IF4A_YEAST - dbPTM
IF4A_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IF4A_YEAST
UniProt AC P10081
Protein Name ATP-dependent RNA helicase eIF4A
Gene Name TIF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 395
Subcellular Localization Cytoplasm .
Protein Description ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon..
Protein Sequence MSEGITDIEESQIQTNYDKVVYKFDDMELDENLLRGVFGYGFEEPSAIQQRAIMPIIEGHDVLAQAQSGTGKTGTFSIAALQRIDTSVKAPQALMLAPTRELALQIQKVVMALAFHMDIKVHACIGGTSFVEDAEGLRDAQIVVGTPGRVFDNIQRRRFRTDKIKMFILDEADEMLSSGFKEQIYQIFTLLPPTTQVVLLSATMPNDVLEVTTKFMRNPVRILVKKDELTLEGIKQFYVNVEEEEYKYECLTDLYDSISVTQAVIFCNTRRKVEELTTKLRNDKFTVSAIYSDLPQQERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPANKENYIHRIGRGGRFGRKGVAINFVTNEDVGAMRELEKFYSTQIEELPSDIATLLN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSEGITDIE
------CCCCCCHHH		44.5222369663
2Acetylation------MSEGITDIE
------CCCCCCHHH		44.529298649
6Phosphorylation--MSEGITDIEESQI
--CCCCCCHHHHHHH		41.6122369663
11PhosphorylationGITDIEESQIQTNYD
CCCHHHHHHHHCCCC		21.5724909858
15PhosphorylationIEESQIQTNYDKVVY
HHHHHHHCCCCEEEE		37.0629136822
17PhosphorylationESQIQTNYDKVVYKF
HHHHHCCCCEEEEEE		22.1129136822
23AcetylationNYDKVVYKFDDMELD
CCCEEEEEECCCCCC		30.6124489116
23SuccinylationNYDKVVYKFDDMELD
CCCEEEEEECCCCCC		30.6123954790
68PhosphorylationDVLAQAQSGTGKTGT
EEEEECCCCCCCCCE		41.1425752575
70PhosphorylationLAQAQSGTGKTGTFS
EEECCCCCCCCCEEE		40.5328152593
73PhosphorylationAQSGTGKTGTFSIAA
CCCCCCCCCEEEHHH		42.6828889911
75PhosphorylationSGTGKTGTFSIAALQ
CCCCCCCEEEHHHHH		21.3119779198
77PhosphorylationTGKTGTFSIAALQRI
CCCCCEEEHHHHHHC		15.9128152593
86PhosphorylationAALQRIDTSVKAPQA
HHHHHCCCCCCCCCH		32.8021440633
87PhosphorylationALQRIDTSVKAPQAL
HHHHCCCCCCCCCHH		20.2028889911
89AcetylationQRIDTSVKAPQALML
HHCCCCCCCCCHHHC		54.8624489116
89SuccinylationQRIDTSVKAPQALML
HHCCCCCCCCCHHHC		54.8623954790
89UbiquitinationQRIDTSVKAPQALML
HHCCCCCCCCCHHHC		54.8623749301
128PhosphorylationVHACIGGTSFVEDAE
EEEEECCCCHHHCCC		17.4928889911
129PhosphorylationHACIGGTSFVEDAEG
EEEECCCCHHHCCCC		30.4828889911
146PhosphorylationDAQIVVGTPGRVFDN
CCEEEECCCCCCCCH		15.8017330950
163AcetylationRRRFRTDKIKMFILD
HHCCCCCCCEEEEEH		43.5425381059
225SuccinylationNPVRILVKKDELTLE
CCEEEEEECCEEEHH		51.5723954790
225AcetylationNPVRILVKKDELTLE
CCEEEEEECCEEEHH		51.5724489116
226SuccinylationPVRILVKKDELTLEG
CEEEEEECCEEEHHH		49.2923954790
226UbiquitinationPVRILVKKDELTLEG
CEEEEEECCEEEHHH		49.2923749301
226AcetylationPVRILVKKDELTLEG
CEEEEEECCEEEHHH		49.2924489116
272UbiquitinationIFCNTRRKVEELTTK
HHCCCHHHHHHHHHH		51.1923749301
279AcetylationKVEELTTKLRNDKFT
HHHHHHHHHHCCCEE		39.9722865919
