DSL1_YEAST - dbPTM
DSL1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DSL1_YEAST
UniProt AC P53847
Protein Name Protein transport protein DSL1
Gene Name DSL1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 754
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein .
Protein Description Required for protein transport between the Golgi and the endoplasmic reticulum. May tether coatomer-coated retrograde transport vesicles to the ER membrane through interaction with coatomer as well as the SNARE complex. May contribute to the stabilization of the SNARE complex..
Protein Sequence MESLFPNKGEIIRELLKDPLILKNDSKRSNGSELELDSSDLLQREAILANELNILDNLKTFLNLIKEVKTNLNILELENCYYSLQSLRKKMRNNAAYLKQSFNFQQSISTYVDTLHLELVSTLYKILTNGFWKITENSIQFTPTVEWGKDKVHIEYDTFMDFVAQQYFPKGSLDNQAWFILDMTSADSQEQVRAKLNTIMKEYMNLSRIVSMIKNSIFISGKEISYENEKNILVFSKSSSHGQHCVSTVLTSFEAVCDFMLDGLAFRDRKTLSYELGPLFNTEFTKFVKNNASIILESLDSPLKNLVSVINNKLTRLVAKSEVTNWTHSGKEIQDLLMNKQLYYNLLLDKVLESHISEIRSIFEDPKKSWQNLEVVELTTSNTNTMSEKIGKNDSDVQNEKELHNAVSKDDDWNWEVEDDDADAWGDEIDVNIDDEEEKTNQEKEKEPEEEENAWDEAWAIDENIDDASLENGKEHLKAHDVGSLDKDHIEVTQLPKLFLAISQNFKSSFADSHVDEQYFAYKYNLLQTSYMAMCTANFSHNWCQLYVDMRYLIERDEKLYRIKELTRNLLETKLNMKYRIVCQLIRHQLTEFRENERNPSWDATIEKLLPYILKEIVRPLQKIRGEEGSRYLLSFLNFLYNDCVTKEILKWQIISEVNSENLGELVSLLVNNTDIQLLAKEPSYKKMREKFATMGKFLPLHLKEIMEMFYNGDFYLFATDELIQWIELLFADTPLRRNAIDDIYEIRGTALDD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
29PhosphorylationLKNDSKRSNGSELEL
ECCCCCCCCCCCCCC		49.6427214570
32PhosphorylationDSKRSNGSELELDSS
CCCCCCCCCCCCCHH		43.1722369663
38PhosphorylationGSELELDSSDLLQRE
CCCCCCCHHHHHHHH		38.0722369663
39PhosphorylationSELELDSSDLLQREA
CCCCCCHHHHHHHHH		31.7622369663
66AcetylationKTFLNLIKEVKTNLN
HHHHHHHHHHHHCCC		60.6724489116
201AcetylationAKLNTIMKEYMNLSR
HHHHHHHHHHCCHHH		41.6725381059
203PhosphorylationLNTIMKEYMNLSRIV
HHHHHHHHCCHHHHH		5.9329136822
207PhosphorylationMKEYMNLSRIVSMIK
HHHHCCHHHHHHHHH		18.2429136822
392UbiquitinationTMSEKIGKNDSDVQN
HHHHHCCCCHHHHCC		62.1423749301
395PhosphorylationEKIGKNDSDVQNEKE
HHCCCCHHHHCCHHH		49.4228152593
408PhosphorylationKELHNAVSKDDDWNW
HHHHHHCCCCCCCCE		28.1429734811
469PhosphorylationDENIDDASLENGKEH
CCCCCHHHHHCHHHH		43.1221440633
484PhosphorylationLKAHDVGSLDKDHIE
HHHHCCCCCCCCCEE		32.9928889911
612PhosphorylationTIEKLLPYILKEIVR
HHHHHHHHHHHHHHH		20.8925533186
615AcetylationKLLPYILKEIVRPLQ
HHHHHHHHHHHHHHH		35.5224489116
623AcetylationEIVRPLQKIRGEEGS
HHHHHHHHHCCCHHH		41.8924489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DSL1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DSL1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DSL1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TIP20_YEASTTIP20physical
11283351
COPD_YEASTRET2physical
11739780
COPD_YEASTRET2physical
14504276
