THG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THG1_YEAST
• UniProt AC: P53215
• Protein Name: tRNA(His) guanylyltransferase
• Gene Name: THG1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 237
• Protein Description: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage..
• Protein Sequence: MANSKFGYVRQFETHDVILPQCYIVVRIDGKKFHEFSKFYEFAKPNDENALKLMNACAKNLVLKYKNDIILAFGESDEYSFILKSSTTLFNRRKDKLATLFGSFFTSNYVALWAKFFPEKPLNIKHLPYFDSRCVAYPNLQTIKDYLSWRYVDTHINNLYNTTFWQLIIKCGLTPQESEKKLCGTFSNEKQEILFSECGINYNNEPEMFKKGSLVTRKGEILHINVIAQIDELFEGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MANSKFGYV ------CCCCCCCCE	29.07	22814378
5	Acetylation	---MANSKFGYVRQF ---CCCCCCCCEEEE	42.49	24489116
125	Acetylation	PEKPLNIKHLPYFDS CCCCCCCCCCCCCCC	37.71	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THG1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THG1_YEAST	THG1	physical	10688190
ORC2_YEAST	ORC2	physical	15821142
YHR2_YEAST	YHR112C	physical	18719252
THG1_YEAST	THG1	physical	18719252
MRC1_YEAST	MRC1	genetic	20093466
YC16_YEAST	YCR087C-A	genetic	20093466
DLD2_YEAST	DLD2	genetic	20093466
GCST_YEAST	GCV1	genetic	20093466
VPS41_YEAST	VPS41	genetic	20093466
BMH2_YEAST	BMH2	genetic	20093466
TMA64_YEAST	TMA64	genetic	20093466
NBP2_YEAST	NBP2	genetic	20093466
SUR2_YEAST	SUR2	genetic	20093466
SNX41_YEAST	SNX41	genetic	20093466
LCMT1_YEAST	PPM1	genetic	20093466
ALR2_YEAST	ALR2	genetic	20093466
FET5_YEAST	FET5	genetic	20093466
WWM1_YEAST	WWM1	genetic	20093466
VID30_YEAST	VID30	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
SODM_YEAST	SOD2	genetic	20093466
AAP1_YEAST	AAP1	genetic	20093466
6P21_YEAST	PFK26	genetic	20093466
YJR1_YEAST	YJL171C	genetic	20093466
YJE9_YEAST	YJL049W	genetic	20093466
DPOD3_YEAST	POL32	genetic	20093466
YJ24_YEAST	KCH1	genetic	20093466
MNS1_YEAST	MNS1	genetic	20093466
PHD1_YEAST	PHD1	genetic	20093466
GAP1_YEAST	GAP1	genetic	20093466
SWI6_YEAST	SWI6	genetic	20093466
NKP2_YEAST	NKP2	genetic	20093466
F16P_YEAST	FBP1	genetic	20093466
YPT7_YEAST	YPT7	genetic	20093466
CSM3_YEAST	CSM3	genetic	20093466
GBLP_YEAST	ASC1	genetic	20093466
GID8_YEAST	GID8	genetic	20093466
VPS27_YEAST	VPS27	genetic	20093466
ATG3_YEAST	ATG3	genetic	20093466
TRM11_YEAST	TRM11	genetic	20093466
VPS17_YEAST	VPS17	genetic	20093466
AIM44_YEAST	AIM44	genetic	20093466
YP096_YEAST	YPR096C	genetic	20093466
SYH_YEAST	HTS1	genetic	20360392
MCM1_YEAST	MCM1	genetic	27708008
PMA2_YEAST	PMA2	genetic	27708008
PRP9_YEAST	PRP9	genetic	27708008
FAD1_YEAST	FAD1	genetic	27708008
COG3_YEAST	COG3	genetic	27708008
BRL1_YEAST	BRL1	genetic	27708008
SMC4_YEAST	SMC4	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
ULP1_YEAST	ULP1	genetic	27708008
NIP7_YEAST	NIP7	genetic	27708008
DIM1_YEAST	DIM1	genetic	27708008
PMP1_YEAST	PMP1	genetic	27708008
PHO87_YEAST	PHO87	genetic	27708008
CSM1_YEAST	CSM1	genetic	27708008
IPT1_YEAST	IPT1	genetic	27708008
MRT4_YEAST	MRT4	genetic	27708008
SWI6_YEAST	SWI6	genetic	27708008
ATG26_YEAST	ATG26	genetic	27708008
ZRC1_YEAST	ZRC1	genetic	27708008
DCAM_YEAST	SPE2	genetic	27708008
BUB3_YEAST	BUB3	genetic	27708008
YME1_YEAST	YME1	genetic	27708008
THG1_YEAST	THG1	physical	28623126

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.