284AcetylationTTKLRNDKFTVSAIY
HHHHHCCCEEEEEEE		46.6224489116
284UbiquitinationTTKLRNDKFTVSAIY
HHHHHCCCEEEEEEE		46.6224961812
304AcetylationQERDTIMKEFRSGSS
HHHHHHHHHHHCCCC		50.2624489116
304SuccinylationQERDTIMKEFRSGSS
HHHHHHHHHHHCCCC		50.2623954790
304UbiquitinationQERDTIMKEFRSGSS
HHHHHHHHHHHCCCC		50.2623749301
341AcetylationNYDLPANKENYIHRI
ECCCCCCCCCCCHHC		49.8224489116
357UbiquitinationRGGRFGRKGVAINFV
CCCCCCCCCEEEEEE		59.1023749301
381PhosphorylationELEKFYSTQIEELPS
HHHHHHHHCHHHCCH		23.3721440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IF4A_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of IF4A_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IF4A_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
IF4F1_YEASTTIF4631physical
11805826
YJK7_YEASTYJL107Cphysical
11805837
IF4F2_YEASTTIF4632physical
11805837
IF4F1_YEASTTIF4631physical
11805837
IF4E_YEASTCDC33physical
11805837
IF4F1_YEASTTIF4631physical
10409745
IF4F2_YEASTTIF4632physical
10409745
H2A2_YEASTHTA2physical
16554755
SSH1_YEASTSSH1physical
16554755
DHH1_YEASTDHH1physical
16554755
FAL1_YEASTFAL1physical
16554755
FIMB_YEASTSAC6physical
16554755
SEC5_YEASTSEC5physical
16554755
YD239_YEASTYDR239Cphysical
16554755
HSP7E_YEASTECM10physical
16554755
ARB1_YEASTARB1physical
16554755
IMB4_YEASTKAP123physical
16554755
BUD9_YEASTBUD9physical
16554755
PESC_YEASTNOP7physical
16554755
HIR3_YEASTHIR3physical
16554755
IZH3_YEASTIZH3physical
16554755
EF3A_YEASTYEF3physical
16554755
CSR1_YEASTCSR1physical
16554755
CORO_YEASTCRN1physical
16554755
ADH3_YEASTADH3physical
16554755
UPF3_YEASTUPF3genetic
19061648
NAM7_YEASTNAM7genetic
19061648
NMD2_YEASTNMD2genetic
19061648
IF2A_YEASTSUI2genetic
19061648
IF2M_YEASTIFM1genetic
19061648
AEP3_YEASTAEP3genetic
19061648
IF4F1_YEASTTIF4631physical
18606994
SIR2_YEASTSIR2genetic
21902802
STE50_YEASTSTE50genetic
27708008
GPR1_YEASTGPR1genetic
27708008
GPG1_YEASTGPG1genetic
27708008
AROC_YEASTARO2genetic
27708008
YG1A_YEASTYGR016Wgenetic
27708008
RL26B_YEASTRPL26Bgenetic
27708008
FHN1_YEASTFHN1genetic
27708008
VPS62_YEASTVPS62genetic
27708008
SS100_YEASTSPS100genetic
27708008
PRY2_YEASTPRY2genetic
27708008
PAU23_YEASTPAU23genetic
27708008
RL22A_YEASTRPL22Agenetic
27708008
ATG33_YEASTATG33genetic
27708008
CDC73_YEASTCDC73genetic
27708008
RL9B_YEASTRPL9Bgenetic
27708008
CISY1_YEASTCIT1genetic
27708008
RAD1_YEASTRAD1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
CDC24_YEASTCDC24genetic
27708008
KPC1_YEASTPKC1genetic
27708008
EIF3A_YEASTRPG1genetic
27708008
DBF4_YEASTDBF4genetic
27708008
ERF3_YEASTSUP35genetic
27708008
GPI11_YEASTGPI11genetic
27708008
GPI8_YEASTGPI8genetic
27708008
MOB2_YEASTMOB2genetic
