| UniProt ID | EIF3A_YEAST | |
|---|---|---|
| UniProt AC | P38249 | |
| Protein Name | Eukaryotic translation initiation factor 3 subunit A {ECO:0000255|HAMAP-Rule:MF_03000} | |
| Gene Name | RPG1 {ECO:0000255|HAMAP-Rule:MF_03000} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 964 | |
| Subcellular Localization | Cytoplasm . | |
| Protein Description | RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.. | |
| Protein Sequence | MAPPPFRPENAIKRADELISVGEKQAALQSLHDFITARRIRWATPSTVEPVVFKFLEIGVELKKGKLLKDGLHQYKKLIQGSTEGLVSVGAVARKFIDLVESKIASEQTRADELQKQEIDDDLEGGVTPENLLISVYESDQSVAGFNDEAITSWLRFTWESYRAVLDLLRNNALLEITYSGVVKKTMHFCLKYQRKNEFKRLAEMLRQHLDAANYQQSKSGNNLVDLSDADTLQRYLDQRFQQVDVSVKLELWHEAYRSIEDVFHLMKISKRAPKPSTLANYYENLVKVFFVSGDPLLHTTAWKKFYKLYSTNPRATEEEFKTYSSTIFLSAISTQLDEIPSIGYDPHLRMYRLLNLDAKPTRKEMLQSIIEDESIYGKVDEELKELYDIIEVNFDVDTVKQQLENLLVKLSSKTYFSQYIAPLRDVIMRRVFVAASQKFTTVSQSELYKLATLPAPLDLSAWDIEKSLLQAAVEDYVSITIDHESAKVTFAKDPFDIFASTASKEVSEEENTEPEVQEEKEETDEALGPQETEDGEEKEEESDPVIIRNSYIHNKLLELSNVLHDVDSFNNASYMEKVRIARETLIKKNKDDLEKISKIVDERVKRSQEQKQKHMEHAALHAEQDAEVRQQRILEEKAAIEAKLEEEAHRRLIEKKKREFEAIKEREITKMITEVNAKGHVYIDPNEAKSLDLDTIKQVIIAEVSKNKSELESRMEYAMKKLDHTERALRKVELPLLQKEVDKLQETDTANYEAMKKKIVDAAKAEYEARMADRKNLVMVYDDYLKFKEHVSGTKESELAAIRNQKKAELEAAKKARIEEVRKRRYEEAIARRKEEIANAERQKRAQELAEATRKQREIEEAAAKKSTPYSFRAGNREPPSTPSTLPKATVSPDKAKLDMIAQKQREMEEAIEQRLAGRTAGGSSPATPATPATPATPTPSSGPKKMTMAEKLRAKRLAKGGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 24 | Ubiquitination | ELISVGEKQAALQSL HHHHHHHHHHHHHHH | 39.03 | 17644757 | |
| 69 | Acetylation | LKKGKLLKDGLHQYK EECCCCCCCCHHHHH | 61.25 | 24489116 | |
| 76 | Ubiquitination | KDGLHQYKKLIQGST CCCHHHHHHHHCCCC | 34.24 | 17644757 | |
| 77 | Ubiquitination | DGLHQYKKLIQGSTE CCHHHHHHHHCCCCC | 45.98 | 17644757 | |
| 95 | Acetylation | SVGAVARKFIDLVES HHHHHHHHHHHHHHH | 36.61 | 24489116 | |
| 95 | Ubiquitination | SVGAVARKFIDLVES HHHHHHHHHHHHHHH | 36.61 | 17644757 | |
| 192 | Acetylation | KTMHFCLKYQRKNEF HHHHHHHHHHCHHHH | 40.28 | 24489116 | |
| 192 | Methylation | KTMHFCLKYQRKNEF HHHHHHHHHHCHHHH | 40.28 | 20137074 | |
| 220 | Phosphorylation | ANYQQSKSGNNLVDL HHHCCCCCCCCCCCC | 52.58 | 23749301 | |
| 268 | Ubiquitination | EDVFHLMKISKRAPK HHHHHHHHHHHCCCC | 50.63 | 24961812 | |
| 268 | Acetylation | EDVFHLMKISKRAPK HHHHHHHHHHHCCCC | 50.63 | 24489116 | |
| 271 | Acetylation | FHLMKISKRAPKPST HHHHHHHHCCCCCCH | 56.93 | 25381059 | |
| 275 | Acetylation | KISKRAPKPSTLANY HHHHCCCCCCHHHHH | 51.09 | 24489116 | |
| 277 | Phosphorylation | SKRAPKPSTLANYYE HHCCCCCCHHHHHHH | 42.02 | 22369663 | |
| 278 | Phosphorylation | KRAPKPSTLANYYEN HCCCCCCHHHHHHHH | 38.12 | 22369663 | |
| 282 | Phosphorylation | KPSTLANYYENLVKV CCCHHHHHHHHHHHH | 13.42 | 22369663 | |
