CSN11_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN11_YEAST
• UniProt AC: P40512
• Protein Name: Cop9 signalosome complex subunit 11
• Gene Name: PCI8
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 444
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control..
• Protein Sequence: MFHGAKGPLLIERIGHLLSINYGEKEERKRWAMQGISYLQEVQCTSTPYLEILVEESGLRPVSLLNSQLVGKPHFSLLGGFDENIARDIISHNFQNAIFQMESEEVPLTKRYQHLEKITQISLLCKNFKGIEEIEYNVKNIIQGRKNFDMLNSMEKDRISHEVVQDDSFSLLRIQMLLCVSYFLQERYFDCCTKFFTMMTSEPLTLKVLSEHLDCMNFISKEEFIMMVNISVLISIPLDNYDDFIYLSDLKQFFQMTPLLVNCLELLINTNFNKFFKIWHGEINKICMESLFLEPSWSSSAAVIMRCKIYFFYLRISKKLQFSYLSSTLGIDLEDIKEELTKLIISGQLNFEIDGDVIHFEDSSILQSIVNEISRNGTMINEVIDKLKNENTDLKDIIQGNPLMYSGGNNTATIINNESSDDMDIDEVNDRSDISDSEGGLFEC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
103	Phosphorylation	NAIFQMESEEVPLTK HHHHHCCCCCCCCCH	33.44	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN11_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN11_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN11_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3B_YEAST	PRT1	physical	11457827
IF2A_YEAST	SUI2	physical	11457827
RPN5_YEAST	RPN5	physical	16554755
CSN5_YEAST	RRI1	physical	16554755
CSN9_YEAST	CSN9	physical	16554755
SKP1_YEAST	SKP1	physical	16554755
CSI1_YEAST	CSI1	physical	16554755
SSB2_YEAST	SSB2	physical	16554755
CSI1_YEAST	CSI1	physical	16429126
CSN9_YEAST	CSN9	physical	16429126
RPN5_YEAST	RPN5	physical	16429126
CSN5_YEAST	RRI1	physical	16429126
CSN10_YEAST	RRI2	physical	16429126
BUD31_YEAST	BUD31	genetic	20093466
NHP10_YEAST	NHP10	genetic	20093466
MED5_YEAST	NUT1	genetic	20093466
IME2_YEAST	IME2	genetic	20093466
ENV10_YEAST	ENV10	genetic	20093466
SWI6_YEAST	SWI6	genetic	20093466
CDA2_YEAST	CDA2	genetic	20093466
SEI1_YEAST	FLD1	genetic	20093466
ASND1_YEAST	YML096W	genetic	20093466
TSA1_YEAST	TSA1	genetic	20093466
YMB8_YEAST	YML018C	genetic	20093466
NDH1_YEAST	NDE1	genetic	20093466
BCH1_YEAST	BCH1	genetic	20093466
YM94_YEAST	YMR315W	genetic	20093466
YNE0_YEAST	YNL040W	genetic	20093466
AGA1_YEAST	AGA1	genetic	20093466
TRM11_YEAST	TRM11	genetic	20093466
WHI5_YEAST	WHI5	genetic	20093466
TMA46_YEAST	TMA46	genetic	20093466
SUCA_YEAST	LSC1	genetic	20093466
IES4_YEAST	IES4	genetic	20093466
MDL2_YEAST	MDL2	genetic	20093466
KES1_YEAST	KES1	physical	22940862
NHP10_YEAST	NHP10	genetic	27708008
GPR1_YEAST	GPR1	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
IME2_YEAST	IME2	genetic	27708008
SWI6_YEAST	SWI6	genetic	27708008
CDA2_YEAST	CDA2	genetic	27708008
BUD8_YEAST	BUD8	genetic	27708008
SEI1_YEAST	FLD1	genetic	27708008
TDA5_YEAST	TDA5	genetic	27708008
GIS4_YEAST	GIS4	genetic	27708008
MSC1_YEAST	MSC1	genetic	27708008
MAC1_YEAST	MAC1	genetic	27708008
SPO1_YEAST	SPO1	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
WHI5_YEAST	WHI5	genetic	27708008
TMA46_YEAST	TMA46	genetic	27708008
YORA4_YEAST	YOR114W	genetic	27708008
FYV12_YEAST	FYV12	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.