| UniProt ID | SEY1_YEAST | |
|---|---|---|
| UniProt AC | Q99287 | |
| Protein Name | Protein SEY1 {ECO:0000255|HAMAP-Rule:MF_03109} | |
| Gene Name | SEY1 {ECO:0000255|HAMAP-Rule:MF_03109} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 776 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . Enriched in the cortical ER. Concentrated in punctae along the ER tubules. |
|
| Protein Description | Cooperates with the reticulon proteins RTN1 and RTN2 and the tubule-shaping DP1 family protein YOP1 to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.. | |
| Protein Sequence | MADRPAIQLIDEEKEFHQSALQYFQQCIGNRDVGLDYHVISVFGSQSSGKSTLLNVLFNTNFDTMDAQVKRQQTTKGIWLAHTKQVNTTIEIDNDRPDIFVLDVEGSDGSERGEDQDFERKAALFAIAVSEVLIVNMWEQQIGLYQGNNMALLKTVFEVNLSLFGKNDNDHKVLLLFVIRDHVGVTPLSSLSDSVTRELEKIWTELSKPAGCEGSSLYDYFDLKFVGLAHKLLQEDKFTQDVKKLGDSFVMKGTENYYFKPQYHHRLPLDGWTMYAENCWDQIERNKDLDLPTQQILVARFKTEEISNEALEEFISKYDESIAPLKGNLGSLTSQLVKLKEECLTKYDEQASRYARNVYMEKREALNTKLNSHISGTINEFLESLMEKLWDDLKLEVSSRDKATTSFVESVAAGKSKIEKEFNESMETFKKLGLLISNEEITCKFSDDIEERIKQLRDAELKAKIGRIKKNLVPELKDHVIHLLSHPSKKVWDDIMNDFESTIKDNISAYQVEKDKYDFKIGLSESENAKIYKNIRILAWRTLDTTVHDYLKIDTIVSILRDRFEDVFRYDAEGSPRLWKTEEEIDGAFRVAKEHALEVFEVLSLAVTSDNVEIIPDVPMAEEESGEDNEIYRDNEGVFHSRRFAHILTELQKENVLDQFRRQINITVLDSKRSIITTRTHIPPWIYVLLAVLGWNEFVAVIRNPLFVTLTLILGATFFVIHKFGLWGPVVNVVQSAVGETRTAIKDKLRQFVVEDHEVKESFEMKDFSKNEQKEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 207 | Phosphorylation | EKIWTELSKPAGCEG HHHHHHHCCCCCCCC | 30.29 | 27017623 | |
| 218 | Phosphorylation | GCEGSSLYDYFDLKF CCCCCCHHHHHHHHH | 15.56 | 27017623 | |
| 220 | Phosphorylation | EGSSLYDYFDLKFVG CCCCHHHHHHHHHHH | 5.85 | 27017623 | |
| 231 | Acetylation | KFVGLAHKLLQEDKF HHHHHHHHHHHHCCC | 45.33 | 24489116 | |
| 237 | Acetylation | HKLLQEDKFTQDVKK HHHHHHCCCHHHHHH | 49.94 | 24489116 | |
| 260 | Acetylation | GTENYYFKPQYHHRL CCCCEEECCCCCCCC | 18.32 | 24489116 | |
| 287 | Acetylation | WDQIERNKDLDLPTQ HHHHHHCCCCCCCHH | 66.93 | 24489116 | |
| 331 | Phosphorylation | PLKGNLGSLTSQLVK CCCCCHHHHHHHHHH | 31.47 | 19795423 | |
| 333 | Phosphorylation | KGNLGSLTSQLVKLK CCCHHHHHHHHHHHH | 19.00 | 19823750 | |
| 334 | Phosphorylation | GNLGSLTSQLVKLKE CCHHHHHHHHHHHHH | 27.15 | 19823750 | |
| 485 | Phosphorylation | DHVIHLLSHPSKKVW HHHHHHHHCCCHHHH | 39.45 | 22369663 | |
| 488 | Phosphorylation | IHLLSHPSKKVWDDI HHHHHCCCHHHHHHH | 39.42 | 22369663 | |
| 514 | Ubiquitination | ISAYQVEKDKYDFKI CCEEEECCCCCCEEE | 61.74 | 24961812 | |
| 530 | Acetylation | LSESENAKIYKNIRI CCHHHCCHHHHCCEE | 59.14 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SEY1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SEY1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SEY1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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