLLLLGNIKSGNIFDKMKNKSDICTDFFYEFEYYTANVHLASDNKFHSNSSYEFNFPTGNLFLPDCVSDPLKLQQLFLECSLKSKFATLRPQIYSEPTRTKPQLVSENQNYEMWILKEDPNFASDNKSVVSFEVLGLGIKPSPEATIHLEVLAQALFIITSSFLYPALRIGYTYEIASSSKGNVTLRFTISGFPEGVFTIVKTFVDTLKLIATDPTFLSKDTLRKARILVRNKYKNASSDNCVKLASVGLLIVLEKYIWTLEDRINALELTELESFEKFCFLFWRNPKHLVLFMQGSLEYADAINRYLNNNFTQHLKISNEGSKPTIRLYPPPSTKDLDQGTNAFISYNGHQDDPNNSIVYFIQTAQRDDIKNLTLTFLTEYLFSLTLVPDLRNKKQIGYIVLGGLRVLTDTVGIHITVMSGSSGHNLETRINEYLSYLQLQVLNRFTEFDFRRILLEPFLNLLKQNSTKQFEGSAGPVDLLNEIVANVQNGDNYTLNNKQMRQHRKVRNKIAEGRLNFQEDHEMIDISFLQKLTLKKYLAFFESKISIYSAQRSKLSIMITSPMAEKEIASRKMFLQLEAFLKINGFAIKNEDLKKIVEHSKGNPILLVKNLFTYFRRRNEVFKLGTVVLQEILKIIGMNLKQRYGSILGFSSQDGEGQEIEKFWNNDTSPIVPLQELPEPNFFRKAAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
200	Ubiquitination	LSSIPQLKKIKLKSS CCCCCCCCCCEECHH	47.40	17644757
201	Ubiquitination	SSIPQLKKIKLKSSL CCCCCCCCCEECHHH	54.38	17644757
262	Phosphorylation	SISIRTRSFRRSKSL CEEEEHHHHHCCCCH	23.61	17287358
404	Phosphorylation	WENIKRITTIVLNRL HHHHHHHHHHHHHHH	17.95	28889911
405	Phosphorylation	ENIKRITTIVLNRLL HHHHHHHHHHHHHHC	13.50	28889911
453	Ubiquitination	LPMEECSKLSGILQD CCHHHHHHHCCCCHH	59.33	17644757
472	Ubiquitination	LTPPNIFKGFKSLIE CCCCCHHHCCHHHEE	60.69	17644757
475	Ubiquitination	PNIFKGFKSLIEIDD CCHHHCCHHHEECCC	53.68	17644757
487	Ubiquitination	IDDPNIEKYENTKAN CCCCCHHHHCCCCCE	54.81	17644757
492	Ubiquitination	IEKYENTKANIQWWT HHHHCCCCCEEECHH	51.52	17644757
504	Ubiquitination	WWTGQAIKFQNFLKS CHHHHHHHHHHHHHH	43.86	17644757
603	Ubiquitination	LECSLKSKFATLRPQ HHHHHHHHHHHCCCH	37.11	24961812
842	Ubiquitination	KISNEGSKPTIRLYP EECCCCCCCEEEEEC	57.97	23749301
848	Phosphorylation	SKPTIRLYPPPSTKD CCCEEEEECCCCCCC	12.12	28132839
893	Phosphorylation	RDDIKNLTLTFLTEY CCCCHHCHHHHHHHH	32.90	27214570
895	Phosphorylation	DIKNLTLTFLTEYLF CCHHCHHHHHHHHHH	16.03	27214570
903	Phosphorylation	FLTEYLFSLTLVPDL HHHHHHHHCCCCCCC	20.18	27214570
1076	Phosphorylation	SAQRSKLSIMITSPM HHCCCCEEEEEECCC	17.53	28889911
1134	Phosphorylation	LVKNLFTYFRRRNEV EECCHHHHHHHHCCH	6.43	21126336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AXL1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AXL1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AXL1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BUD4_YEAST	BUD4	physical	12176366
BUD5_YEAST	BUD5	physical	12176366
FUS1_YEAST	FUS1	genetic	9744878
RAX1_YEAST	RAX1	genetic	14980713
MFA1_YEAST	MFA1	genetic	8991086
BUD4_YEAST	BUD4	physical	22553209
BUD4_YEAST	BUD4	physical	25002677

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262, AND MASSSPECTROMETRY.
PubMed: 17287358