TIP20_YEASTTIP20physical
14504276
COPA_YEASTCOP1physical
14504276
SEC39_YEASTSEC39physical
15958492
USE1_YEASTUSE1physical
15958492
SEC20_YEASTSEC20physical
15958492
TIP20_YEASTTIP20physical
15958492
UFE1_YEASTUFE1physical
15958492
ERV14_YEASTERV14genetic
11260526
COPG_YEASTSEC21genetic
11260526
SLY1_YEASTSLY1genetic
11260526
BOS1_YEASTBOS1genetic
11493604
SEC20_YEASTSEC20genetic
11739780
TIP20_YEASTTIP20genetic
11739780
SEC20_YEASTSEC20genetic
11493604
COPG_YEASTSEC21genetic
11493604
SEC22_YEASTSEC22genetic
11493604
SLY1_YEASTSLY1genetic
11493604
TIP20_YEASTTIP20genetic
11493604
COPA_YEASTCOP1genetic
11493604
SEC39_YEASTSEC39genetic
15958492
SEC39_YEASTSEC39physical
16429126
TIP20_YEASTTIP20physical
16429126
USE1_YEASTUSE1physical
16429126
RIC1_YEASTRIC1genetic
16269340
ATC3_YEASTDRS2genetic
16269340
TRS85_YEASTTRS85genetic
16269340
CHO2_YEASTCHO2genetic
16269340
MKAR_YEASTIFA38genetic
16269340
IRE1_YEASTIRE1genetic
16269340
NTR2_YEASTNTR2physical
11283351
SEC39_YEASTSEC39physical
11283351
COPA_YEASTCOP1physical
19758564
COPA_YEASTCOP1genetic
19758564
TIP20_YEASTTIP20physical
21482823
SEC39_YEASTSEC39physical
21550981
TIP20_YEASTTIP20physical
21550981
SEC20_YEASTSEC20physical
21550981
UFE1_YEASTUFE1physical
21550981
USE1_YEASTUSE1physical
21550981
YKT6_YEASTYKT6physical
21550981
ACT_YEASTACT1genetic
25187651
PYC2_YEASTPYC2genetic
25187651
ATG15_YEASTATG15genetic
25187651
BRE5_YEASTBRE5genetic
25187651
UFE1_YEASTUFE1genetic
25187651
USE1_YEASTUSE1genetic
25187651
RSC9_YEASTRSC9genetic
25187651
COPZ_YEASTRET3genetic
25187651
SEY1_YEASTSEY1genetic
25187651
SWC5_YEASTSWC5genetic
25187651
RT103_YEASTRTT103genetic
25187651
SEC22_YEASTSEC22genetic
25187651
TF3B_YEASTBRF1genetic
25187651
SEN1_YEASTSEN1genetic
25187651
ASK10_YEASTASK10genetic
25187651
UBP3_YEASTUBP3genetic
25187651
COPA_YEASTCOP1genetic
25187651
COPB_YEASTSEC26genetic
25187651
ICE2_YEASTICE2genetic
25187651
INO4_YEASTINO4genetic
25187651
TAF10_YEASTTAF10genetic
25187651
CY1_YEASTCYT1genetic
25187651
MPCP_YEASTMIR1genetic
25187651
ESL2_YEASTESL2genetic
25187651
YJ24_YEASTKCH1genetic
25187651
DBP5_YEASTDBP5genetic
25187651
ESA1_YEASTESA1genetic
25187651
IMB3_YEASTPSE1genetic
25187651
HIR1_YEASTHIR1genetic
25187651
MPS3_YEASTMPS3genetic
25187651
CHK1_YEASTCHK1genetic
25187651
MED9_YEASTCSE2genetic
25187651
BBP1_YEASTBBP1genetic
25187651
FIP1_YEASTFIP1genetic
25187651
STU2_YEASTSTU2genetic
25187651
MED19_YEASTROX3genetic
25187651
CND1_YEASTYCS4genetic
25187651
GPI13_YEASTGPI13genetic
25187651
FBRL_YEASTNOP1genetic
25187651
YP022_YEASTYPR022Cgenetic
25187651
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DSL1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND MASSSPECTROMETRY.

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