| UniProt ID | EI2BD_YEAST | |
|---|---|---|
| UniProt AC | P12754 | |
| Protein Name | Translation initiation factor eIF-2B subunit delta | |
| Gene Name | GCD2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 651 | |
| Subcellular Localization | ||
| Protein Description | Acts as essential component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD2 is also required for cell viability. Its function can partially be replaced by GCN3 under normal growth conditions in GCD2-defective mutants, under AA starvation conditions GCN3 is an antagonist (GCN4 translational activator).. | |
| Protein Sequence | MSESEAKSRSATPPSKAKQATPTTTAAANGEKKLTNKELKELKKQEKAAKRAAMKQANGISIEQQQQQAQMKKEKKQLQREQQQKREQKQKNANKKKQNERNVKKSTLFGHLETTEERRATILALTSAVSSPKTSRITAAGLMVPVVASALSGSNVLTASSLMPVGPNASSTVSASAPASTTTTLPASSAALSAGTSSASTNTPTAIQQEIASSNASDVAKTLASISLEAGEFNVIPGISSVIPTVLEQSFDNSSLISSVKELLLNKDLIHPSILLLTSHLAHYKIVGSIPRCIAMLEVFQIVIKDYQTPKGTTLSRNLTSYLSHQIDLLKKARPLSVTMGNAIRWLKQEISLIDPSTPDKAAKKDLCEKIGQFAKEKIELADQLIIDNASTQIEESTTIVTYGSSKVLTELLLHNAISLKKNIKVIVVDSRPLFEGRKMAETLRNAGVNVMYALITSLDTIFNMDVDYVFLGAHSILSNGFLYSRAGTAMLAMSAKRRNIPVLVCCESLKFSQRVQLDSVTFNELADPNDLVNIDYENPVERRGNKGALLNQFIKERKFEKKKLAMENKPKGNKIGGKKGSEGESKDASNEEDSNSKNILDGWQELPSLNIVNILYDLTPPEYIKKVITEFGALPPSSVPVILREYKGSA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSESEAKSR ------CCHHHHHHC | 50.24 | 22814378 | |
| 2 | Phosphorylation | ------MSESEAKSR ------CCHHHHHHC | 50.24 | 30377154 | |
| 4 | Phosphorylation | ----MSESEAKSRSA ----CCHHHHHHCCC | 35.23 | 30377154 | |
| 8 | Phosphorylation | MSESEAKSRSATPPS CCHHHHHHCCCCCCH | 38.22 | 19823750 | |
| 10 | Phosphorylation | ESEAKSRSATPPSKA HHHHHHCCCCCCHHC | 43.52 | 19823750 | |
| 12 | Phosphorylation | EAKSRSATPPSKAKQ HHHHCCCCCCHHCCC | 36.66 | 25752575 | |
| 15 | Phosphorylation | SRSATPPSKAKQATP HCCCCCCHHCCCCCC | 46.58 | 19823750 | |
| 18 | Ubiquitination | ATPPSKAKQATPTTT CCCCHHCCCCCCCCH | 44.17 | 23749301 | |
| 21 | Phosphorylation | PSKAKQATPTTTAAA CHHCCCCCCCCHHHH | 20.76 | 22369663 | |
| 23 | Phosphorylation | KAKQATPTTTAAANG HCCCCCCCCHHHHCC | 32.21 | 22369663 | |
| 24 | Phosphorylation | AKQATPTTTAAANGE CCCCCCCCHHHHCCC | 18.68 | 22369663 | |
| 25 | Phosphorylation | KQATPTTTAAANGEK CCCCCCCHHHHCCCC | 19.44 | 22369663 | |
| 55 | Ubiquitination | AAKRAAMKQANGISI HHHHHHHHHHHCCCH | 41.34 | 23749301 | |
| 106 | Phosphorylation | NERNVKKSTLFGHLE HHHHHHHHHHHHCCC | 25.32 | - | |
| 121 | Phosphorylation | TTEERRATILALTSA CCHHHHHHHHHHHHH | 18.08 | - | |
| 126 | Phosphorylation | RATILALTSAVSSPK HHHHHHHHHHCCCCC | 14.72 | 29688323 | |
| 127 | Phosphorylation | ATILALTSAVSSPKT HHHHHHHHHCCCCCC | 27.76 | 29688323 | |
| 130 | Phosphorylation | LALTSAVSSPKTSRI HHHHHHCCCCCCCCC | 40.41 | 28132839 | |
| 131 | Phosphorylation | ALTSAVSSPKTSRIT HHHHHCCCCCCCCCC | 24.66 | 25752575 | |
| 135 | Phosphorylation | AVSSPKTSRITAAGL HCCCCCCCCCCHHHC | 28.01 | 28889911 | |
| 273 | Phosphorylation | NKDLIHPSILLLTSH CCCCCCHHHHHHHHH | 16.23 | 22369663 | |
| 278 | Phosphorylation | HPSILLLTSHLAHYK CHHHHHHHHHHHHHH | 17.67 | 22369663 | |
| 279 | Phosphorylation | PSILLLTSHLAHYKI HHHHHHHHHHHHHHH | 19.24 | 22369663 | |
| 284 | Phosphorylation | LTSHLAHYKIVGSIP HHHHHHHHHHHCCHH | 9.23 | 22369663 | |
| 311 | Ubiquitination | IKDYQTPKGTTLSRN HHCCCCCCCCCCCHH | 72.74 | 23749301 | |
| 331 | Acetylation | SHQIDLLKKARPLSV HHHHHHHHHCCCCCH | 52.24 | 24489116 | |
| 348 | Acetylation | GNAIRWLKQEISLID HHHHHHHHHHHCCCC | 38.64 | 24489116 | |
| 361 | Acetylation | IDPSTPDKAAKKDLC CCCCCCCHHHHHHHH | 51.99 | 24489116 | |
| 370 | Ubiquitination | AKKDLCEKIGQFAKE HHHHHHHHHHHHHHH | 51.66 | 23749301 | |
| 556 | Acetylation | ALLNQFIKERKFEKK HHHHHHHHHHHHHHH | 53.40 | 24489116 | |
| 627 | Ubiquitination | TPPEYIKKVITEFGA CCHHHHHHHHHHHCC | 29.34 | 24961812 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EI2BD_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EI2BD_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EI2BD_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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