| UniProt ID | KA120_YEAST | |
|---|---|---|
| UniProt AC | Q02932 | |
| Protein Name | Importin beta-like protein KAP120 | |
| Gene Name | KAP120 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1032 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, RAN-dependent mechanism. Required for nuclear import of Ho endonuclease and RFP1, and involved in rRNA-processing and assembly or export of 60S ribosomal subunits.. | |
| Protein Sequence | MASSLNELNLVQVLEQASNPQHIRSDVQKLAEQQLRQWETQAGFHYLLQSIYLNLSNSLQIRWLAVIQFKNGVDKYWRSTRINAIPKDEKASIRGRLFEMIDEQNNQLCIQNAQASARIARLDFPVEWPTLFEDLENLLNDEIIRKDSVKIYNILMHINQIVKVLGTARIGRCRPAMQSKVPLILPLIVRIYLQSFEEWTTSSNLNYEDLSSLQVSYLALKVLRRIICEGYDRPQTDQSVCDFIKLSVSHFEMLISNHENFKKFDIYEKFIKCLGKLYFNLVTGSPANFILLPCSTQILITYTRLIFDKAPKVYRENSDVTGDFWEQTAIRGLLILKRVINFIHKKGAITLKARSDKLTIDASINKINTEFLNENLITRLVDTLMEWYLRLRPTELENWFMDPEEWINEQMATSYEYQIRPCAENVFQDLMNTFSELLVPYLLKKIENDASKLSNSLDDFLRKDAIYASFQLSASAVSEMVDFDRLLIQVFLPEATNTNISGDELRIIRRRVALIINEWSTVKCSEESKSLCYKLFTNFLTDEDDKVVLLTTVQTVRTMVDDWNFNKDTFQPFLTENVHLLLRKILPSVSLTETRLYVLNTLSDIIIQTKPLISRDLLVEILQIIPNLWEIATNNASEAILANALLRLLRNLVSSLGSQSHLTWDIAIPVVALACDPSSMQYQLLSEDGYELWGMLLQNFSSHDQEFDDKFVELVPFLKYGIETHTEILPTLLEIIKSYALILNPVDFFSNNTFQDIFKQMSKYLLKLREDSFQLVLEIWEILILSNESDYENLLLQKFYETGVLSALFDAIFLEEAPSSYLCSQIIQIIARISYVNPDALMTFLATYHDNLPTSNENARMPESIRKIVSKDQTYDSVVNKLLTGWIVCFRDIFDPKFKKVHILGISSLLRTGLVPILTEFSSIASLWIEMLEEINETNRGDCEKYHLNDIVTEQSIAFHPLTAEQLRYHQLCKNNDPVHNISLKDFISQSMEYLESHLGVERYQEFLKTINPSLLENLQMFLSIQPQEARP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASSLNELN ------CCCCHHHHC | 21.09 | 22814378 | |
| 29 | Acetylation | HIRSDVQKLAEQQLR HHHHHHHHHHHHHHH | 49.89 | 24489116 | |
| 278 | Phosphorylation | IKCLGKLYFNLVTGS HHHHHHHHHHHHHCC | 8.23 | 28132839 | |
| 302 | Phosphorylation | STQILITYTRLIFDK CCHHHHHHHHHHHCC | 5.27 | 28132839 | |
| 309 | Acetylation | YTRLIFDKAPKVYRE HHHHHHCCCCCCCCC | 56.70 | 24489116 | |
| 871 | Acetylation | SIRKIVSKDQTYDSV HHHHHHCCCCCHHHH | 42.85 | 24489116 | |
| 983 | Phosphorylation | NDPVHNISLKDFISQ CCCCCCCCHHHHHHH | 34.38 | 15665377 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of KA120_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KA120_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KA120_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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