27708008
STT3_YEASTSTT3genetic
27708008
COPB2_YEASTSEC27genetic
27708008
GPI10_YEASTGPI10genetic
27708008
YHS2_YEASTCIA2genetic
27708008
GPI16_YEASTGPI16genetic
27708008
FDFT_YEASTERG9genetic
27708008
ARPC5_YEASTARC15genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SEC13_YEASTSEC13genetic
27708008
CD123_YEASTCDC123genetic
27708008
SEC22_YEASTSEC22genetic
27708008
TAD3_YEASTTAD3genetic
27708008
DCP2_YEASTDCP2genetic
27708008
DED1_YEASTDED1genetic
27708008
MYO2_YEASTMYO2genetic
27708008
EIF3B_YEASTPRT1genetic
27708008
YBQ6_YEASTYBR056Wgenetic
27708008
SGF29_YEASTSGF29genetic
27708008
CSM1_YEASTCSM1genetic
27708008
NHP10_YEASTNHP10genetic
27708008
RAD57_YEASTRAD57genetic
27708008
DOS2_YEASTDOS2genetic
27708008
MNN10_YEASTMNN10genetic
27708008
VHR2_YEASTVHR2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
RT31_YEASTYMR31genetic
27708008
YG036_YEASTYGL036Wgenetic
27708008
PEX14_YEASTPEX14genetic
27708008
AIM14_YEASTAIM14genetic
27708008
MTO1_YEASTMTO1genetic
27708008
YG2W_YEASTYGR111Wgenetic
27708008
NMD2_YEASTNMD2genetic
27708008
ADY1_YEASTPFS1genetic
27708008
YIF4_YEASTYIL054Wgenetic
27708008
VPS24_YEASTVPS24genetic
27708008
NNK1_YEASTNNK1genetic
27708008
YRA2_YEASTYRA2genetic
27708008
PYRD_YEASTURA1genetic
27708008
MMM1_YEASTMMM1genetic
27708008
PSR1_YEASTPSR1genetic
27708008
YL040_YEASTAFB1genetic
27708008
PDC1_YEASTPDC1genetic
27708008
RS30A_YEASTRPS30Agenetic
27708008
RS30B_YEASTRPS30Agenetic
27708008
ROM2_YEASTROM2genetic
27708008
TSR2_YEASTTSR2genetic
27708008
YMD7_YEASTYML037Cgenetic
27708008
GSF2_YEASTGSF2genetic
27708008
MSC1_YEASTMSC1genetic
27708008
NAM7_YEASTNAM7genetic
27708008
YMX7_YEASTYMR087Wgenetic
27708008
ATG16_YEASTATG16genetic
27708008
ERG2_YEASTERG2genetic
27708008
UBP8_YEASTUBP8genetic
27708008
FAR11_YEASTFAR11genetic
27708008
RTC5_YEASTRTC5genetic
27708008
SLK19_YEASTSLK19genetic
27708008
LCF1_YEASTFAA1genetic
27708008
MTHR1_YEASTMET12genetic
27708008
SGF11_YEASTSGF11genetic
27708008
AIM44_YEASTAIM44genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IF4A_YEAST

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Proteome studies of Saccharomyces cerevisiae: identification andcharacterization of abundant proteins.";
Garrels J.I., McLaughlin C.S., Warner J.R., Futcher B., Latter G.I.,Kobayashi R., Schwender B., Volpe T., Anderson D.S.,Mesquita-Fuentes R., Payne W.E.;
Electrophoresis 18:1347-1360(1997).
Cited for: ACETYLATION AT SER-2.
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-128; SER-129 ANDTHR-146, AND MASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-146, AND MASSSPECTROMETRY.

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