| 283 | Phosphorylation | PSTLANYYENLVKVF CCHHHHHHHHHHHHE | 9.73 | 22369663 | |
| 288 | Ubiquitination | NYYENLVKVFFVSGD HHHHHHHHHEEECCC | 36.17 | 17644757 | |
| 304 | Acetylation | LLHTTAWKKFYKLYS CCCHHHHHHHHHHHC | 30.46 | 24489116 | |
| 304 | Ubiquitination | LLHTTAWKKFYKLYS CCCHHHHHHHHHHHC | 30.46 | 17644757 | |
| 305 | Ubiquitination | LHTTAWKKFYKLYST CCHHHHHHHHHHHCC | 43.13 | 17644757 | |
| 308 | Acetylation | TAWKKFYKLYSTNPR HHHHHHHHHHCCCCC | 44.04 | 24489116 | |
| 360 | Ubiquitination | RLLNLDAKPTRKEML HHHCCCCCCCHHHHH | 46.73 | 23749301 | |
| 360 | Acetylation | RLLNLDAKPTRKEML HHHCCCCCCCHHHHH | 46.73 | 24489116 | |
| 410 | Acetylation | QLENLLVKLSSKTYF HHHHHHHHHHCCCHH | 42.49 | 24489116 | |
| 493 | Acetylation | SAKVTFAKDPFDIFA CCEEEEECCHHHHHH | 62.84 | 24489116 | |
| 501 | Phosphorylation | DPFDIFASTASKEVS CHHHHHHCCCCCCCC | 17.47 | 28889911 | |
| 502 | Phosphorylation | PFDIFASTASKEVSE HHHHHHCCCCCCCCC | 31.36 | 25521595 | |
| 504 | Phosphorylation | DIFASTASKEVSEEE HHHHCCCCCCCCCCC | 29.45 | 25521595 | |
| 508 | Phosphorylation | STASKEVSEEENTEP CCCCCCCCCCCCCCH | 40.14 | 22369663 | |
| 513 | Phosphorylation | EVSEEENTEPEVQEE CCCCCCCCCHHHHHH | 57.08 | 25521595 | |
| 524 | Phosphorylation | VQEEKEETDEALGPQ HHHHHHHHCHHHCCC | 39.98 | 22369663 | |
| 533 | Phosphorylation | EALGPQETEDGEEKE HHHCCCCCCCCCCCC | 33.84 | 22369663 | |
| 543 | Phosphorylation | GEEKEEESDPVIIRN CCCCCCCCCCEEEEC | 50.96 | 28889911 | |
| 589 | Acetylation | ARETLIKKNKDDLEK HHHHHHHHCHHHHHH | 63.34 | 24489116 | |
| 599 | Acetylation | DDLEKISKIVDERVK HHHHHHHHHHHHHHH | 50.66 | 22865919 | |
| 638 | Acetylation | QQRILEEKAAIEAKL HHHHHHHHHHHHHHH | 33.47 | 24489116 | |
| 644 | Acetylation | EKAAIEAKLEEEAHR HHHHHHHHHHHHHHH | 43.57 | 24489116 | |
| 671 | Acetylation | IKEREITKMITEVNA HHHHHHHHHHHEECC | 33.69 | 24489116 | |
| 690 | Acetylation | YIDPNEAKSLDLDTI EECHHHCCCCCHHHH | 45.43 | 24489116 | |
| 691 | Phosphorylation | IDPNEAKSLDLDTIK ECHHHCCCCCHHHHH | 33.88 | 17330950 | |
| 696 | Phosphorylation | AKSLDLDTIKQVIIA CCCCCHHHHHHHHHH | 37.05 | 19779198 | |
| 698 | Ubiquitination | SLDLDTIKQVIIAEV CCCHHHHHHHHHHHH | 40.37 | 24961812 | |
| 710 | Phosphorylation | AEVSKNKSELESRME HHHHCCHHHHHHHHH | 57.73 | 30377154 | |
| 744 | Acetylation | LLQKEVDKLQETDTA HHHHHHHHHHHCCCC | 58.19 | 24489116 | |
| 748 | Phosphorylation | EVDKLQETDTANYEA HHHHHHHCCCCCHHH | 26.20 | 21126336 | |
| 753 | Phosphorylation | QETDTANYEAMKKKI HHCCCCCHHHHHHHH | 11.55 | 27214570 | |
| 757 | Succinylation | TANYEAMKKKIVDAA CCCHHHHHHHHHHHH | 58.94 | 23954790 | |
| 757 | Acetylation | TANYEAMKKKIVDAA CCCHHHHHHHHHHHH | 58.94 | 24489116 | |
| 759 | 2-Hydroxyisobutyrylation | NYEAMKKKIVDAAKA CHHHHHHHHHHHHHH | 42.30 | - | |
