RAX1_YEAST - dbPTM
RAX1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAX1_YEAST
UniProt AC Q08760
Protein Name Bud site selection protein RAX1
Gene Name RAX1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 435
Subcellular Localization Cell membrane
Multi-pass membrane protein. Bud neck. Bud tip. Before cytokinesis, RAX1 concentrates as a ring at the mother-bud neck and to the tip of the bud. The RAX1 ring splits at cytokinesis, endowing each progeny cell with a RAX1 ring and addi
Protein Description Required for the establishment of the bipolar budding pattern. Involved in selecting bud sites at both the distal and proximal poles of daughter cells as well as near previously used division sites on mother cells. Has a role in the localization of BUD8, the distal bipolar budding landmark, and of BUD9, the proximal pole landmark..
Protein Sequence MKEELSKVSSMQNFEMIQRERLPTLYEVLIQRTSQPVDLWTFYTFLSQFPYAINYLDFWVDLMTHTRLCKNYIELVRKSLINFPQEQQQNGSTSTATFDLLNALIEEGHLDPEAPDKLLENSGPDVPFSPKLNELLGDWKHQSGIGQEALRNEDVALIVDEIMKRRSQQDGKPQITTKQLLHSAVGLCNTYLVSPEQSERYLSNIPMETRNRIIESVQIERKYDIEIFDDLKNLTYQFLEMDCFPKFLSRVALHNIHDEISDWRFHSVGVTNEKSNRSRGQTHISRSPFSNHTSISRIGFGLLWLGIGFWIGYVLIFLAYSRAIRVVTVVPFTLGCYCIVCGMYQVDIVYSWFGVTQRLLHRHKNAGNDEGDASSDTDHVPMILAVFGGRRRLTRIEHPFTRQLLRKRGLWCLLLVVGATAAFTVIFSCVPGRRV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Ubiquitination------MKEELSKVS
------CHHHHHHHH		60.9523749301
9PhosphorylationKEELSKVSSMQNFEM
HHHHHHHHHHHHHHH		24.6728152593
10PhosphorylationEELSKVSSMQNFEMI
HHHHHHHHHHHHHHH		27.6324930733
79PhosphorylationYIELVRKSLINFPQE
HHHHHHHHHHCCCHH		24.7421440633
122PhosphorylationPDKLLENSGPDVPFS
CHHHHHCCCCCCCCC		42.1821551504
129PhosphorylationSGPDVPFSPKLNELL
CCCCCCCCHHHHHHH		18.3028889911
140UbiquitinationNELLGDWKHQSGIGQ
HHHHCCHHCCCCCCH		36.1823749301
167PhosphorylationDEIMKRRSQQDGKPQ
HHHHHHHHCCCCCCC		35.9121551504
172UbiquitinationRRSQQDGKPQITTKQ
HHHCCCCCCCCCHHH		41.8823749301
274UbiquitinationSVGVTNEKSNRSRGQ
EECCCCCCCCCCCCC		55.9123749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAX1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAX1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAX1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAX2_YEASTRAX2physical
15356260
BUD8_YEASTBUD8physical
15356260
BUD9_YEASTBUD9physical
15356260
BUD8_YEASTBUD8physical
17581861
BUD9_YEASTBUD9physical
17581861
SEI1_YEASTFLD1physical
18719252
ERP2_YEASTERP2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
SEA4_YEASTSEA4genetic
27708008
HNM1_YEASTHNM1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
RS25A_YEASTRPS25Agenetic
27708008
GOSR1_YEASTGOS1genetic
27708008
RIR3_YEASTRNR3genetic
27708008
NUC1_YEASTNUC1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
EMC2_YEASTEMC2genetic
27708008
IRS4_YEASTIRS4genetic
27708008
FPS1_YEASTFPS1genetic
27708008
ENV10_YEASTENV10genetic
27708008
PYRC_YEASTURA4genetic
27708008
AEP2_YEASTAEP2genetic
27708008
HDA1_YEASTHDA1genetic
27708008
SWS2_YEASTSWS2genetic
27708008
LSM7_YEASTLSM7genetic
27708008
TLG2_YEASTTLG2genetic
27708008
BUB3_YEASTBUB3genetic
27708008
HIR2_YEASTHIR2genetic
27708008
RAD1_YEASTRAD1genetic
27708008
POC4_YEASTPOC4genetic
27708008
COX10_YEASTCOX10genetic
27708008
WHI5_YEASTWHI5genetic
29074565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAX1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167, AND MASSSPECTROMETRY.

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