| UniProt ID | SEA4_YEAST | |
|---|---|---|
| UniProt AC | P38164 | |
| Protein Name | SEH-associated protein 4 | |
| Gene Name | SEA4 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1038 | |
| Subcellular Localization |
Cytoplasm. Vacuole membrane Peripheral membrane protein. |
|
| Protein Description | Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis.. | |
| Protein Sequence | MGLIKKVTHWSYDNLIDYLSVNPTRDEVTHYKVDPENESDESIIKLHTVKDFGSITCLDYSESEIGMIGVGEKNGYLRIFNISGQNSSSPASHAPVGLNANNETSMTNASGGKAAQAENIVGSVSNLKDTQGYPVSETNYDIRVRAKKQRCINSLGINTNGLIAMGLDRNKHDSSLQIWDMNYHDDSHETINPMFSYCTNESIVSLKFLNDTSVLAASTKFLKEIDVRSPNPIYQHPTRLTYDIKLNPFNDWQFSTYGDDGTLAIWDRRKLSDQASLGDLNVASPLLTFEKLVGSGAASRKYMNSCFRWSCVRNNEFATLHRGDTIKRWRLGYYCDSNRDIAADDDNEMNIENLFVSSVHDTNTMYDRVATFDYIPRSNNGTSLICMRQSGTIYRMPISEVCSKAILNNRNSLLLSNFENTEIDEIRVNNEHEKSNLENVKTILKNLSFEDLDVSEDYFPSGHDEPNNEIEYSELSEEENEGSNDVLDSKRGFELFWKPEKLLEKDISVIMRTRASLGYGLDPMNTVEMIDSSKNLQNNAYIRNTWRWIAIAKASVDDGTMVSGDLDLGYEGVIGIWNGINGISNQDRYRQETILSDKQLNKEMEKIIKLRRKNRDRNSPIANAAGSPKYVQRRLCLIISGWDLSRSDYEDKYNIIMKNGHYEKAAAWAVFFGDIPKAVEILGSAKKERLRLIATAIAGYLAYKDLPGNNAWRQQCRKMSSELDDPYLRVIFAFIADNDWWDILYEPAISLRERLGVALRFLNDTDLTTFLDRTSSTVIENGELEGLILTGITPNGIDLLQSYVNKTSDVQSAALISIFGSPRYFRDQRVDEWIQTYRDMLKSWELFSMRARFDVLRSKLSRTKTGVLTADIKPRQIYIQCQNCKQNINTPRTSSPSSAVSTSAGNYKNGEAYRRNNADYKKFNTGSSEAQAADEKPRHKYCCPHCGSSFPRCAICLMPLGTSNLPFVINGTQSRDPMQTEDSQDGANRELVSRKLKLNEWFSFCLSCNHGMHAGHAEEWFDRHNVCPTPGCTCQCNK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 83 | Phosphorylation | YLRIFNISGQNSSSP EEEEEEECCCCCCCC | 19779198 | ||
| 87 | Phosphorylation | FNISGQNSSSPASHA EEECCCCCCCCCCCC | 19779198 | ||
| 89 | Phosphorylation | ISGQNSSSPASHAPV ECCCCCCCCCCCCCC | 23749301 | ||
| 110 | Phosphorylation | ETSMTNASGGKAAQA CCCCCCCCCCHHHHH | 23749301 | ||
| 123 | Phosphorylation | QAENIVGSVSNLKDT HHHHHCEEHHCCCCC | 22369663 | ||
| 125 | Phosphorylation | ENIVGSVSNLKDTQG HHHCEEHHCCCCCCC | 21440633 | ||
| 133 | Phosphorylation | NLKDTQGYPVSETNY CCCCCCCCCCCCCCC | 23749301 | ||
| 136 | Phosphorylation | DTQGYPVSETNYDIR CCCCCCCCCCCCEEH | 27214570 | ||
| 138 | Phosphorylation | QGYPVSETNYDIRVR CCCCCCCCCCEEHHH | 27214570 | ||
| 378 | Phosphorylation | TFDYIPRSNNGTSLI ECEEECCCCCCCEEE | 28889911 | ||
| 383 | Phosphorylation | PRSNNGTSLICMRQS CCCCCCCEEEEEECC | 28889911 | ||
| 412 | Phosphorylation | AILNNRNSLLLSNFE HHHCCCCCEEHHCCC | 30377154 | ||
| 476 | Phosphorylation | EIEYSELSEEENEGS CCCHHHCCHHHCCCC | 27214570 | ||
| 508 | Phosphorylation | KLLEKDISVIMRTRA HHHHCCHHHHHHCHH | 21440633 | ||
| 619 | Phosphorylation | RKNRDRNSPIANAAG HHCCCCCCCCCCCCC | 27214570 | ||
| 695 | Phosphorylation | ERLRLIATAIAGYLA HHHHHHHHHHHHHHH | 21440633 | ||
| 861 | Phosphorylation | DVLRSKLSRTKTGVL HHHHHHHCCCCCCEE | 21551504 | ||
| 863 | Phosphorylation | LRSKLSRTKTGVLTA HHHHHCCCCCCEEEC | 21551504 | ||
| 865 | Phosphorylation | SKLSRTKTGVLTADI HHHCCCCCCEEECCC | 28889911 | ||
| 893 | Phosphorylation | QNINTPRTSSPSSAV CCCCCCCCCCCCCCC | 22369663 | ||
| 894 | Phosphorylation | NINTPRTSSPSSAVS CCCCCCCCCCCCCCC | 22369663 | ||
| 895 | Phosphorylation | INTPRTSSPSSAVST CCCCCCCCCCCCCCC | 22369663 | ||
| 897 | Phosphorylation | TPRTSSPSSAVSTSA CCCCCCCCCCCCCCC | 21440633 | ||
| 898 | Phosphorylation | PRTSSPSSAVSTSAG CCCCCCCCCCCCCCC | 22369663 | ||
| 901 | Phosphorylation | SSPSSAVSTSAGNYK CCCCCCCCCCCCCCC | 22369663 | ||
| 902 | Phosphorylation | SPSSAVSTSAGNYKN CCCCCCCCCCCCCCC | 22369663 | ||
| 903 | Phosphorylation | PSSAVSTSAGNYKNG CCCCCCCCCCCCCCC | 22369663 | ||
| 913 | Phosphorylation | NYKNGEAYRRNNADY CCCCCHHHHHCCCCC | 27017623 | ||
| 925 | Phosphorylation | ADYKKFNTGSSEAQA CCCHHCCCCCHHHHH | 29136822 | ||
| 927 | Phosphorylation | YKKFNTGSSEAQAAD CHHCCCCCHHHHHCC | 29136822 | ||
| 928 | Phosphorylation | KKFNTGSSEAQAADE HHCCCCCHHHHHCCC | 29136822 | ||
| 980 | Phosphorylation | QSRDPMQTEDSQDGA CCCCCCCCCCCCCCH | 30377154 | ||
| 983 | Phosphorylation | DPMQTEDSQDGANRE CCCCCCCCCCCHHHH | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEA4_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEA4_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEA4_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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