dbPTM

MKAR_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MKAR_YEAST
UniProt AC	P38286
Protein Name	Very-long-chain 3-oxoacyl-CoA reductase {ECO:0000255\|HAMAP-Rule:MF_03107}
Gene Name	IFA38
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	347
Subcellular Localization	Endoplasmic reticulum membrane Single-pass membrane protein .
Protein Description	Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids..
Protein Sequence	MTFMQQLQEAGERFRCINGLLWVVFGLGVLKCTTLSLRFLALIFDLFLLPAVNFDKYGAKTGKYCAITGASDGIGKEFARQMAKRGFNLVLISRTQSKLEALQKELEDQHHVVVKILAIDIAEDKESNYESIKELCAQLPITVLVNNVGQSHSIPVPFLETEEKELRNIITINNTATLLITQIIAPKIVETVKAENKKSGTRGLILTMGSFGGLIPTPLLATYSGSKSFLQGWSNSLAGELSKDAIDVELIISYLVTSSMSKIRRSSLMIPNPQQFVKSTLRSVGRRCGSQERYATMTPYWAHAVYQFVITETFGVYSKIVNSINYSFHKSIRIRALKKAARQVKKE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Ubiquitination	NFDKYGAKTGKYCAI CHHHCCCCCCCEEEE	54.14	22817900
63	Ubiquitination	KYGAKTGKYCAITGA HCCCCCCCEEEECCC	42.25	23749301
63	Acetylation	KYGAKTGKYCAITGA HCCCCCCCEEEECCC	42.25	24489116
76	Ubiquitination	GASDGIGKEFARQMA CCCCCCHHHHHHHHH	47.97	23749301
76	Acetylation	GASDGIGKEFARQMA CCCCCCHHHHHHHHH	47.97	24489116
97	Phosphorylation	VLISRTQSKLEALQK EEEECCHHHHHHHHH	38.30	28889911
98	Acetylation	LISRTQSKLEALQKE EEECCHHHHHHHHHH	40.29	24489116
177	Phosphorylation	ITINNTATLLITQII EEECCHHHHHHHHHH	21.76	27017623
181	Phosphorylation	NTATLLITQIIAPKI CHHHHHHHHHHHHHH	17.43	27017623
278	Acetylation	PNPQQFVKSTLRSVG CCHHHHHHHHHHHHH	38.72	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MKAR_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MKAR_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MKAR_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELO2_YEAST	ELO2	genetic	12087109
PMT2_YEAST	PMT2	physical	16554755
YEL1_YEAST	YEL1	physical	16554755
HMO1_YEAST	HMO1	physical	16554755
YRA1_YEAST	YRA1	physical	16554755
PMA1_YEAST	PMA1	physical	16554755
SLM1_YEAST	SLM1	physical	16554755
MTC1_YEAST	MTC1	physical	16554755
ARP3_YEAST	ARP3	physical	16554755
COFI_YEAST	COF1	physical	16554755
CDC3_YEAST	CDC3	physical	16554755
CORO_YEAST	CRN1	physical	16554755
VDAC1_YEAST	POR1	physical	16554755
ARPC2_YEAST	ARC35	physical	16554755
KIN4_YEAST	KIN4	physical	16554755
LCB2_YEAST	LCB2	genetic	16269340
GET2_YEAST	GET2	genetic	16269340
JEM1_YEAST	JEM1	genetic	16269340
SSO2_YEAST	SSO2	genetic	16269340
AGP1_YEAST	AGP1	genetic	16269340
LHS1_YEAST	LHS1	genetic	16269340
DSL1_YEAST	DSL1	genetic	16269340
DPM1_YEAST	DPM1	genetic	16269340
BFR1_YEAST	BFR1	genetic	16269340
COPE_YEAST	SEC28	genetic	16269340
HSP71_YEAST	SSA1	physical	19536198
AYR1_YEAST	AYR1	genetic	12087109
ELO3_YEAST	ELO3	genetic	12087109
TECR_YEAST	TSC13	genetic	12087109
EI2BB_YEAST	GCD7	physical	23263984
EI2BG_YEAST	GCD1	physical	23263984
EI2BD_YEAST	GCD2	physical	23263984
EI2BA_YEAST	GCN3	physical	23263984
EI2BE_YEAST	GCD6	physical	23263984

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MKAR_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-97, AND MASSSPECTROMETRY.	18407956 [Abstract]