| 765 | Acetylation | KKIVDAAKAEYEARM HHHHHHHHHHHHHHH | 43.39 | 24489116 | |
| 776 | Acetylation | EARMADRKNLVMVYD HHHHCCCCCEEEEEC | 56.00 | 25381059 | |
| 782 | Phosphorylation | RKNLVMVYDDYLKFK CCCEEEEECHHHHHH | 5.75 | 28889911 | |
| 796 | Acetylation | KEHVSGTKESELAAI HHHCCCCCHHHHHHH | 63.87 | 24489116 | |
| 854 | Phosphorylation | AQELAEATRKQREIE HHHHHHHHHHHHHHH | 29.88 | 29688323 | |
| 866 | Acetylation | EIEEAAAKKSTPYSF HHHHHHHHCCCCCCC | 42.40 | 25381059 | |
| 869 | Phosphorylation | EAAAKKSTPYSFRAG HHHHHCCCCCCCCCC | 34.82 | 23749301 | |
| 872 | Phosphorylation | AKKSTPYSFRAGNRE HHCCCCCCCCCCCCC | 14.95 | 24961812 | |
| 882 | Phosphorylation | AGNREPPSTPSTLPK CCCCCCCCCCCCCCC | 64.76 | 29136822 | |
| 883 | Phosphorylation | GNREPPSTPSTLPKA CCCCCCCCCCCCCCC | 27.34 | 29136822 | |
| 885 | Phosphorylation | REPPSTPSTLPKATV CCCCCCCCCCCCCCC | 42.54 | 29136822 | |
| 886 | Phosphorylation | EPPSTPSTLPKATVS CCCCCCCCCCCCCCC | 48.56 | 24961812 | |
| 889 | Ubiquitination | STPSTLPKATVSPDK CCCCCCCCCCCCCCH | 60.86 | 17644757 | |
| 893 | Phosphorylation | TLPKATVSPDKAKLD CCCCCCCCCCHHHHH | 24.03 | 25521595 | |
| 898 | Acetylation | TVSPDKAKLDMIAQK CCCCCHHHHHHHHHH | 51.24 | 24489116 | |
| 921 | Phosphorylation | EQRLAGRTAGGSSPA HHHHCCCCCCCCCCC | 28.83 | 22369663 | |
| 925 | Phosphorylation | AGRTAGGSSPATPAT CCCCCCCCCCCCCCC | 32.03 | 22369663 | |
| 926 | Phosphorylation | GRTAGGSSPATPATP CCCCCCCCCCCCCCC | 23.10 | 22369663 | |
| 929 | Phosphorylation | AGGSSPATPATPATP CCCCCCCCCCCCCCC | 19.48 | 22369663 | |
| 932 | Phosphorylation | SSPATPATPATPATP CCCCCCCCCCCCCCC | 18.05 | 22369663 | |
| 935 | Phosphorylation | ATPATPATPATPTPS CCCCCCCCCCCCCCC | 18.05 | 17330950 | |
| 938 | Phosphorylation | ATPATPATPTPSSGP CCCCCCCCCCCCCCC | 28.97 | 17330950 | |
| 940 | Phosphorylation | PATPATPTPSSGPKK CCCCCCCCCCCCCCC | 31.29 | 28889911 | |
| 942 | Phosphorylation | TPATPTPSSGPKKMT CCCCCCCCCCCCCCC | 50.86 | 30377154 | |
| 943 | Phosphorylation | PATPTPSSGPKKMTM CCCCCCCCCCCCCCH | 61.39 | 21440633 | |
| 946 | Ubiquitination | PTPSSGPKKMTMAEK CCCCCCCCCCCHHHH | 59.72 | 17644757 | |
| 947 | Ubiquitination | TPSSGPKKMTMAEKL CCCCCCCCCCHHHHH | 42.61 | 17644757 | |
| 953 | Acetylation | KKMTMAEKLRAKRLA CCCCHHHHHHHHHHH | 33.46 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EIF3A_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EIF3A_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EIF3A_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220; SER-508; SER-893AND SER-926, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-893 AND SER-926, ANDMASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-691 AND THR-935, ANDMASS SPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-926, AND MASSSPECTROMETRY. | |
