CUE2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUE2_YEAST
• UniProt AC: P36075
• Protein Name: Ubiquitin-binding protein CUE2
• Gene Name: CUE2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 443
• Protein Sequence: MSMDNNDDHESKLSILMDMFPAISKSKLQVHLLENNNDLDLTIGLLLKENDDKSTVDNELHQLYDMFPQLDCSVIKDQFVINEKSVESTISDLLNYETLQKLKDNQANSPDSVKRNEKKNNWESTNDHIESIIKFTDAPKNIAQEYLAENGFDTVKAIIKIILDYYDKRDFKKDVDTFKVKRSPNTTVRGGRVQSSTGLAHVLKKGKESANVAQESLKRPRSYKHSLDSPQMVELNELVADNRDLKAINHEFLQKCLQFYDGDVVKVLNISSLLIEDDKNITKTWNFDEGFTLTSRDNCKQHLPKFSTPQISRRNEVGNTYKLPLHDKETPEGAVPVINNLFQTYRLDFHGFLPSEAVSTLKLALNKWWSKEVAERELNSHNINSYGSKVQFVSPLIVVTGRGIHSIGGISKVRLQVKSFLEKNHYIFWEESSYFRIEGKKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	DNNDDHESKLSILMD CCCCCHHHHHHHHHH	35.16	28132839
14	Phosphorylation	DDHESKLSILMDMFP CCHHHHHHHHHHHHH	19.88	30377154
26	Phosphorylation	MFPAISKSKLQVHLL HHHHHCHHHHEEEEE	31.63	30377154
109	Phosphorylation	LKDNQANSPDSVKRN HHHCCCCCCHHHHHH	32.85	17563356
112	Phosphorylation	NQANSPDSVKRNEKK CCCCCCHHHHHHHHC	32.68	17563356
146	Phosphorylation	PKNIAQEYLAENGFD CHHHHHHHHHHCCHH	10.11	30377154
154	Phosphorylation	LAENGFDTVKAIIKI HHHCCHHHHHHHHHH	22.96	30377154
183	Phosphorylation	DTFKVKRSPNTTVRG CCEEEECCCCCEEEC	19.45	28889911
186	Phosphorylation	KVKRSPNTTVRGGRV EEECCCCCEEECCEE	30.01	27017623
187	Phosphorylation	VKRSPNTTVRGGRVQ EECCCCCEEECCEEE	18.17	27017623
195	Phosphorylation	VRGGRVQSSTGLAHV EECCEEECCCHHHHH	27.32	28889911
197	Phosphorylation	GGRVQSSTGLAHVLK CCEEECCCHHHHHHH	41.27	28889911
218	Acetylation	NVAQESLKRPRSYKH HHHHHHHCCCCCCCC	70.41	25381059
411	Phosphorylation	IHSIGGISKVRLQVK CHHCCCHHHEEEEHH	28.51	15665377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CUE2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUE2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUE2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBF1_YEAST	TBF1	physical	10688190
THG1_YEAST	THG1	physical	10688190
UBI4P_YEAST	UBI4	physical	12787503
UBI4P_YEAST	UBI4	physical	25042851

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-112, ANDMASS SPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109 AND SER-112, ANDMASS SPECTROMETRY.
PubMed: 17563356

"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411, AND MASSSPECTROMETRY.
PubMed: 15665377