CSN10_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN10_YEAST
• UniProt AC: Q12348
• Protein Name: COP9 signalosome complex subunit 10
• Gene Name: RRI2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 645
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response..
• Protein Sequence: MSDEDNNYDDFMLSDDEGMESIEMEEETDDEDKQNIEINEDNSQDDQDRGAARHKQHEQGTFEKHDRVEDICERIFEQGQALKEDERYKEARDLFLKIYYKEEFSSDESIERLMTWKFKSLIEILRLRALQLYFQKNGAQDLVLQILEDTATMSVFLQRIDFQIDGNIFELLSDTFEVLAPKWERVFLFDIEKVDRENMICKIDFQKNFMDQFQWILRKPGKDCKLQNLQRIIRKKIFIAVVWYQRLTMGNVFTPEISSQIEILVKDNECSSFEENNDLESVSMLLQYYILEYMNTARINNRRLFKKCIDFFEMLISKSLTFSQESGLMVILYTSKIVFILDSDSENDLSFALMRYYDRKEELKNMFLYILKHLEEMGKLRERDITSLFHKFILSGFIFTSMILEAISTDKINPFGFEQVKIALGSPIVNVLEDVYRCFAQLELRQLNASISLIPELSVVLSGIIQDIYYLAQTLKLWRKIARLYSCISISDIISMLQISDDNEMTRDDLLTILMRSIMKNRSVVYFKLDLTSDLVYFGDENKVMLPRCSKEEFRLMISPKDEETTEKARLIDFEYVNDVAIYNNPTRIRTKSSKEFFNTLRKSRETVKLPRVSNQSNEDTFLPSYMKFSNKYLELCKLASNNLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	IEINEDNSQDDQDRG CCCCCCCCCCCHHHH	47.51	28889911
150	Phosphorylation	VLQILEDTATMSVFL HHHHHHHHHHHHHHH	18.04	27017623
152	Phosphorylation	QILEDTATMSVFLQR HHHHHHHHHHHHHHH	16.45	27017623
154	Phosphorylation	LEDTATMSVFLQRID HHHHHHHHHHHHHCE	12.83	28889911
565	Phosphorylation	ISPKDEETTEKARLI ECCCCHHHCHHEEEC	37.90	27214570
566	Phosphorylation	SPKDEETTEKARLID CCCCHHHCHHEEECC	38.48	27214570

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN10_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN10_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN10_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN12_YEAST	YJR084W	physical	12672462
CSN12_YEAST	YJR084W	physical	12446563
RPN5_YEAST	RPN5	physical	16554755
CSN5_YEAST	RRI1	physical	16554755
SYSC_YEAST	SES1	physical	16554755
SKP1_YEAST	SKP1	physical	16554755
FCP1_YEAST	FCP1	physical	16554755
EIF3J_YEAST	HCR1	genetic	19061648
CSK2B_YEAST	CKB1	genetic	19061648
NCBP1_YEAST	STO1	genetic	19061648
IMB4_YEAST	KAP123	genetic	19061648
CSN10_YEAST	RRI2	physical	21289098
CSN5_YEAST	RRI1	physical	21289098
CSN11_YEAST	PCI8	physical	21289098
CSI1_YEAST	CSI1	physical	21289098
CSN9_YEAST	CSN9	physical	21289098
RPN5_YEAST	RPN5	physical	21289098
RPN6_YEAST	RPN6	physical	21289098
PRS7_YEAST	RPT1	physical	21289098
RPN2_YEAST	RPN2	physical	21289098
PRS6B_YEAST	RPT3	physical	21289098
PSD10_YEAST	NAS6	physical	21289098
UBI4P_YEAST	UBI4	physical	21289098
UBP3_YEAST	UBP3	physical	21289098
BRE5_YEAST	BRE5	physical	21289098
BRE1_YEAST	BRE1	physical	21289098
HSE1_YEAST	HSE1	physical	21289098
SAN1_YEAST	SAN1	physical	21289098
CUE2_YEAST	CUE2	physical	21289098
EIF2A_YEAST	YGR054W	physical	21289098
CLU_YEAST	CLU1	physical	21289098
EIF3A_YEAST	RPG1	physical	21289098
EIF3B_YEAST	PRT1	physical	21289098
IF4E_YEAST	CDC33	physical	21289098
IF5A1_YEAST	HYP2	physical	21289098
PNG1_YEAST	PNG1	physical	21289098
OLA1_YEAST	OLA1	physical	21289098
CD123_YEAST	CDC123	physical	21289098
PABP_YEAST	PAB1	physical	21289098
SAC3_YEAST	SAC3	genetic	29674565
NBP2_YEAST	NBP2	genetic	29674565
CAP_YEAST	SRV2	genetic	29674565

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.