| UniProt ID | YME1_YEAST | |
|---|---|---|
| UniProt AC | P32795 | |
| Protein Name | Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1 | |
| Gene Name | YME1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 747 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Matrix side . Although this protein does not have any predicted transmembrane helices it behaves like an integral membrane protein. |
|
| Protein Description | Catalytic subunit of the mitochondrial inner membrane i-AAA protease supercomplex required for mitochondrial inner membrane protein turnover. The protease is probably ATP-dependent. Important to maintain the integrity of the mitochondrial compartment. Required both for the degradation of unassembled subunit 2 of cytochrome c oxidase (COX2) and for efficient assembly of mitochondrial respiratory chain. Binds unfolded substrates in an ATPase-independent manner; binding of folded COX2, a physiological substrate, requires an active ATPase but when COX2 is destabilized an active ATPase is no longer necessary.. | |
| Protein Sequence | MNVSKILVSPTVTTNVLRIFAPRLPQIGASLLVQKKWALRSKKFYRFYSEKNSGEMPPKKEADSSGKASNKSTISSIDNSQPPPPSNTNDKTKQANVAVSHAMLATREQEANKDLTSPDAQAAFYKLLLQSNYPQYVVSRFETPGIASSPECMELYMEALQRIGRHSEADAVRQNLLTASSAGAVNPSLASSSSNQSGYHGNFPSMYSPLYGSRKEPLHVVVSESTFTVVSRWVKWLLVFGILTYSFSEGFKYITENTTLLKSSEVADKSVDVAKTNVKFDDVCGCDEARAELEEIVDFLKDPTKYESLGGKLPKGVLLTGPPGTGKTLLARATAGEAGVDFFFMSGSEFDEVYVGVGAKRIRDLFAQARSRAPAIIFIDELDAIGGKRNPKDQAYAKQTLNQLLVELDGFSQTSGIIIIGATNFPEALDKALTRPGRFDKVVNVDLPDVRGRADILKHHMKKITLADNVDPTIIARGTPGLSGAELANLVNQAAVYACQKNAVSVDMSHFEWAKDKILMGAERKTMVLTDAARKATAFHEAGHAIMAKYTNGATPLYKATILPRGRALGITFQLPEMDKVDITKRECQARLDVCMGGKIAEELIYGKDNTTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLSENWESWSNKIRDIADNEVIELLKDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLKTSTNTVVEGPDSDERKDIGDDKPKIPTMLNA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 45 | Phosphorylation | ALRSKKFYRFYSEKN HHHCCCCHHHHCCCC | 14.53 | 19779198 | |
| 49 | Phosphorylation | KKFYRFYSEKNSGEM CCCHHHHCCCCCCCC | 39.11 | 19779198 | |
| 53 | Phosphorylation | RFYSEKNSGEMPPKK HHHCCCCCCCCCCCC | 47.39 | 19779198 | |
| 91 | Acetylation | PPSNTNDKTKQANVA CCCCCCHHHHHHHHH | 60.74 | 24489116 | |
| 126 | Ubiquitination | DAQAAFYKLLLQSNY HHHHHHHHHHHHCCC | 26.63 | 17644757 | |
| 304 | Phosphorylation | VDFLKDPTKYESLGG HHHHHCCHHHHHCCC | 57.29 | 28889911 | |
| 308 | Phosphorylation | KDPTKYESLGGKLPK HCCHHHHHCCCCCCC | 29.26 | 28889911 | |
| 315 | Ubiquitination | SLGGKLPKGVLLTGP HCCCCCCCCEEEECC | 72.58 | 17644757 | |
| 327 | Ubiquitination | TGPPGTGKTLLARAT ECCCCCCHHHHHHHH | 35.52 | 22817900 | |
| 388 | Ubiquitination | ELDAIGGKRNPKDQA CHHHCCCCCCHHHHH | 43.73 | 17644757 | |
| 441 | Ubiquitination | TRPGRFDKVVNVDLP HCCCCCCEEECCCCC | 45.42 | 17644757 | |
| 462 | Ubiquitination | DILKHHMKKITLADN HHHHHHHHHCEECCC | 36.35 | 17644757 | |
| 463 | Ubiquitination | ILKHHMKKITLADNV HHHHHHHHCEECCCC | 33.09 | 17644757 | |
| 517 | Acetylation | HFEWAKDKILMGAER HHHHHHHHHHCCCCH | 36.71 | 22865919 | |
| 608 | Ubiquitination | AEELIYGKDNTTSGC HHHHHHCCCCCCCCC | 30.73 | 17644757 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of YME1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of YME1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of YME1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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